2-Trifluoromethyl-6-pyridinecarboxylic acid
- Product Name
- 2-Trifluoromethyl-6-pyridinecarboxylic acid
- CAS No.
- 131747-42-7
- Chemical Name
- 2-Trifluoromethyl-6-pyridinecarboxylic acid
- Synonyms
- 6-(TRIFLUOROMETHYL)PICOLINIC ACID;2-Trifluoromethyl-6-pyridinecarb;2-Trifluoromethyl-6-pyridinecarboxylic;2-Trifluoromethyl-6-pyridinecarboxylic aci;6-TRIFLUOROMETHYLPYRIDINE-2-CARBOXYLIC ACID;2-TRIFLUOROMETHYL-6-PYRIDINECARBOXYLIC ACID;6-TrifluoroMethyl-2-pyridinecarboxylic acid;2-Carboxylic acid-6-trifluoromethylpyridine;6-(trifluoroMethyl)pyridin-2-carboxylic acid;2-（Trifluoromethyl）pyridine-6-carboxylic acid
- CBNumber
- CB9252727
- Molecular Formula
- C7H4F3NO2
- Formula Weight
- 191.11
- MOL File
- 131747-42-7.mol
2-Trifluoromethyl-6-pyridinecarboxylic acid Property
- Melting point:
- 154-158 °C
- Boiling point:
- 263.0±40.0 °C(Predicted)
- Density
- 1.484±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- Solid
- pka
- 3.21±0.10(Predicted)
- color
- Off-white
- InChI
- InChI=1S/C7H4F3NO2/c8-7(9,10)5-3-1-2-4(11-5)6(12)13/h1-3H,(H,12,13)
- InChIKey
- OKBHXGBLXDNJJD-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC(C(F)(F)F)=CC=C1
- CAS DataBase Reference
- 131747-42-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- RIDADR
- UN2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HazardClass
- 6.1
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 739804
- Product name
- 6-(Trifluoromethyl)pyridine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $70.7
- Updated
- 2025/07/31
- Product number
- T3270
- Product name
- 6-(Trifluoromethyl)-2-pyridinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $91
- Updated
- 2025/07/31
- Product number
- T896358
- Product name
- 6-(Trifluoromethyl)picolinicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H21-3-Z3
- Product name
- 6-(Trifluoromethyl)pyridine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 5G
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 032538
- Product name
- 6-(Trifluoromethyl)pyridine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $89
- Updated
- 2021/12/16
2-Trifluoromethyl-6-pyridinecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
A useful organic intermediate.
Synthesis
124-38-9
189278-27-1
131747-42-7
General procedure for the synthesis of 6-(trifluoromethyl)pyridine-2-carboxylic acid from carbon dioxide and 2-bromo-6-trifluoromethylpyridine: 1. 2-Bromo-6-(trifluoromethyl)pyridine (100 mg, 0.44 mmol, 1 eq.) was dissolved in anhydrous ether at room temperature and protected by nitrogen and subsequently cooled to -70 °C. 2. 1.6 M hexane solution of n-butyllithium (0.28 mL, 0.44 mmol, 1 eq.) was added slowly and dropwise through the addition funnel. 3. The reaction mixture was stirred at -40 °C for 15 minutes and then cooled to -70 °C again. 4. Carbon dioxide gas was introduced into the reaction mixture and continuously bubbled for 10 minutes. 5. Allow the reaction mixture to warm slowly to room temperature. 6. 6. the reaction was terminated by addition of water and subsequently washed three times with ether. 7. Adjust the pH of the aqueous layer to 3 with concentrated hydrochloric acid. 8. Extracted the acidic aqueous layer with ethyl acetate three times. 9. The ethyl acetate layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 6-(trifluoromethyl)pyridine-2-carboxylic acid (30 mg) as a white solid in 35% yield. 10. The product was detected by LCMS and the molecular ion peak (M + H)+ = 192.06 was confirmed.
References
[1] European Journal of Organic Chemistry, 2003, # 8, p. 1559 - 1568
[2] Patent: US2005/54626, 2005, A1. Location in patent: Page/Page column 36
2-Trifluoromethyl-6-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Trifluoromethyl-6-pyridinecarboxylic acid manufacturers
- Product
- 2-Trifluoromethyl-6-pyridinecarboxylic acid 131747-42-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 6-(Trifluoromethyl)picolinic acid 131747-42-7
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-11
- Product
- 2-Trifluoromethyl-6-pyridinecarboxylic acid 131747-42-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-25