ChemicalBook > CAS DataBase List > Methyl-5-bromo-2 pyrimidine carboxylate

Methyl-5-bromo-2 pyrimidine carboxylate

Product Name
Methyl-5-bromo-2 pyrimidine carboxylate
CAS No.
89581-38-4
Chemical Name
Methyl-5-bromo-2 pyrimidine carboxylate
Synonyms
Methyl 5-Bromopyrimidine-2-carboxylate;5-Bromo-pyrimidine-2-carboxylic acid methyl ester;5-Bromopyrimidine-2-carboxylate;Methyl-5-bromo-2 pyrimidine carboxylate;Methyl 5-bromopyrimidine-2- carboxylate, 98%;5-BroMopyriMidin-2-carboxylic acid Methyl ester;5-Bromo-2-pyrimidinecarboxylic acid methyl ester;2-PyriMidinecarboxylic acid, 5-broMo-, Methyl ester;Methyl-5-bromo-2 pyrimidine carboxylate ISO 9001：2015 REACH;5-Bromo-2-(methoxycarbonyl)pyrimidine, 5-Bromo-2-(methoxycarbonyl)-1,3-diazine
CBNumber
CB21570328
Molecular Formula
C6H5BrN2O2
Formula Weight
217.02
MOL File
89581-38-4.mol
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Methyl-5-bromo-2 pyrimidine carboxylate Property

Melting point:
149°C(lit.)
Boiling point:
314.4±34.0 °C(Predicted)
Density 
1.669
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
pka
-2.81±0.22(Predicted)
form 
Solid
color 
White
InChI
InChI=1S/C6H5BrN2O2/c1-11-6(10)5-8-2-4(7)3-9-5/h2-3H,1H3
InChIKey
XILAKTMDKMVJQV-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)=NC=C(Br)C=N1
CAS DataBase Reference
89581-38-4
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2910
Product name
Methyl 5-Bromopyrimidine-2-carboxylate
Purity
>98.0%(GC)
Packaging
200mg
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
M2910
Product name
Methyl 5-Bromopyrimidine-2-carboxylate
Purity
>98.0%(GC)
Packaging
1g
Price
$100
Updated
2025/07/31
TRC
Product number
B687950
Product name
5-Bromopyrimidine-2-carboxylicAcidMethylEster
Packaging
1g
Price
$155
Updated
2021/12/16
TRC
Product number
B687950
Product name
5-Bromopyrimidine-2-carboxylicAcidMethylEster
Packaging
10g
Price
$210
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-9-W1
Product name
Methyl 5-bromopyrimidine-2-carboxylate
Packaging
5G
Price
$264
Updated
2021/12/16
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Methyl-5-bromo-2 pyrimidine carboxylate Chemical Properties,Usage,Production

Uses

5-Bromopyrimidine-2-carboxylic Acid Methyl Ester is used in the study of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs)?.

Synthesis

67-56-1

37131-87-6

89581-38-4

5-Bromopyrimidine-2-carboxylic acid (3.22 g, 15.9 mmol) was dissolved in methanol (50 mL) at room temperature and acetyl chloride (4.0 mL, 56.3 mmol) was slowly added. The reaction mixture was heated to reflux, maintained for 15 min and then cooled to room temperature. Subsequently, the reaction mixture was concentrated under reduced pressure to remove the solvent. The concentrated mixture was diluted with saturated sodium bicarbonate solution (30 mL) and ethyl acetate and transferred to a partition funnel for separation. The aqueous phase was extracted repeatedly with ethyl acetate (4 x 30 mL) and all organic phases were combined. The organic phase was washed with saturated brine (1 × 30 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to give methyl 5-bromo-2-pyrimidinecarboxylate (2.30 g, 10.6 mmol, 67% yield) as a white solid. Analyzed by LC/MS (ESI), m/z = 216.9 ([M+H]+) was measured, which is consistent with the calculated value of molecular weight 216.0 for C6H5BrN2O2.

References

[1] Patent: WO2014/138484, 2014, A1. Location in patent: Page/Page column 185; 186
[2] Patent: WO2016/22724, 2016, A1. Location in patent: Page/Page column 328
[3] Patent: WO2005/28452, 2005, A1. Location in patent: Page/Page column 88
[4] Patent: US2010/216806, 2010, A1. Location in patent: Page/Page column 96

Methyl-5-bromo-2 pyrimidine carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl-5-bromo-2 pyrimidine carboxylate manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Methyl-5-bromo-2 pyrimidine carboxylate 89581-38-4
Price
US $30.00-10.00/kg
Min. Order
10kg
Purity
99%
Supply Ability
100000kg
Release date
2024-08-23
Dideu Industries Group Limited
Product
Methyl-5-bromo-2 pyrimidine carboxylate 89581-38-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-01
Zhuozhou Wenxi import and Export Co., Ltd
Product
Methyl-5-bromo-2 pyrimidine carboxylate 89581-38-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

89581-38-4, Methyl-5-bromo-2 pyrimidine carboxylateRelated Search:

Ethyl-5-bromopyrimidine-2-carboxylate 5-bromo-2-pyridinecarboxylic acid ethyl ester 5-BROMO-3-(BROMOMETHYL)PYRIDIN-2-AMINE HYDROBROMIDE 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE 5-BROMO-3-METHYL-1H-PYRAZOLE 5-BROMO-3-FORMYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 5-BROMO-3-CHLORO-1H-INDAZOLE 5-Bromo-3-cyanoindole 5-BroMo-3,3-diMethylindoline 5-Bromo-3-chlorophenylene-1,2-diamine, 5-Bromo-3-chloro-1,2-diaminobenzene 1H-Indole, 5-broMo-3-iodo- 5-BROMO-3-IODO-PYRIDIN-2-OL 5-BROMO-3-IODO-2-METHOXYPYRIDINE 5-Bromo-3-(trifluoromethyl)-2-pyridinecarbonitrile 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine 2-Amino-3-Difluoromethoxy-5-Bromopyridine 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one 5-Bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine

  • Methyl 5-Bromopyrimidine-2-carboxylate
  • 5-Bromo-pyrimidine-2-carboxylic acid methyl ester
  • 5-BroMopyriMidin-2-carboxylic acid Methyl ester
  • 5-Bromo-2-(methoxycarbonyl)pyrimidine, 5-Bromo-2-(methoxycarbonyl)-1,3-diazine
  • 2-PyriMidinecarboxylic acid, 5-broMo-, Methyl ester
  • 5-Bromopyrimidine-2-carboxylate
  • Methyl-5-bromo-2 pyrimidine carboxylate
  • Methyl-5-bromo-2 pyrimidine carboxylate ISO 9001：2015 REACH
  • 5-Bromo-2-pyrimidinecarboxylic acid methyl ester
  • Methyl 5-bromopyrimidine-2- carboxylate, 98%
  • 89581-38-4
  • Heterocycle-Pyrimidine series