5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine

Product Name: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine
CAS No.: 76041-79-7
Chemical Name: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine
Synonyms: 5-BROMO-3-TRIFLUOROMETHYL-2-PYRIDONE;2-hydroxy-5-broMo-3-trifluoropyridine;5-Bromo-3-(trifluoromethyl)pyridin-2-ol;5-Bromo-3-(trifluoromethyl)-2-pyridinol;5-BroMo-3-trifluoroMethyl-1H-pyridin-2-one;5-broMo-3-(trifluoroMethyl)-2(1H)-pyridinone;5-bromo-3-(trifluoromethyl)pyridin-2(1H)-one;5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine;2(1H)-Pyridinone, 5-bromo-3-(trifluoromethyl)-;5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine 98%
CBNumber: CB12504217
Molecular Formula: C6H3BrF3NO
Formula Weight: 241.99
MOL File: 76041-79-7.mol

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5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine Property

Boiling point:: 229.4±40.0 °C(Predicted)
Density: 1.876±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 7.61±0.10(Predicted)
form: Solid
Appearance: White to light brown Solid
InChI: InChI=1S/C6H3BrF3NO/c7-3-1-4(6(8,9)10)5(12)11-2-3/h1-2H,(H,11,12)
InChIKey: OPLCXLXORZDTMX-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(Br)C=C1C(F)(F)F
CAS DataBase Reference: 76041-79-7

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B696280
Product name: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 074821
Product name: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine
Purity: 95+%
Packaging: 1g
Price: $103
Updated: 2021/12/16

Apolloscientific

Product number: PC48328
Product name: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 5g
Price: $120
Updated: 2021/12/16

Apolloscientific

Product number: PC48328
Product name: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 10g
Price: $171
Updated: 2021/12/16

AK Scientific

Product number: W8312
Product name: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine
Packaging: 5g
Price: $182
Updated: 2021/12/16

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5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Synthesis

22245-83-6

76041-79-7

Step 1: 3-(Trifluoromethyl)pyridin-2(1H)-one (25.0 g, 0.15 mol) was dissolved in acetic acid (300 mL) and sodium acetate (15.1 g, 0.18 mol) and bromine (8.6 mL, 0.17 mol) were added sequentially, dropwise. The reaction mixture was stirred at 80°C overnight. After completion of the reaction, the mixture was concentrated, diluted with saturated aqueous sodium bicarbonate and extracted twice with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. Purification by column chromatography (petroleum ether/ethyl acetate = 7/2) afforded the target compound 5-bromo-3-(trifluoromethyl)pyridin-2(1H)-one (P45a) (29.7 g, 80% yield) as a white solid.

References

[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 16, p. 6106 - 6122
[2] Patent: WO2012/139775, 2012, A1. Location in patent: Page/Page column 69-70
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6578 - 6581
[4] Patent: US2013/12491, 2013, A1. Location in patent: Paragraph 0171; 0172

5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine Suppliers

China 107 India 1 United Kingdom 1 United States 10 Global 119

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View Lastest Price from 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine manufacturers

Dideu Industries Group Limited

Product: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine 76041-79-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-26

Career Henan Chemical Co

Product: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine 76041-79-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-26

76041-79-7, 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridineRelated Search:

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5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine

5-Bromo-3-(trifluoromethyl)pyridin-2-ol

5-BROMO-3-TRIFLUOROMETHYL-2-PYRIDONE

2-hydroxy-5-broMo-3-trifluoropyridine

5-BroMo-3-trifluoroMethyl-1H-pyridin-2-one

5-broMo-3-(trifluoroMethyl)-2(1H)-pyridinone

5-Bromo-3-(trifluoromethyl)pyridin-2-ol, 5-Bromo-2-hydroxy-alpha,alpha,alpha-trifluoro-3-picoline

5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine 98%

5-bromo-3-(trifluoromethyl)-1,2-dihydropyridin-2-one

2(1H)-Pyridinone, 5-bromo-3-(trifluoromethyl)-

5-bromo-3-(trifluoromethyl)pyridin-2(1H)-one

5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine ISO 9001：2015 REACH

5-Bromo-3-(trifluoromethyl)-2-pyridinol

76041-79-7

Fluorine series