5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE

Application

Product Name: 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE
CAS No.: 913836-17-6
Chemical Name: 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE
Synonyms: METHYL 5-BROMO-2-HYDROXYISONICOTINATE;Methyl 5-bromo-2-hydroxyisonicotinate 98%;5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE;Methyl 5-bromo-2-oxo-1h-pyridine-4-carboxylate;METHYL 5-BROMO-2-HYDROXY-4-PYRIDINECARBOXYLATE;Methyl 5-broMo-2-hydroxypyridine-4-carboxylate;Methyl 5-broMo-2-oxo-1,2-dihydropyridine-4-carboxylate;5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE ISO 9001：2015 REACH;5-Bromo-1,2-dihydro-2-oxo-pyridin-4-carboxylic acid methyl ester;4-Pyridinecarboxylic acid, 5-broMo-1,2-dihydro-2-oxo-, Methyl ester
CBNumber: CB2842082
Molecular Formula: C7H6BrNO3
Formula Weight: 232.03
MOL File: 913836-17-6.mol

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5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE Property

Boiling point:: 325.3±42.0 °C(Predicted)
Density: 1.737±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 8.96±0.10(Predicted)
form: solid
color: yellow

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M296548
Product name: Methyl5-Bromo-2-hydroxyisonicotinate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: W9383
Product name: Methyl5-bromo-2-hydroxyisonicotinate
Packaging: 1g
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-9-X7
Product name: Methyl 5-bromo-2-hydroxyisonicotinate
Purity: 98%
Packaging: 1g
Price: $152
Updated: 2021/12/16

AK Scientific

Product number: W9383
Product name: Methyl5-bromo-2-hydroxyisonicotinate
Packaging: 5g
Price: $290
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-9-X7
Product name: Methyl 5-bromo-2-hydroxyisonicotinate
Purity: 98%
Packaging: 5G
Price: $544
Updated: 2021/12/16

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5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE Chemical Properties,Usage,Production

Application

5-Bromo-2-hydroxyisonicotinic acid methyl ester is a carboxylic acid ester derivative, mainly used as a pharmaceutical intermediate.

Synthesis

882499-87-8

913836-17-6

Step A: Synthesis of methyl 5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate-II To a stirred solution of concentrated H2SO4 (50 mL, 0.668 mol) in water (500 mL) was added methyl 2-amino-5-bromoisonicotinate (I, 50 g, 0.226 mol). The resulting clarified brown solution was cooled to 0°C. A solution of NaNO2 (50 g, 0.668 mol) in water (150 mL) was added slowly and dropwise to the mixture at 0 °C using an addition funnel. During the reaction, vigorous bubble production was observed, accompanied by the escape of N2 gas. The reaction mixture was gradually warmed to room temperature and stirring was continued at room temperature for 30 minutes. Upon completion of the reaction, the solid product was collected by filtration and washed sequentially with water (3 x 150 mL) and hexane (2 x 100 mL) to give a yellow solid product (48.0 g, 93% yield). Product characterization data: 1H NMR (DMSO-d6, 400 MHz), δ (ppm): 7.62 (s, 1H), 6.90 (s, 1H), 5.0 (br, 1H), 3.98 (s, 3H). MS (ESI): mass calculated value C7H7BrN2O2, 232.01; m/z found, 234 [M + 2H]+.

References

[1] Patent: US2018/282345, 2018, A1. Location in patent: Paragraph 0180

5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE Suppliers

China 95 Germany 1 India 1 United Kingdom 2 United States 13 Global 112

J & K SCIENTIFIC LTD.

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View Lastest Price from 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE 913836-17-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Dideu Industries Group Limited

Product: 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE 913836-17-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-28

Career Henan Chemical Co

Product: 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE 913836-17-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-03

913836-17-6, 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONERelated Search:

2-Bromopropane METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE Methyl 5-bromo-6-chloropyridine-3-carboxylate METHYL 5-BROMO-2-IODOBENZOATE Methyl 5-Bromo-2-Methyl-2H-1,2,3-triazole-4-carboxylate Methyl-5-bromo-2 pyrimidine carboxylate Methyl 5-bromo-2-chloropyridine-3-carboxylate METHYL 5-BROMO-2-FUROATE 5-Bromo-6-methoxynicotinic acid methyl ester 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 5-BROMO-2-BROMOMETHYL-BENZOIC ACID METHYL ESTER methyl 5-bromo-1H-pyrrole-2-carboxylate Methyl 5-bromo-2-formylbenzoate, 98% METHYL 5-BROMOSALICYLATE Methyl 5-broMo-1H-pyrazole-3-carboxylate Methyl 5-Bromo-1-methyl-1H-1,2,3-triazole-4-carboxylate METHYL 5-BROMOPYRAZINE-2-CARBOXYLATE 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester

METHYL 5-BROMO-2-HYDROXY-4-PYRIDINECARBOXYLATE

METHYL 5-BROMO-2-HYDROXYISONICOTINATE

Methyl 5-Bromo-2-hydroxypyridine-4-carboxylate, 5-Bromo-4-methoxycarbonyl-2(1H)-pyridinone

Methyl 5-bromo-2-hydroxyisonicotinate 98%

Methyl 5-broMo-2-hydroxypyridine-4-carboxylate

Methyl 5-broMo-2-oxo-1,2-dihydropyridine-4-carboxylate

Methyl 5-bromo-2-hydroxypyridine-4-carboxylate, 5-Bromo-2-hydroxy-4-(methoxycarbonyl)pyridine

5-Bromo-1,2-dihydro-2-oxo-pyridin-4-carboxylic acid methyl ester

4-Pyridinecarboxylic acid, 5-broMo-1,2-dihydro-2-oxo-, Methyl ester

Methyl 5-bromo-2-oxo-1h-pyridine-4-carboxylate

5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE

5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE ISO 9001：2015 REACH

913836-17-6

913863-17-6

120034-05-2

blocks

Pyridines