2-Bromopyridine
- Product Name
- 2-Bromopyridine
- CAS No.
- 109-04-6
- Chemical Name
- 2-Bromopyridine
- Synonyms
- -Bromopyridine;-Bromoazine;2-Brompyridin;2-Bromopyridine;2-bromo-pyridin;o-Bromopyridine;2-pyridylbromide;AKOS BBS-00004324;BROMOPYRIDINE(2-);Pyridine,2-bromo-
- CBNumber
- CB3465833
- Molecular Formula
- C5H4BrN
- Formula Weight
- 158
- MOL File
- 109-04-6.mol
2-Bromopyridine Property
- Melting point:
- 193°C
- Boiling point:
- 192-194 °C (lit.)
- Density
- 1.657 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.572(lit.)
- Flash point:
- 130 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 20g/l
- form
- Liquid
- pka
- pK1: 0.71(+1) (25°C)
- color
- Clear colorless to pale brown
- Water Solubility
- Slightly miscible with water.
- BRN
- 105789
- Dielectric constant
- 24.02
- Stability:
- Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides.
- InChIKey
- IMRWILPUOVGIMU-UHFFFAOYSA-N
- LogP
- 1.42
- CAS DataBase Reference
- 109-04-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridine, 2-bromo-(109-04-6)
- EPA Substance Registry System
- Pyridine, 2-bromo- (109-04-6)
Safety
- Hazard Codes
- T,Xn,F
- Risk Statements
- 10-24/25-36/37/38-23/24/25-20/21/22
- Safety Statements
- 16-36/37-45-38-36/37/39-28A-26
- RIDADR
- UN 2929 6.1/PG 2
- WGK Germany
- 3
- RTECS
- US3850000
- F
- 8
- Hazard Note
- Toxic
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H310Fatal in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P262Do not get in eyes, on skin, or on clothing.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B80100
- Product name
- 2-Bromopyridine
- Purity
- 99%
- Packaging
- 25g
- Price
- $43.1
- Updated
- 2024/03/01
- Product number
- B80100
- Product name
- 2-Bromopyridine
- Purity
- 99%
- Packaging
- 100g
- Price
- $123
- Updated
- 2024/03/01
- Product number
- B0650
- Product name
- 2-Bromopyridine
- Purity
- >98.0%(GC)
- Packaging
- 25mL
- Price
- $53
- Updated
- 2024/03/01
- Product number
- B0650
- Product name
- 2-Bromopyridine
- Purity
- >98.0%(GC)
- Packaging
- 100mL
- Price
- $146
- Updated
- 2024/03/01
- Product number
- A13241
- Product name
- 2-Bromopyridine, 99%
- Packaging
- 25g
- Price
- $41
- Updated
- 2024/03/01
2-Bromopyridine Chemical Properties,Usage,Production
Chemical Properties
light yellow oily or dark red liquid. miscible with ethanol, ether, benzene and pyridine, still soluble in water.
Uses
2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.
Application
2-Bromopyridine can be used as:
A building block in the formation of C?N bond by various cross coupling reactions.
A reactant in Negishi cross-coupling reaction with aryl halides catalyzed by palladium.
A reactant in the synthesis of 2′-pyridyldifluoroacetate with ethyl bromodifluoroacetate in presence of copper as a catalyst.
Preparation
2-Bromopyridine is synthesized from 2-aminopyridine by bromination. In industrial production, hydrobromic acid (over 48%) is first cooled to below 0°C, 2-aminopyridine is slowly added, and then liquid bromine is added dropwise in a salt bath under freezing, and the rate of addition is to control the reaction temperature below -5°C appropriate. After adding, add sodium nitrite aqueous solution dropwise, control the reaction temperature to be below 0°C, stir for 20-30min, dropwise add 50% sodium hydroxide solution, extract the reaction solution with ether, wash with water, dry with anhydrous sodium sulfate, filter, and recover Diethyl ether, the residue was distilled under reduced pressure, and the 88°C-94°C/3333Pa fraction was collected to obtain the finished product of 2-bromopyridine with a yield of 83.8%.
Definition
ChEBI: 2-bromopyridine is a monobromopyridine.
Reactions
2-Bromopyridine reacts with butyllithium to give 2-lithiopyridine, which is a versatile reagent.Pyrithione can be prepared in a two-step synthesis from 2-bromopyridine by oxidation to the N-oxide with a suitable peracid followed by substitution using either sodium dithionite or sodium sulfide with sodium hydroxide to introduce the thiol functional group.
Flammability and Explosibility
Flammable
Purification Methods
Dry 2-bromopyridine over KOH for several days, then distil it from CaO under reduced pressure, and taking the middle fraction. [Beilstein 20/5 V 422.]
2-Bromopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromopyridine manufacturers
- Product
- 2-Bromopyridine 109-04-6
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10ton/month
- Release date
- 2021-05-28
- Product
- 2-Bromopyridine 109-04-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 10 ton
- Release date
- 2024-08-21
- Product
- 2-Bromopyridine 109-04-6
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99.96%
- Supply Ability
- 500ton
- Release date
- 2023-08-08