5-BroMo-3,4-dihydroisoquinolin-1(2H)-one
- Product Name
- 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one
- CAS No.
- 1109230-25-2
- Chemical Name
- 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one
- Synonyms
- 4-dihydroisoquinolin-1(2H)-one;5-Bromo-3,4-dihydroisoquinolin-1(2H);5-BroMo-3,4-dihydroisoquinolin-1(2H)-one;5-bromo-3,4-dihydro-1(2H)-Isoquinolinone;5-Bromo-3,4-dihydro-2H-isoquinolin-1-one;1(2H)-Isoquinolinone, 5-bromo-3,4-dihydro-;5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one
- CBNumber
- CB02549949
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- 1109230-25-2.mol
5-BroMo-3,4-dihydroisoquinolin-1(2H)-one Property
- Melting point:
- 180-183℃
- Boiling point:
- 453.8±45.0 °C(Predicted)
- Density
- 1.559
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.34±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B691363
- Product name
- 5-Bromo-3,4-dihydroisoquinolin-1(2h)-one
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B691363
- Product name
- 5-Bromo-3,4-dihydroisoquinolin-1(2h)-one
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- P000250939
- Product name
- 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $149
- Updated
- 2021/12/16
- Product number
- CS-W006085
- Product name
- 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one
- Packaging
- 5g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- P000250939
- Product name
- 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $594
- Updated
- 2021/12/16
5-BroMo-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Usage,Production
Synthesis
15115-60-3
1109230-25-2
The general procedure for the synthesis of 5-bromo-3,4-dihydroisoquinolin-1(2H)-one using 4-bromoindan-1-one as starting material was as follows: 4-bromoindan-1-one (4.00 g, 18.9 mmol) and methanesulfonic acid (20.2 mL, 310 mmol) were dissolved in dichloromethane (180 mL) at 0 °C, followed by the slow addition of sodium azide (2.46 g, 37.9 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was poured into 10% aqueous sodium hydroxide solution (200 mL) and extracted with dichloromethane (100 mL). The organic layers were combined and dried over anhydrous sodium sulfate, followed by concentration under reduced pressure to remove the solvent. The crude product was purified by recrystallization from ethyl acetate (40 mL) to afford the target compound 5-bromo-3,4-dihydroisoquinolin-1(2H)-one (3.98 g, 17.6 mmol, 93% yield) as a white powder. The product was analyzed by LCMS showing a purity of 96% with a retention time (Rt) of 1.225 min, and electrospray ionization mass spectrometry (ESMS) showing a m/z of 226 ([M+H]+).
References
[1] Patent: WO2014/153055, 2014, A2. Location in patent: Paragraph 0106-0107
[2] Patent: WO2015/20553, 2015, A1. Location in patent: Paragraph 00111-00112
[3] Patent: WO2015/50472, 2015, A1. Location in patent: Paragraph 00109; 00110
[4] Patent: WO2015/50471, 2015, A1. Location in patent: Paragraph 00105; 00106
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 9, p. 2670 - 2674
5-BroMo-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one manufacturers
- Product
- 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one 1109230-25-2
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%； 99%
- Supply Ability
- 1kg; 5kg; 10kg；25kg
- Release date
- 2020-01-07