5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Product Name
- 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 29682-15-3
- Chemical Name
- 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- METHYL 5-BROMOPICOLINATE;METHYL 5-BROMOPYRIDINE-2-CARBOXYLATE;5-Bromopyridine-2-carboxyL;5-broMopicolinic acid Methyl ester;Methyl-5-Bromopyridine-2-Carboxlate;METHYL 5-BROMO-2-PYRIDINECARBOXYLATE;Methyl 5-Bromopyridine-2-carboxylate >Methyl 5-bromopyridine-2-carboxylate, 98+%;Methyl 5-BroMopyridine-2-carboxylate, 97+%;5-bromopyridine-2-carboxylate methyl ester
- CBNumber
- CB0777922
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 29682-15-3.mol
5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Property
- Melting point:
- 101-103°C
- Boiling point:
- 290.9±20.0 °C(Predicted)
- Density
- 1.579±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- -0.67±0.10(Predicted)
- color
- White to Almost white
- Water Solubility
- Soluble in water.
- InChI
- InChI=1S/C7H6BrNO2/c1-11-7(10)6-3-2-5(8)4-9-6/h2-4H,1H3
- InChIKey
- JEURNBCYNWNADN-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=C(Br)C=C1
- CAS DataBase Reference
- 29682-15-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36
- Safety Statements
- 26-37
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS003613
- Product name
- methyl 5-bromopyridine-2-carboxylate
- Purity
- AldrichCPR
- Packaging
- 250mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- M2614
- Product name
- Methyl 5-Bromopyridine-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- M2614
- Product name
- Methyl 5-Bromopyridine-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $60
- Updated
- 2025/07/31
- Product number
- M296105
- Product name
- Methyl5-bromopicolinate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 072799
- Product name
- Methyl 5-bromopyridine-2-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $82
- Updated
- 2021/12/16
5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl 5-bromopyridine-2-carboxylate is used as an organic chemical synthesis intermediate.
Synthesis
67-56-1
30766-11-1
29682-15-3
Example 89 - Preparation of Intermediate 25: The synthesis of Intermediate 25 followed the following general procedure. To a solution of 5-bromopyridine-2-carboxylic acid (50.0 g, 0.247 mol, 1.0 eq.) in anhydrous methanol (400 mL) cooled to 0 °C was added thionyl chloride (107.0 mL, 2.47 mol, 10.0 eq.) dropwise. The reaction mixture was slowly warmed to room temperature and subsequently heated at 50 °C for 12 hours. The reaction process was monitored by thin layer chromatography (TLC) and liquid chromatography-mass spectrometry (LC-MS). After completion of the reaction, the reaction mixture was concentrated under reduced pressure to give a white solid residue. The residue was slowly quenched with saturated sodium bicarbonate solution and the white solid was collected by filtration to afford the target product methyl 5-bromopyridine-2-carboxylate (43.0 g, 80% yield). The product was characterized by mass spectrometry (m/z 216.14) and nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, DMSO): δ 8.86 (d, J=1.9 Hz, 1H), 8.28 (dd, J=8.4,2.4 Hz, 1H), 8.00 (d, J=8.4 Hz, 1H), 3.89 (s, 3H) ppm.
References
[1] Patent: WO2018/126072, 2018, A1. Location in patent: Paragraph 0246; 0247
[2] Patent: WO2012/76898, 2012, A1. Location in patent: Page/Page column 64-65
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 22, p. 4780 - 4784
[4] Patent: WO2016/44662, 2016, A1. Location in patent: Paragraph 00379-00380
[5] Patent: CN103360407, 2016, B. Location in patent: Paragraph 0135-0137
5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Suppliers
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View Lastest Price from 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 29682-15-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-12
- Product
- 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 29682-15-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-17
- Product
- 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 29682-15-3
- Price
- US $6.00-0.20/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03