5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE
- Product Name
- 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE
- CAS No.
- 880094-83-7
- Chemical Name
- 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE
- Synonyms
- Cartenolol EP Impurity B;5-Bromo-3,4-dihydroquinolin-2(1H);5-bromo-3,4-dihydro-2(1H)-Quinolinone;5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE;5-bromo-3,4-dihydro-1H-quinolin-2-one;2(1H)-Quinolinone, 5-bromo-3,4-dihydro-;5-Bromo-1,2,3,4-tetrahydroquinolin-2-one
- CBNumber
- CB51517582
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- 880094-83-7.mol
5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE Property
- Boiling point:
- 372.4±42.0 °C(Predicted)
- Density
- 1.559±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.02±0.20(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B292915
- Product name
- 5-Bromo-3,4-dihydroquinolin-2(1H)-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- P000257994
- Product name
- 5-Bromo-3,4-dihydroquinolin-2(1H)-one
- Purity
- 97%
- Packaging
- 100mg
- Price
- $52
- Updated
- 2021/12/16
- Product number
- P000257994
- Product name
- 5-Bromo-3,4-dihydroquinolin-2(1H)-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- W9033
- Product name
- 5-Bromo-3,4-dihydroquinolin-2(1H)-one
- Packaging
- 100mg
- Price
- $111
- Updated
- 2021/12/16
- Product number
- P000257994
- Product name
- 5-Bromo-3,4-dihydroquinolin-2(1H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE Chemical Properties,Usage,Production
Synthesis
15115-60-3
880094-83-7
The general procedure for the synthesis of 5-bromo-3,4-dihydroquinolin-2(1H)-one from 4-bromoinden-1-one was as follows: a three-phase mixture consisting of sodium azide (18.5 g, 284 mmol), concentrated sulfuric acid (18.8 M, 4.8 mL, 90 mmol), water (36 mL), and chloroform (144 mL) was stirred for 2.5 hours at 0 °C. Upon completion of the reaction, the phases were separated and the organic phase was dried over anhydrous sodium sulfate and filtered. The filtrate was slowly added to a solution of 4-bromoindan-1-one (12.0 g, 56.9 mmol) in chloroform (215 mL). Subsequently, concentrated sulfuric acid (18.8 M, 18.7 mL, 351.6 mmol) was added dropwise over 10 minutes. The reaction mixture was stirred at 45°C for 4 hours, then cooled to room temperature and continued stirring for 20 hours. At the end of the reaction, the mixture was poured into ice (200 g) and neutralized by adding 10% aqueous sodium hydroxide solution (50 mL). The phases were separated and the aqueous phase was extracted with chloroform (100 mL). All organic phases were combined and the solvent was evaporated by drying with anhydrous sodium sulfate. The crude product was purified by recrystallization from ethanol (55 mL) to afford 5-bromo-3,4-dihydroquinolin-2(1H)-one (8.65 g, 38.2 mmol, 67% yield) as an off-white powder. The product was analyzed by LCMS showing a purity of 98% with a retention time (Rt) of 1.290 min and m/z 226 ([M+H]+) detected by ESMS.
References
[1] Patent: WO2014/153055, 2014, A2. Location in patent: Paragraph 0104-0105
[2] Patent: WO2008/130524, 2008, A1. Location in patent: Page/Page column 53
[3] Patent: WO2006/31513, 2006, A2. Location in patent: Page/Page column 51-52
5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE Suppliers
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
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- 7892
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- 021-64968085,64968086-5815,5812; 13472757003
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- +86 21 64968087
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- China
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- 021-61551100
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- 021-61551100
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- China
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- 18049974220
- Fax
- +86 (21) 51062076
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- China
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- 995
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- 18652989687
- Fax
- +86-25-52131256
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- China
- ProdList
- 8878
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- 55
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- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
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- China
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- 39966
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- 60
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- 021-021-56795766
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- +86-21-56795266
- sales@worldyachem.com
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- China
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- 9476
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- 微信 17321281695 18019252918
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- 17321281695
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- China
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- 13391076197
- tombiopharma@163.com
- Country
- China
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- 021-60455363 18019463053
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- 50966098
- sales@coolpharm.com
- Country
- China
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View Lastest Price from 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE manufacturers
- Product
- 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE 880094-83-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE 880094-83-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE 880094-83-7
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09