2-Bromo-6-methoxypyridine
- Product Name
- 2-Bromo-6-methoxypyridine
- CAS No.
- 40473-07-2
- Chemical Name
- 2-Bromo-6-methoxypyridine
- Synonyms
- NSC 84173;6-BroMo-2-Methoxypyridine;2-BROMO-6-METHOXYPYRIDINE;2-Methoxy-6-broMopyridine;2-BROMO-6-METHOXYPYRIMIDINE;Pyridine, 2-broMo-6-Methoxy-;2-Bromo-6-(methyloxy)pyridine;2-Bromo-6-methoxypyridine >2-BROMO-6-METHOXY-PYRIDINE 98%;2-Bromo-6-methoxypyridine ,98%
- CBNumber
- CB1210598
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 40473-07-2.mol
2-Bromo-6-methoxypyridine Property
- Boiling point:
- 206 °C (lit.)
- Density
- 1.53 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.559(lit.)
- Flash point:
- 220 °F
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -1.04±0.10(Predicted)
- form
- Liquid
- color
- Clear colorless to golden
- InChI
- InChI=1S/C6H6BrNO/c1-9-6-4-2-3-5(7)8-6/h2-4H,1H3
- InChIKey
- KMODISUYWZPVGV-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC(OC)=CC=C1
- CAS DataBase Reference
- 40473-07-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 520535
- Product name
- 2-Bromo-6-methoxypyridine
- Purity
- 97%
- Packaging
- 5ml
- Price
- $75.56
- Updated
- 2025/07/31
- Product number
- B3260
- Product name
- 2-Bromo-6-methoxypyridine
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- B3260
- Product name
- 2-Bromo-6-methoxypyridine
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $120
- Updated
- 2025/07/31
- Product number
- B696875
- Product name
- 2-Bromo-6-methoxypyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 018312
- Product name
- 2-Bromo-6-methoxypyridine
- Purity
- 98+%
- Packaging
- 25g
- Price
- $54
- Updated
- 2021/12/16
2-Bromo-6-methoxypyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow liquid
Uses
The commercial 2-Bromo-6-methoxypyridine could be used as a starting material to synthesize cyclopenta[b]pyridin-2,5-dione. The overall route consists of a first sequence of regioselective ortho lithiation and methoxycarbonylation followed by Heck vinylation, alkene reduction, cyclization, and decarboxylation[1].
Synthesis
626-05-1
124-41-4
40473-07-2
Under argon protection, sodium methanol (1.82 g) was slowly added to a solution of toluene (120 mL) containing 2,6-dibromopyridine (8.0 g), followed by continuous stirring at 120 °C for 13 hours. During the reaction, sodium methanol (0.728 g) was added supplementally and stirring was continued at the same temperature for 6 hours. Upon completion of the reaction, the mixture was naturally cooled to room temperature. The reaction mixture was transferred to a dispensing funnel and partitioned by adding water and ethyl acetate. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the solvent was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford 2-bromo-6-methoxypyridine as an oil (5.64 g, 89% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 3.93 (3H, s, OCH3), 6.68 (1H, d, J = 8.0 Hz, Ar-H), 7.05 (1H, d, J = 7.2 Hz, Ar-H), 7.39-7.42 (1H, m, Ar-H).
References
[1] Robert, Nicolas , et al. "A convenient synthesis of cyclopenta[b]pyridin-2,5-dione as a non- glycosidic cardiotonic agent." ARKIVOC 2008.7(2008):92-100.
2-Bromo-6-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-6-methoxypyridine Suppliers
- Tel
- 0515-82159099 13770142076
- Fax
- 86-0515-8215909
- info@njuchem.com
- Country
- China
- ProdList
- 242
- Advantage
- 65
- Tel
- 86-27-82330560
- Fax
- 86-27-82330547
- 2536851935@qq.com
- Country
- China
- ProdList
- 347
- Advantage
- 69
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
View Lastest Price from 2-Bromo-6-methoxypyridine manufacturers
- Product
- 2-Bromo-6-methoxypyridine 40473-07-2
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-11-28
- Product
- 2-Bromo-6-methoxypyridine 40473-07-2
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 2-Bromo-6-methoxypyridine 40473-07-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-13