5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Product Name: 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
CAS No.: 29682-15-3
Chemical Name: 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
Synonyms: METHYL 5-BROMOPICOLINATE;METHYL 5-BROMOPYRIDINE-2-CARBOXYLATE;5-Bromopyridine-2-carboxyL;5-broMopicolinic acid Methyl ester;Methyl-5-Bromopyridine-2-Carboxlate;METHYL 5-BROMO-2-PYRIDINECARBOXYLATE;Methyl 5-Bromopyridine-2-carboxylate >Methyl 5-bromopyridine-2-carboxylate, 98+%;Methyl 5-BroMopyridine-2-carboxylate, 97+%;5-bromopyridine-2-carboxylate methyl ester
CBNumber: CB0777922
Molecular Formula: C7H6BrNO2
Formula Weight: 216.03
MOL File: 29682-15-3.mol

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5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Property

Melting point:: 101-103°C
Boiling point:: 290.9±20.0 °C(Predicted)
Density: 1.579±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: -0.67±0.10(Predicted)
color: White to Almost white
Water Solubility: Soluble in water.
InChI: InChI=1S/C7H6BrNO2/c1-11-7(10)6-3-2-5(8)4-9-6/h2-4H,1H3
InChIKey: JEURNBCYNWNADN-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=C(Br)C=C1
CAS DataBase Reference: 29682-15-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36
Safety Statements: 26-37
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003613
Product name: methyl 5-bromopyridine-2-carboxylate
Purity: AldrichCPR
Packaging: 250mg
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: M2614
Product name: Methyl 5-Bromopyridine-2-carboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: M2614
Product name: Methyl 5-Bromopyridine-2-carboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $60
Updated: 2025/07/31

TRC

Product number: M296105
Product name: Methyl5-bromopicolinate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: OR13058
Product name: Methyl 5-Bromopyridine-2-carboxylate
Packaging: 1g
Price: $15
Updated: 2021/12/16

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5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 5-bromopyridine-2-carboxylate is used as an organic chemical synthesis intermediate.

Synthesis

67-56-1

30766-11-1

29682-15-3

Example 89 - Preparation of Intermediate 25: The synthesis of Intermediate 25 followed the following general procedure. To a solution of 5-bromopyridine-2-carboxylic acid (50.0 g, 0.247 mol, 1.0 eq.) in anhydrous methanol (400 mL) cooled to 0 °C was added thionyl chloride (107.0 mL, 2.47 mol, 10.0 eq.) dropwise. The reaction mixture was slowly warmed to room temperature and subsequently heated at 50 °C for 12 hours. The reaction process was monitored by thin layer chromatography (TLC) and liquid chromatography-mass spectrometry (LC-MS). After completion of the reaction, the reaction mixture was concentrated under reduced pressure to give a white solid residue. The residue was slowly quenched with saturated sodium bicarbonate solution and the white solid was collected by filtration to afford the target product methyl 5-bromopyridine-2-carboxylate (43.0 g, 80% yield). The product was characterized by mass spectrometry (m/z 216.14) and nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, DMSO): δ 8.86 (d, J=1.9 Hz, 1H), 8.28 (dd, J=8.4,2.4 Hz, 1H), 8.00 (d, J=8.4 Hz, 1H), 3.89 (s, 3H) ppm.

References

[1] Patent: WO2018/126072, 2018, A1. Location in patent: Paragraph 0246; 0247
[2] Patent: WO2012/76898, 2012, A1. Location in patent: Page/Page column 64-65
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 22, p. 4780 - 4784
[4] Patent: WO2016/44662, 2016, A1. Location in patent: Paragraph 00379-00380
[5] Patent: CN103360407, 2016, B. Location in patent: Paragraph 0135-0137

5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Suppliers

Americas 1 China 248 Europe 3 Germany 3 India 13 Japan 1 South Korea 1 United Kingdom 7 United States 37 Global 314

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View Lastest Price from 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 29682-15-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

Shaanxi Dideu New Materials Co. Ltd

Product: 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 29682-15-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-02-17

Henan Fengda Chemical Co., Ltd

Product: 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 29682-15-3
Price: US $6.00-0.20/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-03

29682-15-3, 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTERRelated Search:

Methyl 5-bromonicotinate Methyl 5-broMothiophene-3-carboxylate METHYL 5-BROMO-2-FUROATE 5-Bromo-6-methoxynicotinic acid methyl ester Methyl 5-bromo-2-chloropyridine-3-carboxylate Methyl-5-bromo-2 pyrimidine carboxylate Methyl 5-Bromo-2-Methyl-2H-1,2,3-triazole-4-carboxylate 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE METHYL 5-BROMO-2-IODOBENZOATE Methyl 5-bromo-6-chloropyridine-3-carboxylate METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE 5-BROMO-2-BROMOMETHYL-BENZOIC ACID METHYL ESTER methyl 5-bromo-1H-pyrrole-2-carboxylate Methyl 5-bromo-2-formylbenzoate, 98% METHYL 5-BROMOSALICYLATE Methyl 5-broMo-1H-pyrazole-3-carboxylate Methyl 5-Bromo-1-methyl-1H-1,2,3-triazole-4-carboxylate METHYL 5-BROMOPYRAZINE-2-CARBOXYLATE

Methyl 5-bromopyridine-2-carboxylate, 98+%

5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTE

Methyl 5-bromopicolinate, 5-Bromo-2-(methoxycarbonyl)pyridine

5-broMopicolinic acid Methyl ester

Methyl 5-BroMopyridine-2-carboxylate, 97+%

5-bromopyridin-2-carboxylic acid methyl ester

METHYL 5-BROMO-2-PYRIDINECARBOXYLATE

METHYL 5-BROMOPICOLINATE

METHYL 5-BROMOPYRIDINE-2-CARBOXYLATE

5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

5-Bromopyridine-2-carboxyL

Methyl 5-Bromopyridine-2-carboxylate &gt

2-Pyridinecarboxylic acid, 5-bromo-, methyl ester

5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH

Methyl-5-Bromopyridine-2-Carboxlate

2-Pyridinecarboxylic acid, 5-bromo-, methyl ester (9CI, ACI)

5-bromo-2-Pyridinecarboxylic acid methyl ester (9CI ACI)

5-bromopyridine-2-carboxylate methyl ester

29682-15-3

Quinolines

Boronic Acid

blocks

Bromides

Carboxes

Pyridines

Pyridine

Pyridine Series