ChemicalBook > CAS DataBase List > 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE

5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE

Product Name: 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE
CAS No.: 880094-83-7
Chemical Name: 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE
Synonyms: Cartenolol EP Impurity B;5-Bromo-3,4-dihydroquinolin-2(1H);5-bromo-3,4-dihydro-2(1H)-Quinolinone;5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE;5-bromo-3,4-dihydro-1H-quinolin-2-one;2(1H)-Quinolinone, 5-bromo-3,4-dihydro-;5-Bromo-1,2,3,4-tetrahydroquinolin-2-one
CBNumber: CB51517582
Molecular Formula: C9H8BrNO
Formula Weight: 226.07
MOL File: 880094-83-7.mol

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5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE Property

Boiling point:: 372.4±42.0 °C(Predicted)
Density: 1.559±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.02±0.20(Predicted)
Appearance: Off-white to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: B292915
Product name: 5-Bromo-3,4-dihydroquinolin-2(1H)-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: P000257994
Product name: 5-Bromo-3,4-dihydroquinolin-2(1H)-one
Purity: 97%
Packaging: 100mg
Price: $52
Updated: 2021/12/16

Ark Pharm

Product number: P000257994
Product name: 5-Bromo-3,4-dihydroquinolin-2(1H)-one
Purity: 97%
Packaging: 250mg
Price: $72
Updated: 2021/12/16

AK Scientific

Product number: W9033
Product name: 5-Bromo-3,4-dihydroquinolin-2(1H)-one
Packaging: 100mg
Price: $111
Updated: 2021/12/16

Ark Pharm

Product number: P000257994
Product name: 5-Bromo-3,4-dihydroquinolin-2(1H)-one
Purity: 97%
Packaging: 1g
Price: $169
Updated: 2021/12/16

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5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE Chemical Properties,Usage,Production

Synthesis

15115-60-3

880094-83-7

The general procedure for the synthesis of 5-bromo-3,4-dihydroquinolin-2(1H)-one from 4-bromoinden-1-one was as follows: a three-phase mixture consisting of sodium azide (18.5 g, 284 mmol), concentrated sulfuric acid (18.8 M, 4.8 mL, 90 mmol), water (36 mL), and chloroform (144 mL) was stirred for 2.5 hours at 0 °C. Upon completion of the reaction, the phases were separated and the organic phase was dried over anhydrous sodium sulfate and filtered. The filtrate was slowly added to a solution of 4-bromoindan-1-one (12.0 g, 56.9 mmol) in chloroform (215 mL). Subsequently, concentrated sulfuric acid (18.8 M, 18.7 mL, 351.6 mmol) was added dropwise over 10 minutes. The reaction mixture was stirred at 45°C for 4 hours, then cooled to room temperature and continued stirring for 20 hours. At the end of the reaction, the mixture was poured into ice (200 g) and neutralized by adding 10% aqueous sodium hydroxide solution (50 mL). The phases were separated and the aqueous phase was extracted with chloroform (100 mL). All organic phases were combined and the solvent was evaporated by drying with anhydrous sodium sulfate. The crude product was purified by recrystallization from ethanol (55 mL) to afford 5-bromo-3,4-dihydroquinolin-2(1H)-one (8.65 g, 38.2 mmol, 67% yield) as an off-white powder. The product was analyzed by LCMS showing a purity of 98% with a retention time (Rt) of 1.290 min and m/z 226 ([M+H]+) detected by ESMS.

References

[1] Patent: WO2014/153055, 2014, A2. Location in patent: Paragraph 0104-0105
[2] Patent: WO2008/130524, 2008, A1. Location in patent: Page/Page column 53
[3] Patent: WO2006/31513, 2006, A2. Location in patent: Page/Page column 51-52

5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE 880094-83-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE 880094-83-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE 880094-83-7
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

880094-83-7, 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONERelated Search:

5-BROMO-3-METHYL-1H-PYRAZOLE 5-BROMO-3-FORMYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 5-BROMO-3-CHLORO-1H-INDAZOLE 5-Bromo-3-cyanoindole 5-BroMo-3,3-diMethylindoline 5-Bromo-3-chlorophenylene-1,2-diamine, 5-Bromo-3-chloro-1,2-diaminobenzene 1H-Indole, 5-broMo-3-iodo- Methyl-5-bromo-2 pyrimidine carboxylate 5-BROMO-3-IODO-PYRIDIN-2-OL 5-BROMO-3-IODO-2-METHOXYPYRIDINE 5-Bromo-3-(trifluoromethyl)-2-pyridinecarbonitrile 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine 2-Amino-3-Difluoromethoxy-5-Bromopyridine 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one 5-Bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine N-(3-Bromo-2-methylphenyl)acetamide 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE 5-BROMOQUINOLINE-2,4(1H,3H)-DIONE

5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE

5-bromo-3,4-dihydro-2(1H)-Quinolinone

5-Bromo-3,4-dihydroquinolin-2(1H)

5-Bromo-1,2,3,4-tetrahydroquinolin-2-one

5-bromo-3,4-dihydro-1H-quinolin-2-one

2(1H)-Quinolinone, 5-bromo-3,4-dihydro-

Cartenolol EP Impurity B

880094-83-7

88094-83-7