2-BROMO-6-METHYLANILINE
- Product Name
- 2-BROMO-6-METHYLANILINE
- CAS No.
- 53848-17-2
- Chemical Name
- 2-BROMO-6-METHYLANILINE
- Synonyms
- 2-broMo-6-MethylbenzenaMine;Dasatinib Impurity O;2-BROMO-6-METHYLANILINE;2-Bromo-6-methylaniline 95%;2-Bromo-6-methyl-phenylamine;2-BroMo-6-Methylaniline, 95+%;Benzenamine, 2-bromo-6-methyl-;2-BROMO-6-METHYLANILINE ISO 9001：2015 REACH
- CBNumber
- CB2390295
- Molecular Formula
- C7H8BrN
- Formula Weight
- 186.05
- MOL File
- 53848-17-2.mol
2-BROMO-6-METHYLANILINE Property
- Boiling point:
- 105-107 °C/205 mmHg (lit.)
- Density
- 1.4780 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.6030(lit.)
- Flash point:
- 215 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 2.39±0.10(Predicted)
- Appearance
- Off-white to yellow Solid-Liquid Mixture
- InChI
- InChI=1S/C7H8BrN/c1-5-3-2-4-6(8)7(5)9/h2-4H,9H2,1H3
- InChIKey
- LDUCMSVRKKDATH-UHFFFAOYSA-N
- SMILES
- C1(N)=C(C)C=CC=C1Br
- CAS DataBase Reference
- 53848-17-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 563048
- Product name
- 2-Bromo-6-methylaniline
- Purity
- 95%
- Packaging
- 1g
- Price
- $146
- Updated
- 2023/06/20
- Product number
- 563048
- Product name
- 2-Bromo-6-methylaniline
- Purity
- 95%
- Packaging
- 5g
- Price
- $271
- Updated
- 2023/06/20
- Product number
- 3730-9-09
- Product name
- 2-Bromo-6-methylaniline
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB140702
- Product name
- 2-Bromo-6-methylaniline
- Packaging
- 5G
- Price
- $61
- Updated
- 2021/12/16
- Product number
- 074812
- Product name
- 2-Bromo-6-methylaniline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $89
- Updated
- 2021/12/16
2-BROMO-6-METHYLANILINE Chemical Properties,Usage,Production
Uses
2-Bromo-6-methylaniline can be used as a reactant to synthesize:
- Alkyl substituted bromoindazole building blocks by Pd-catalyzed Suzuki coupling reaction with various vinyl boronic acids.
- Difluoropyridoindole via Pd-catalyzed intramolecular Heck reaction with difluoropiperidinone.
- 4-Methyl-N-phenyl-1H-benzo[d]imidazol-2-amine by one-pot Cu-catalyzed domino C-N cross-coupling reaction with iodobenzene and thiourea.
Synthesis
52414-97-8
53848-17-2
The general procedure for the synthesis of 2-bromo-6-methylaniline from 3-bromo-2-nitrotoluene was as follows: tellurium (21.6 g, 169.4 mmol) and sodium borohydride (15.0 g, 396 mmol) were dissolved in 575 mL of anhydrous ethanol under the protection of nitrogen, heated and refluxed for 1 h and then cooled to room temperature. Subsequently, a solution of 3-bromo-2-nitrotoluene (7.32 g, 33.8 mmol) dissolved in 25 mL of ethanol was added all at once and the reaction mixture was stirred for 2 hours at room temperature. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth (CELITE). The filtrate was evaporated under reduced pressure and the residue was dissolved in about 200 mL of ether, washed with saturated brine and dried over anhydrous magnesium sulfate. Finally, the solvent was evaporated to give 2.66 g (42% yield) of 2-bromo-6-methylaniline as a dark liquid.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 11, p. 3177 - 3180
[2] Patent: US2004/110815, 2004, A1. Location in patent: Page/Page column 18
[3] Patent: WO2005/16892, 2005, A1. Location in patent: Page/Page column 68
[4] Chemische Berichte, 1937, vol. 70, p. 2427,2430
[5] Yakugaku Zasshi, 1837, vol. 58, p. 1,7
2-BROMO-6-METHYLANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-6-METHYLANILINE manufacturers
- Product
- 2-BROMO-6-METHYLANILINE 53848-17-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14