5-Bromo-3-cyano-2-hydroxypyridine

Product Name: 5-Bromo-3-cyano-2-hydroxypyridine
CAS No.: 405224-22-8
Chemical Name: 5-Bromo-3-cyano-2-hydroxypyridine
Synonyms: 5-bromo-2-hydroxynicotino...;5-Bromo-3-cyano-2(1H)-pyridinone;5-BROMO-2-HYDROXYNICOTINONITRILE;5-BROMO-3-CAYNO-2(1H)-PYRIDINONE;5-BROMO-3-CYANO-2-HYDROXYPYRIDINE;5-Bromo-2-hydroxynicotinonitrile98%;5-Bromo-2-hydroxynicotinonitrile 98%;5-Bromo-3-cyano-2-hydroxypyridine 98%;5-bromo-2-hydroxypyridine-3-carbonitrile;5-BROMO-2-HYDROXY-3-PYRIDINECARBONITRILE
CBNumber: CB3429637
Molecular Formula: C6H3BrN2O
Formula Weight: 199
MOL File: 405224-22-8.mol

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5-Bromo-3-cyano-2-hydroxypyridine Property

Melting point:: 219-221
Boiling point:: 292.1±40.0 °C(Predicted)
Density: 1.84±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 6.87±0.10(Predicted)
color: Beige
InChI: InChI=1S/C6H3BrN2O/c7-5-1-4(2-8)6(10)9-3-5/h1,3H,(H,9,10)
InChIKey: SWTLLSLCDHXNIU-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(Br)C=C1C#N

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Safety

Hazard Codes: Xi
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B683373
Product name: 5-Bromo-3-cyano-2(1H)-pyridinone
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J50864
Product name: 5-Bromo-3-cyano-2(1H)-pyridinone
Packaging: 5g
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 047356
Product name: 5-Bromo-2-hydroxynicotinonitrile
Purity: >95%
Packaging: 1g
Price: $73
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32877
Product name: 5-Bromo-3-cyano-2(1H)-pyridinone
Packaging: 500mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: J50864
Product name: 5-Bromo-3-cyano-2(1H)-pyridinone
Packaging: 10g
Price: $100
Updated: 2021/12/16

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5-Bromo-3-cyano-2-hydroxypyridine Chemical Properties,Usage,Production

Synthesis

20577-27-9

405224-22-8

General procedure for the synthesis of 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile from 2-oxo-1,2-dihydropyridine-3-carbonitrile: 2-oxo-1,2-dihydropyridine-3-carbonitrile (50 mg, 0.42 mmol) and sodium acetate (69 mg, 0.84 mmol) were dissolved in 5 mL of glacial acetic acid at room temperature, and stirred until complete dissolution. Subsequently, bromine (21.5 μL, 0.42 mmol) was slowly added to the solution and the reaction lasted for 2 hours. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the acetic acid. The crude product was purified by column chromatography (using ethyl acetate as eluent) to afford 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile (69 mg, 75% yield) as a yellow solid. Melting point: 216~217°C. 1H NMR (400MHz, CD3COCD3): δ11.70 (s, 1H), 8.22 (d, J = 2.8Hz, 1H), 8.05 (d, J = 2.8Hz, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3251 - 3255
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6578 - 6581
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 9, p. 1577 - 1580
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 20, p. 5578 - 5585
[5] Patent: US2004/19052, 2004, A1. Location in patent: Page/Page column 17

5-Bromo-3-cyano-2-hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-3-cyano-2-hydroxypyridine Suppliers

China 109 Germany 1 India 1 United Kingdom 3 United States 11 Global 125

PharmaBlock Sciences (Nanjing),Inc.

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View Lastest Price from 5-Bromo-3-cyano-2-hydroxypyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE 405224-22-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Henan Fengda Chemical Co., Ltd

Product: 5-Bromo-2-hydroxynicotinonitrile 405224-22-8
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE 405224-22-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

405224-22-8, 5-Bromo-3-cyano-2-hydroxypyridineRelated Search:

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5-BROMO-3-CYANO-2-HYDROXYPYRIDINE

5-BROMO-3-CAYNO-2(1H)-PYRIDINONE

5-BROMO-2-HYDROXY-3-PYRIDINECARBONITRILE

5-BROMO-2-HYDROXYNICOTINONITRILE

5-Bromo-3-cyano-2-hydroxypyridine 98%

5-Bromo-3-cyano-2(1H)-pyridinone

5-bromo-2-hydroxypyridine-3-carbonitrile

5-bromo-2-hydroxynicotino...

5-Bromo-2-hydroxynicotinonitrile 98%

5-Bromo-3-cyano-2-hydroxypyridine, 5-Bromo-2-hydroxypyridine-3-carbonitrile

5-Bromo-2-hydroxynicotinonitrile98%

5-BroMo-2-oxo-2,3-dihydropyridine-3-carbonitrile

5-bromo-2-oxo-1H-pyridine-3-carbonitrile

3-Pyridinecarbonitrile, 5-bromo-1,2-dihydro-2-oxo-

5-BROMO-3-CYANO-2-HYDROXYPYRIDINE ISO 9001：2015 REACH

5-Bromo-1,2-dihydro-2-oxo-3-pyridinecarbonitrile

405224-22-8

alcohol|cyanide| alkyl bromide

blocks

Bromides

Carboxes

Pyridines