Methyl 5-bromonicotinate
- Product Name
- Methyl 5-bromonicotinate
- CAS No.
- 29681-44-5
- Chemical Name
- Methyl 5-bromonicotinate
- Synonyms
- BUTTPARK 37\04-20;METHYL 5-BROMONICOTINATE;Methyl5-Bromonicotinate>5-bromopyridine-3-carboxyL;Methyl 5-bromonicotinate,98%;Methyl 5-bromonicotinate, 97%,;5-Bromonictinic acid ethyl ester;5-BROMONICOTIC ACID METHYL ESTER;5-BROMO NICOTINIC ACID METHYL ESTER;3-(Methoxycarbonyl)-5-bromopyridine
- CBNumber
- CB6384490
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 29681-44-5.mol
Methyl 5-bromonicotinate Property
- Melting point:
- 96-100 °C
- Boiling point:
- 241.7±20.0 °C(Predicted)
- Density
- 1.579±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- solid
- pka
- 0.84±0.20(Predicted)
- color
- White
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C7H6BrNO2/c1-11-7(10)5-2-6(8)4-9-3-5/h2-4H,1H3
- InChIKey
- AAJZXPWBILCHAW-UHFFFAOYSA-N
- SMILES
- C1=NC=C(Br)C=C1C(OC)=O
- CAS DataBase Reference
- 29681-44-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 37/38-41-36/37/38
- Safety Statements
- 26-39-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 657425
- Product name
- Methyl 5-bromopyridine-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $99.1
- Updated
- 2024/03/01
- Product number
- M2008
- Product name
- Methyl 5-Bromonicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- M2008
- Product name
- Methyl 5-Bromonicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $90
- Updated
- 2024/03/01
- Product number
- B20908
- Product name
- Methyl 5-bromonicotinate, 97%
- Packaging
- 5g
- Price
- $98.65
- Updated
- 2024/03/01
- Product number
- B20908
- Product name
- Methyl 5-bromonicotinate, 97%
- Packaging
- 1g
- Price
- $24.2
- Updated
- 2021/12/16
Methyl 5-bromonicotinate Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
A substrate used in a microwave-assisted, palladium-catalyzed arylation of acetone as its TMS enol ether.
Application
Methyl 5-bromonicotinate could be used to synthesize Pyridine alkaloids from Rubiaceae with various organometallic reagents by palladium-catalyzed cross-coupling reactions. This compound is a derivative of 5-bromonicotinic acid (BrnicH) which has been widely used in the last decade to obtain MOF materials with unique luminescence, magnetism, catalysis, and adsorption through assembling with lanthanide ions and transition metal ions, such as Cu(II), Co(II), Cd(II), Zn(II), and Pb(II)[1-2].
Synthesis
To an ice-cooled suspension of 5-bromo nicotinic acid (1.6g, 7.9 mmol) in diethyl ether (20ml), a solution of diazomethane in diethyl ether was added dropwise with stirring until the mixture remained yellow. The mixture was stirred for additional 15min (hood!), and the volatile compounds were removed by distillation in vaeuo. Finally, Methyl 5-bromonicotinate was obtained after purification[2].
References
[1] WENJIE LI . Syntheses, crystal structures, and properties of new metal–5-bromonicotinate coordination polymers[J]. Journal of Solid State Chemistry, 2015. DOI:10.1016/j.jssc.2015.01.002.
[2] Bracher, F., Papke, T. Total syntheses and antimicrobial activities of pyridine alkaloids from Rubiaceae. Monatsh Chem 126, 805–809 (1995). https://doi.org/10.1007/BF00807174
Methyl 5-bromonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 5-bromonicotinate manufacturers
- Product
- Kasugamycin Hydrochloride 29681-44-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.91%
- Supply Ability
- 200000
- Release date
- 2024-04-16
- Product
- Methyl 5-bromonicotinate 29681-44-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Ton
- Release date
- 2022-11-02
- Product
- Methyl 5-bromonicotinate 29681-44-5
- Price
- US $10.00-8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2022-09-16