Methyl-5-bromo-2 pyrimidine carboxylate

Product Name: Methyl-5-bromo-2 pyrimidine carboxylate
CAS No.: 89581-38-4
Chemical Name: Methyl-5-bromo-2 pyrimidine carboxylate
Synonyms: Methyl 5-Bromopyrimidine-2-carboxylate;5-Bromo-pyrimidine-2-carboxylic acid methyl ester;5-Bromopyrimidine-2-carboxylate;Methyl-5-bromo-2 pyrimidine carboxylate;Methyl 5-bromopyrimidine-2- carboxylate, 98%;5-BroMopyriMidin-2-carboxylic acid Methyl ester;5-Bromo-2-pyrimidinecarboxylic acid methyl ester;2-PyriMidinecarboxylic acid, 5-broMo-, Methyl ester;Methyl-5-bromo-2 pyrimidine carboxylate ISO 9001：2015 REACH;5-Bromo-2-(methoxycarbonyl)pyrimidine, 5-Bromo-2-(methoxycarbonyl)-1,3-diazine
CBNumber: CB21570328
Molecular Formula: C6H5BrN2O2
Formula Weight: 217.02
MOL File: 89581-38-4.mol

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Methyl-5-bromo-2 pyrimidine carboxylate Property

Melting point:: 149°C(lit.)
Boiling point:: 314.4±34.0 °C(Predicted)
Density: 1.669
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
pka: -2.81±0.22(Predicted)
form: Solid
color: White
InChI: InChI=1S/C6H5BrN2O2/c1-11-6(10)5-8-2-4(7)3-9-5/h2-3H,1H3
InChIKey: XILAKTMDKMVJQV-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=C(Br)C=N1
CAS DataBase Reference: 89581-38-4

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2910
Product name: Methyl 5-Bromopyrimidine-2-carboxylate
Purity: >98.0%(GC)
Packaging: 200mg
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: M2910
Product name: Methyl 5-Bromopyrimidine-2-carboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $100
Updated: 2025/07/31

TRC

Product number: B687950
Product name: 5-Bromopyrimidine-2-carboxylicAcidMethylEster
Packaging: 1g
Price: $155
Updated: 2021/12/16

TRC

Product number: B687950
Product name: 5-Bromopyrimidine-2-carboxylicAcidMethylEster
Packaging: 10g
Price: $210
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-9-W1
Product name: Methyl 5-bromopyrimidine-2-carboxylate
Packaging: 5G
Price: $264
Updated: 2021/12/16

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Methyl-5-bromo-2 pyrimidine carboxylate Chemical Properties,Usage,Production

Uses

5-Bromopyrimidine-2-carboxylic Acid Methyl Ester is used in the study of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs)?.

Synthesis

67-56-1

37131-87-6

89581-38-4

5-Bromopyrimidine-2-carboxylic acid (3.22 g, 15.9 mmol) was dissolved in methanol (50 mL) at room temperature and acetyl chloride (4.0 mL, 56.3 mmol) was slowly added. The reaction mixture was heated to reflux, maintained for 15 min and then cooled to room temperature. Subsequently, the reaction mixture was concentrated under reduced pressure to remove the solvent. The concentrated mixture was diluted with saturated sodium bicarbonate solution (30 mL) and ethyl acetate and transferred to a partition funnel for separation. The aqueous phase was extracted repeatedly with ethyl acetate (4 x 30 mL) and all organic phases were combined. The organic phase was washed with saturated brine (1 × 30 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to give methyl 5-bromo-2-pyrimidinecarboxylate (2.30 g, 10.6 mmol, 67% yield) as a white solid. Analyzed by LC/MS (ESI), m/z = 216.9 ([M+H]+) was measured, which is consistent with the calculated value of molecular weight 216.0 for C6H5BrN2O2.

References

[1] Patent: WO2014/138484, 2014, A1. Location in patent: Page/Page column 185; 186
[2] Patent: WO2016/22724, 2016, A1. Location in patent: Page/Page column 328
[3] Patent: WO2005/28452, 2005, A1. Location in patent: Page/Page column 88
[4] Patent: US2010/216806, 2010, A1. Location in patent: Page/Page column 96

Methyl-5-bromo-2 pyrimidine carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl-5-bromo-2 pyrimidine carboxylate Suppliers

Americas 1 China 146 Europe 1 India 5 Japan 1 United Kingdom 1 United States 14 Global 169

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View Lastest Price from Methyl-5-bromo-2 pyrimidine carboxylate manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Methyl-5-bromo-2 pyrimidine carboxylate 89581-38-4
Price: US $30.00-10.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-08-23

Dideu Industries Group Limited

Product: Methyl-5-bromo-2 pyrimidine carboxylate 89581-38-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl-5-bromo-2 pyrimidine carboxylate 89581-38-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

89581-38-4, Methyl-5-bromo-2 pyrimidine carboxylateRelated Search:

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Methyl 5-Bromopyrimidine-2-carboxylate

5-Bromo-pyrimidine-2-carboxylic acid methyl ester

5-BroMopyriMidin-2-carboxylic acid Methyl ester

5-Bromo-2-(methoxycarbonyl)pyrimidine, 5-Bromo-2-(methoxycarbonyl)-1,3-diazine

2-PyriMidinecarboxylic acid, 5-broMo-, Methyl ester

5-Bromopyrimidine-2-carboxylate

Methyl-5-bromo-2 pyrimidine carboxylate

Methyl-5-bromo-2 pyrimidine carboxylate ISO 9001：2015 REACH

5-Bromo-2-pyrimidinecarboxylic acid methyl ester

Methyl 5-bromopyrimidine-2- carboxylate, 98%

89581-38-4

Heterocycle-Pyrimidine series