ChemicalBook > CAS DataBase List > Pyridine-2,6-dicarboxylic acid

Pyridine-2,6-dicarboxylic acid

Product Name
Pyridine-2,6-dicarboxylic acid
CAS No.
499-83-2
Chemical Name
Pyridine-2,6-dicarboxylic acid
Synonyms
PYRIDINE-2,6-DICARBOXYLIC ACID;DIPICOLINIC ACID;2,6-DIPICOLINIC ACID;Pyridine-2,6-dicarboxylate;2,6-PYRIDINECARBOXYLIC ACID;26DPA;L-042134;AKOS 2002;dipicolinic;JACS-499-83-2
CBNumber
CB1457234
Molecular Formula
C7H5NO4
Formula Weight
167.12
MOL File
499-83-2.mol
More
Less

Pyridine-2,6-dicarboxylic acid Property

Melting point:
248-250 °C (dec.)(lit.)
Boiling point:
295.67°C (rough estimate)
Density 
1.5216 (rough estimate)
vapor pressure 
<0.01 hPa (20 °C)
refractive index 
1.6280 (estimate)
Flash point:
188 °C
storage temp. 
Store below +30°C.
solubility 
H2O: 1%, clear
pka
2.16(at 25℃)
form 
Crystalline Powder
color 
White
PH
2.0 (5g/l, H2O, 20℃)
Water Solubility 
5 g/L (20 ºC)
BRN 
131629
InChIKey
WJJMNDUMQPNECX-UHFFFAOYSA-N
LogP
0.3 at 25℃ and pH1.8
CAS DataBase Reference
499-83-2(CAS DataBase Reference)
NIST Chemistry Reference
2,6-Pyridinedicarboxylic acid(499-83-2)
EPA Substance Registry System
2,6-Pyridinedicarboxylic acid (499-83-2)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-37/38-36
Safety Statements 
26-36-24/25-37
WGK Germany 
3
Autoignition Temperature
620 °C
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29333999
Toxicity
LD50 orally in Rabbit: 10500 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.00614
Product name
Pyridine-2,6-dicarboxylic acid
Purity
for synthesis
Packaging
100g
Price
$94.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00614
Product name
Pyridine-2,6-dicarboxylic acid
Purity
for synthesis
Packaging
1kg
Price
$429
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00614
Product name
Pyridine-2,6-dicarboxylic acid
Purity
for synthesis
Packaging
25kg
Price
$9050
Updated
2024/03/01
Sigma-Aldrich
Product number
02321
Product name
2,6-Pyridinedicarboxylic acid
Purity
for ion chromatography, ≥99.5% (T)
Packaging
5G
Price
$48.2
Updated
2022/05/15
Sigma-Aldrich
Product number
02321
Product name
2,6-Pyridinedicarboxylic acid
Purity
for ion chromatography, ≥99.5% (T)
Packaging
10g
Price
$79.2
Updated
2022/05/15
More
Less

Pyridine-2,6-dicarboxylic acid Chemical Properties,Usage,Production

Description

2,6-Pyridinedicarboxylic acid (PDCA) contains two carboxylic groups on each side of the pyridine ring. Both groups form rigid 120° angles with the pyridine. Carboxylic functionality could be complex and bind with metals under certain conditions. Numerous metal?organic frameworks, metal complexes, drugs, and CPs based on PDCA were developed for applications related to gas storage, separation, catalysis, magnetism, and sensing[1]. Shao et al. researched the solubility of PDCA in methanol, ethanol, n-propanol, isopropanol, THF, 1,4-dioxane, acetic acid, formic acid, acetonitrile, ethyl acetate, and toluene. They found that PDCA solubility was the highest in methanol but the lowest in acetonitrile.

Chemical Properties

White crystalline powder. Insoluble in ethanol.

Uses

Pyridine-2,6-dicarboxylic acid is used in the preparation of dipicolinato ligated lanthanide and transition metal complexes. It acts as a chelating agent for chromium, zinc, manganese, copper, iron and molybdenum. Its calcium-dipcolinic acid complex is used to protect deoxyribonucleic acid (DNA) from heat denaturation which enhances the DNA stability. It plays an important role as a marker for the effectiveness of sterilization.

Definition

ChEBI: Pyridine-2,6-dicarboxylic acid is a pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6. It has a role as a bacterial metabolite. It is a conjugate acid of a dipicolinate(1-).

Application

2,6-Pyridinedicarboxylic acid is an amphoteric polar metabolite produced by many bacterial and fungal species. Prior to its discovery as a microbial metabolite, dipicolinic acid had long been recognised as a chelating agent for many metal ions. Wide distribution of dipicolinic acid among microbes makes it an important dereplication standard in discovery. Dipicolinic acid reaches high concentrations (~10% w/w) in Bacillus endospores aiding heat resistance and is used in laboratories as a marker for the effectiveness of sterilisation.

Preparation

pyridine-2,6-dicarboxylic acid was synthesized by hydrolyzing of ester prepared by coupling of diethyl 4-hydroxypyridine-2,6-dicarboxylate to bis-halohydrocarbon or bis-halide.
Synthesis of Novel Derivatives of Pyridine‐2,6‐dicarboxylic Acid

Synthesis Reference(s)

Synthetic Communications, 22, p. 2691, 1992 DOI: 10.1080/00397919208021669

General Description

This certified eluent concentrate for ion chromatography is traceable by potentiometric titration to NIST Standard Reference Material. It is certified in accordance with ISO Guide 31. All details about exact content, uncertainty, traceability and expiry date are described in the certificate.

References

[1] Xianzhao Shao. Solubility Thermodynamic Modeling and Solubility Parameter of 2,6- Pyridinedicarboxylic Acid in Selected Solvents at Different Temperatures[J]. J. Chem. Eng. Data, 2021. DOI:org/10.1021/acs.jced.1c00200.

More
Less

Pyridine-2,6-dicarboxylic acid Suppliers

Jinan Dexinjia Bio&Tech Co., Ltd
Tel
0531-82371986 15064117275
Fax
0531-82375893
Email
daisy@jndxj.com
Country
China
ProdList
1321
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Shanghai Witofly Chemical Co. ,Ltd.
Tel
021-5063062 15821189163
Email
sales@witofly.com
Country
China
ProdList
1606
Advantage
55
Changsha Changtang Import and Export Co., LTD
Tel
18942506900
Fax
0731-84372366
Email
492657010@qq.com
Country
China
ProdList
1003
Advantage
58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
869
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5904
Advantage
65
Beijing OKA biological technology co., LTD
Tel
010-010-010-62971590 18548936886
Fax
010-62340519
Email
jack@oka-vip.com
Country
China
ProdList
6897
Advantage
58
Hubei Qifei Pharmaceutical Chemical Co., Ltd
Tel
027-027-59322506 18071128681
Fax
027-59322506
Email
1438082200@qq.com
Country
China
ProdList
9975
Advantage
58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.
Tel
0513-82104991 18912868361
Fax
QQ1907456386
Email
sales11@btcpharm.com
Country
China
ProdList
1333
Advantage
58
Wuhan EnTai Technology Development Co,.Ltd
Tel
86-27-82330560
Fax
86-27-82330547
Email
2536851935@qq.com
Country
China
ProdList
347
Advantage
69
More
Less

View Lastest Price from Pyridine-2,6-dicarboxylic acid manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Pyridine-2,6-dicarboxylic acid 499-83-2
Price
US $100.00-70.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-16
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2,6-Pyridinedicarboxylic acid 499-83-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-18
Asia Chem I and E (Jiangsu) Co Ltd
Product
2,6-Pyridinedicarboxylic acid 499-83-2
Price
US $79.54/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.00%HPLC
Supply Ability
5tons/month
Release date
2021-11-09

499-83-2, Pyridine-2,6-dicarboxylic acidRelated Search:


  • Pyridine-2,6-dicarboxylic acid 98%
  • 2,6-Pyridinedicarboxylic acid solution, Eluent concentrate for IC, 0.02M in water
  • 2,6-PyridinedicarboxylicAcid99%
  • Pyridine-2,6-dicarboxylicacid,98%
  • IFLAB-BB F0451-0137
  • LABOTEST-BB LT00848023
  • RARECHEM AL BO 1335
  • PYRIDINE-2,6-DICARBOXYLIC ACID
  • 2,6-Dicarboxypyridine
  • 2,6-Pyridinedicarboxylic acid-2,6-dipicolinic acid
  • dipicolinic
  • Pyridinedicarboxylic acid-(2,6)
  • JACS-499-83-2
  • 2,6-Pyridinedicarboxylic acid 99%
  • 2,6-Pyridinedicarboxylic Acid(DPA)
  • 2,6-Pyridinedicarboxylic acid concentrate
  • Dipicolinic Acid 〔Pyridine-2,6-dicarboxylic Acid〕
  • Pyridine-2,6-dicarboxylic acid for synthesis
  • 2,6-DIPICOLINIC ACID
  • 2,6-PYRIDINEDICARBOXYLIC ACID
  • AKOS 2002
  • DIPICOLINIC ACID
  • 'DIPICOLINIC ACID'
  • 6-Pyridinedicarboxylic acid
  • 2,6-PyridinedicarboxyL
  • 2,6-PYRIDINECARBOXYLIC ACID
  • DIPLCOLINIC ACID OR PYRIDINE-2,6-DCA PYRIDINE-2,6-DICARBOXYLIC ACID
  • 2,6-PYRIDINEDICARBOXYLIC ACID (DIPICOLINIC ACID)
  • PYRIDINE-2,6-DICARBOXYLIC ACID extrapure
  • 2,6-Pyridinedicarboxylic acid solution
  • Dipicolinic acid solution
  • 6-Carboxypicolinic acid
  • L-042134
  • Pyridine-2,6-biscarboxylic acid
  • Pyridine-2,6-dicarboxylate
  • 2,6-Pyridine Dicarboxylic Acid 98% Min
  • 2,6-Pyridinedicarboxylic acid, 99% 100GR
  • 2,6-Pyridinedicarboxylic acid, 99% 25GR
  • 2,6-Pyridinedicarboxylic acid, 99% 500GR
  • 2,6-Pyridinedicarboxylic acid , Pyridine-2,6-dicarboxylic acid
  • PYRIDINE-2,6-DICARBOXYLIC ACID FOR SYNTH
  • 2,6-Pyridin-dicarboxylic acid
  • Pyridinedicarboxylic aci
  • 2,6-PyridinedicarboxylicAcid&gt
  • ipicolinicaci
  • 2,6-Pyridinedicarboxylic acid ISO 9001:2015 REACH
  • Pyridine-2,6-dimethyl acid
  • 2,6-Pyridinedicarboxylic acida
  • CAS No. 499-83-2
  • Pyridin-2,6-dicarbonsure
  • 2,6-Pyridinedicarboxylic acid/Pyridine-2,6-dicarboxylic acid/Dipicolinic acid/DPA
  • 3-Fluoropropiophenone 455-67-4
  • 2,6-Pyridinedicarboxylic acid (8CI, 9CI, ACI)
  • 2,6-Dipyridinecarboxylic acid
  • 26DPA
  • 499-83-2
  • 207-894-3
  • Analytical Reagents