ChemicalBook > CAS DataBase List > 2-Pyridinecarboxaldehyde

2-Pyridinecarboxaldehyde

Product Name
2-Pyridinecarboxaldehyde
CAS No.
1121-60-4
Chemical Name
2-Pyridinecarboxaldehyde
Synonyms
PICOLINALDEHYDE;PYRIDINE-2-ALDEHYDE;PYRIDINE-2-CARBOXALDEHYDE;PYRIDINE-2-CARBALDEHYDE;2-Pyridinecarboxyaldehyde;2-FORMYLPYRIDINE;2-PYRIDINECARBALDEHYDE;Pyridine-2-formaldehyde;2-PA;Picolinal
CBNumber
CB0153722
Molecular Formula
C6H5NO
Formula Weight
107.11
MOL File
1121-60-4.mol
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2-Pyridinecarboxaldehyde Property

Melting point:
-21--22°C
Boiling point:
181 °C(lit.)
Density 
1.126 g/mL at 25 °C(lit.)
vapor pressure 
73Pa at 20℃
refractive index 
n20/D 1.536(lit.)
Flash point:
130 °F
storage temp. 
2-8°C
form 
liquid (strong colored)
pka
3.8(at 20℃)
color 
Clear yellow to yellow-brown
PH
6.5 (111g/l, H2O, 20℃)
Water Solubility 
miscible
Sensitive 
Air Sensitive
BRN 
105341
InChIKey
CSDSSGBPEUDDEE-UHFFFAOYSA-N
LogP
0.714 at 20.5℃
CAS DataBase Reference
1121-60-4(CAS DataBase Reference)
NIST Chemistry Reference
2-Pyridinecarboxaldehyde(1121-60-4)
EPA Substance Registry System
2-Pyridinecarboxaldehyde (1121-60-4)
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Safety

Hazard Codes 
Xn,Xi,N,T,F
Risk Statements 
10-22-36/37/38-51/53-46-43-34-23-52
Safety Statements 
7-26-36-61-53-45-36/37/39-29-16-36/37
RIDADR 
UN 1989 3/PG 3
WGK Germany 
3
F 
8-10-23
Hazard Note 
Irritant/Keep Cold/Air Sensitive
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H330Fatal if inhaled

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P62003
Product name
2-Pyridinecarboxaldehyde
Purity
99%
Packaging
25g
Price
$38.8
Updated
2024/03/01
Sigma-Aldrich
Product number
P62003
Product name
2-Pyridinecarboxaldehyde
Purity
99%
Packaging
100g
Price
$82
Updated
2024/03/01
TCI Chemical
Product number
P0425
Product name
2-Pyridinecarboxaldehyde
Purity
>98.0%(GC)
Packaging
25g
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
P0425
Product name
2-Pyridinecarboxaldehyde
Purity
>98.0%(GC)
Packaging
100g
Price
$166
Updated
2024/03/01
Alfa Aesar
Product number
A11391
Product name
Pyridine-2-carboxaldehyde, 99%
Packaging
25g
Price
$38.6
Updated
2024/03/01
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2-Pyridinecarboxaldehyde Chemical Properties,Usage,Production

Chemical Properties

Yellow liquid

Uses

2-Pyridinecarboxaldehyde has been used:

  • To synthesize chitosan based bifunctionalized adsorbent.
  • In the aldol addition reaction with pyruvate in the presence of 2-keto-3-deoxy-6-phosphogluconate aldolase (KDPG) catalyst to form (S)-4-hydroxy-2-keto-4-(2′-pyridyl)butyrate.
  • In the condensation reaction with (S)-(?)-α-methylbenzylamine and (R)-(+)-α-methylbenzylamine to synthesize two chiral (S)-(?)- and (R)-(+)Schiff base compounds.

It can also be combined with thiosemicarbazide to form 2-pyridinecarboxaldehyde thiosemicarbazone ligand (L) which can further complex with Ni(II) and Cu(II) salts (MX) to form [M(L)2X2] complexes.

Definition

ChEBI: 2-Pyridinecarboxaldehyde is a pyridinecarbaldehyde that is pyridine in which the hydrogen at position 2 is replaced by a formyl group.

Synthesis Reference(s)

Synthetic Communications, 23, p. 1775, 1993 DOI: 10.1080/00397919308011276

Purification Methods

Purification is achieved by bubbling sulfur dioxide into a solution of 50g of the aldehyde in 250mL of boiled water, under nitrogen, at 0o, until precipitation is complete. The bisulfite addition compound is filtered off rapidly and, after washing with a little water, is refluxed in 17% HCl (200mL) under nitrogen until a clear solution is obtained. Neutralisation with NaHCO3 and extraction with ether separated the aldehyde which is recovered by drying the extract, then distilling twice, under nitrogen. [Kyte et al. J Chem Soc 4454 1960, Beilstein 21 I 287, 21 III/IV 3495, 21/7 V 293.]

2-Pyridinecarboxaldehyde Preparation Products And Raw materials

Raw materials

acetonitrile N,N-Dimethylformamide Acetone 2-Picoline 2-Bromopyridine Sodium sulfate Sodium chloride Toluene Chromium(VI) oxide Tetrahydrofuran Diethyl ether Hydrochloric acid Dichloromethane Methanol Pyridine PETROLEUM ETHER n-Butyllithium

Preparation Products

PYRIDIN-2-YLMETHYL-HYDRAZINE 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4
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2-Pyridinecarboxaldehyde Suppliers

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View Lastest Price from 2-Pyridinecarboxaldehyde manufacturers

Hebei Fengjia New Material Co., Ltd
Product
2-Pyridinecarboxaldehyde 1121-60-4
Price
US $6.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100000
Release date
2024-08-14
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
2-Pyridinecarboxaldehyde 1121-60-4
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000Ton
Release date
2024-08-13
Hebei Dangtong Import and export Co LTD
Product
2-Pyridinecarboxaldehyde 1121-60-4
Price
US $122.00-110.00/kilograms
Min. Order
100kilograms
Purity
99%
Supply Ability
100tons
Release date
2023-02-17

1121-60-4, 2-PyridinecarboxaldehydeRelated Search:

3-PYRIDINECARBOXALDEHYDE Pyridine hydrochloride 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Pyridine Pyridine sulfur trioxide Pyridine-2-carbonyl chloride hydrochloride Pyridine-4-boronic acid 3-Pyridylboronic acid 2-(Hydroxymethyl)pyridine 2-Picolinic acid 4-Cyanopyridine 2,6-Pyridinedicarbonitrile 3,4-Pyridinedicarboxylic acid 2-Cyanopyridine Quinaldic acid PICOLINIC ACID N-OXIDE Pyridine-2,6-dicarboxylic acid 2-Acetylpyridine

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