2-Hydroxy-3-cyanopyridine

Product Name: 2-Hydroxy-3-cyanopyridine
CAS No.: 20577-27-9
Chemical Name: 2-Hydroxy-3-cyanopyridine
Synonyms: 3-Cyano-2-pyridone;3-Cyano-2-pyridinol;3-CYANO-2(1H)-PYRIDINONE;3-Cyano-1H-pyridin-2-one;2-Hydroxynicotinonitrile;3-Cyanopyridin-2(1H)-one;2-Hydroy-3-cyanopyridine;2-Hydroxy-3-cycnopyridine;2-Hydroxy-3-cyanopyridine;2-HYDROXY-3-PYRIDINECARBONITRILE
CBNumber: CB9141849
Molecular Formula: C6H4N2O
Formula Weight: 120.11
MOL File: 20577-27-9.mol

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2-Hydroxy-3-cyanopyridine Property

Melting point:: 90-94
Boiling point:: 352.3±35.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in dimethyl sulfoxide.
form: Solid
pka: 8.93±0.10(Predicted)
InChI: InChI=1S/C6H4N2O/c7-4-5-2-1-3-8-6(5)9/h1-3H,(H,8,9)
InChIKey: DYUMBFTYRJMAFK-UHFFFAOYSA-N
SMILES: C1(=O)NC=CC=C1C#N
CAS DataBase Reference: 20577-27-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 22-41
Safety Statements: 26-39
RIDADR: UN3439
Hazard Note: Irritant/Keep Cold
HazardClass: 6.1
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: H825140
Product name: 2-Hydroxy-3-cyanopyridine
Packaging: 10g
Price: $135
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 10706
Product name: 2-Hydroxy-3-cyanopyridine
Packaging: 5G
Price: $290
Updated: 2021/12/16

Matrix Scientific

Product number: 153011
Product name: 2-Oxo-2,3-dihydropyridine-3-carbonitrile
Purity: 95%
Packaging: 25g
Price: $334
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC09747
Product name: 3-Cyano-2-hydroxypyridine
Packaging: 25g
Price: $131.25
Updated: 2021/12/16

AK Scientific

Product number: W4330
Product name: 3-Cyano-2-hydroxypyridine
Packaging: 5g
Price: $32
Updated: 2021/12/16

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2-Hydroxy-3-cyanopyridine Chemical Properties,Usage,Production

Chemical Properties

Dark Yellow Solid

Uses

2-Hydroxy-3-cyanopyridine (cas# 20577-27-9) is a compound useful in organic synthesis.

Definition

ChEBI: 3-cyano-2-pyridone is a member of pyridines and a nitrile.

Synthesis

6602-54-6

20577-27-9

The general procedure for the synthesis of 2-oxo-1,2-dihydropyridine-3-carbonitrile from 2-chloro-3-cyanopyridine was as follows: acetic acid (826 mL) was slowly added to 2-chloro-3-cyanopyridine (250 g), and the mixture was subsequently heated to reflux and held for 48 hours. Upon completion of the reaction, the reaction mixture was quenched by careful pouring into an ice-water mixture. The resulting precipitate was collected by filtration, washed well with deionized water and dried under appropriate conditions to give the target product 2-hydroxy-3-cyanopyridine. The yield of this step was 95%. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 12.57 (s, 1H), 8.16 (dd, J = 3.6 Hz, 1H), 7.80 (dd, J = 3.6 Hz, 1H), 6.37 (t, 1H); the mass spectrum (ES) showed m/z of 121.

References

[1] Tetrahedron Letters, 2004, vol. 45, # 35, p. 6633 - 6636
[2] Patent: WO2014/207508, 2014, A1. Location in patent: Page/Page column 55
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 18, p. 7624 - 7643
[4] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5738 - 5746
[5] Synthetic Communications, 2011, vol. 41, # 19, p. 2859 - 2869

2-Hydroxy-3-cyanopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy-3-cyanopyridine Suppliers

Canada 2 China 179 Germany 2 India 3 United Kingdom 5 United States 20 Global 211

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Pure Chemistry Scientific Inc.

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View Lastest Price from 2-Hydroxy-3-cyanopyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Hydroxy-3-cyanopyridine 20577-27-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Henan Fengda Chemical Co., Ltd

Product: 2-Hydroxy-3-cyanopyridine 20577-27-9
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2-Hydroxy-3-cyanopyridine 20577-27-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-15

20577-27-9, 2-Hydroxy-3-cyanopyridineRelated Search:

1H-INDOL-3-OL CHLOROPHOSPHONAZO III 2-Chloro-3-hydroxypyridine 3-Hydroxypyridine 3-Cyanopyridine Protocatechuic acid 2-Hydroxypyridine 3-Aminopyridine 3-Cyano-4,6-dimethyl-2-hydroxypyridine 2-HYDROXY-4-METHOXYMETHYL-6-METHYLNICOTINONITRILE Milrinone RICININE 7'-METHYL-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-6'-CARBONITRILE 3-Cyano-6-methyl-2(1H)-pyridinone 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one 1-Ethyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 2-Hydroxy-3-cyanopyridine ETHYL 2-(6'-CYANO-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-7'-YL)ACETATE

2-Hydroxy-3-cycnopyridine

2-Oxo-2,3-dihydropyridine-3-carbonitrile

3-CYANO-2(1H)-PYRIDINONE

2-HYDROXY-3-PYRIDINECARBONITRILE

2-Hydroxy-3-cyanopyridine

1,2-Dihydro-2-oxopyridine-3-carbonitrile

1,2-Dihydropyridine-2-oxo-3-carbonitrile

3-Cyano-1H-pyridin-2-one

1,2-Dihydro-2-oxopyridine-3-carbonitrile 98%

2-Hydroxypyridine-3-carbonitrile, 3-Cyano-2-hydroxypyridine

1,2-Dihydropyridine-2-oxo-3-carbonitrile98%

2-Hydroxynicotinonitrile

3-Cyanopyridin-2(1H)-one

3-Cyano-2-pyridinol

3-Cyano-2-pyridone

3-Pyridinecarbonitrile, 1,2-dihydro-2-oxo-

2-Hydroxy-3-cyanopyridine ISO 9001：2015 REACH

2-Hydroy-3-cyanopyridine

2-oxo-1,2-dihydropyridine-3-carbonitrile2-hydroxy-3-cyanopyridine

2-Oxo-1,2-dihydropyridin-3-carbonitrile2-hydroxy-3-cyano-pyridine

20577-27-9

200577-27-9

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