5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester

Product Name: 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester
CAS No.: 1214336-41-0
Chemical Name: 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester
Synonyms: Methyl 5-broMo-3-chloropicolinate;Methyl 5-broMo-3-chloropyridine-2-carboxylate;5-Bromo-3-Chloropyridinecarboxylic acid methyl ester;5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester;3-chloro-5-bromo-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 5-bromo-3-chloro-, methyl ester;5-Bromo-3-chloro-2-(methoxycarbonyl)pyridine, Methyl 5-bromo-3-chloropicolinate
CBNumber: CB62547048
Molecular Formula: C7H5BrClNO2
Formula Weight: 250.48
MOL File: 1214336-41-0.mol

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5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester Property

Boiling point:: 311℃
Density: 1.684
Flash point:: 142℃
storage temp.: Inert atmosphere,Room Temperature
pka: -3.26±0.10(Predicted)
form: crystalline powder
color: White
InChI: InChI=1S/C7H5BrClNO2/c1-12-7(11)6-5(9)2-4(8)3-10-6/h2-3H,1H3
InChIKey: QBNSPYFGGCZDJG-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=C(Br)C=C1Cl

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B682160
Product name: 5-Bromo-3-chloro-2-pyridinecarboxylicAcidMethylEster
Packaging: 1g
Price: $295
Updated: 2021/12/16

TRC

Product number: B682160
Product name: 5-Bromo-3-chloro-2-pyridinecarboxylicAcidMethylEster
Packaging: 5G
Price: $550
Updated: 2021/12/16

Matrix Scientific

Product number: 188106
Product name: Methyl 5-bromo-3-chloropyridine-2-carboxylate
Packaging: 25g
Price: $750
Updated: 2021/12/16

Matrix Scientific

Product number: 188106
Product name: Methyl 5-bromo-3-chloropyridine-2-carboxylate
Packaging: 10g
Price: $376
Updated: 2021/12/16

AK Scientific

Product number: 3840AA
Product name: Methyl5-bromo-3-chloropicolinate
Packaging: 5g
Price: $150
Updated: 2021/12/16

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5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester Chemical Properties,Usage,Production

Uses

5-Bromo-3-chloro-2-pyridinecarboxylic Acid Methyl Ester is an intermediate used to prepare aminopyridinyldihydrooxazine derivatives for use as BACE-1 and/or BACE-2 inhibitors.

Synthesis

67-56-1

1189513-51-6

1214336-41-0

To a solution of dichloromethane (700 mL) containing traces of turbid 5-bromo-3-chloropyridine-2-carboxylic acid (60 g, 183.2 mmol), N,N-dimethylformamide (1 mL) and oxalyl chloride (24.9 mL, 286.9 mmol) were added slowly and dropwise. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the resulting yellow solution was cooled to 10 °C and methanol (30.8 mL, 761.3 mmol) was slowly added dropwise at this temperature, keeping the reaction temperature between 15 °C and 20 °C. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature overnight. At the end of the reaction, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate solution, followed by washing the organic layer with brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to give methyl 5-bromo-3-chloro-2-pyridinecarboxylate (55 g) as a yellow solid, which could be used in the next reaction without further purification.LCMS (Method B): m/z 250/252/254 (M + 1), retention time 1.12 min.

References

[1] Patent: WO2015/160636, 2015, A1. Location in patent: Page/Page column 164
[2] Patent: WO2015/160634, 2015, A1. Location in patent: Page/Page column 145
[3] Patent: WO2016/46071, 2016, A1. Location in patent: Page/Page column 61
[4] Patent: WO2016/87265, 2016, A1. Location in patent: Page/Page column 62; 63
[5] Patent: WO2016/87257, 2016, A1. Location in patent: Page/Page column 67-68

5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester Suppliers

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View Lastest Price from 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester 1214336-41-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-03

Henan Fengda Chemical Co., Ltd

Product: 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester 1214336-41-0
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Career Henan Chemical Co

Product: 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester 1214336-41-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

1214336-41-0, 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl esterRelated Search:

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Methyl 5-broMo-3-chloropicolinate

Methyl 5-broMo-3-chloropyridine-2-carboxylate

5-Bromo-3-chloro-2-(methoxycarbonyl)pyridine, Methyl 5-bromo-3-chloropicolinate

5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester

3-chloro-5-bromo-pyridine-2-carboxylic acid methyl ester

2-Pyridinecarboxylic acid, 5-bromo-3-chloro-, methyl ester

5-Bromo-3-Chloropyridinecarboxylic acid methyl ester

1214336-41-0