METHYL 2-CHLORONICOTINATE
- Product Name
- METHYL 2-CHLORONICOTINATE
- CAS No.
- 40134-18-7
- Chemical Name
- METHYL 2-CHLORONICOTINATE
- Synonyms
- METHYL 2-CHLOROPYRIDINE-3-CARBOXYLATE;METHYL 2-CHLORONICOT;METHYL-2-CHLONICOTINATE;Methyl 2-chloronicotite;Mehyl 2-Chloronicotinate;METHYL 2-CHLORONICOTINATE;Methyl2-Chloronicotinate>Methyl 2-chloronicotinate 98%;2-CHLORONICOTINIC ACID METHYL ESTER;METHYL 2-CHLORO-3-PYRIDINECARBOXYLATE
- CBNumber
- CB2317331
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 40134-18-7.mol
METHYL 2-CHLORONICOTINATE Property
- Boiling point:
- 150 °C/1 mmHg
- Density
- 1.314 g/mL at 25 °C
- refractive index
- n 20/D 1.537
- Flash point:
- 110 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- pka
- -1.39±0.10(Predicted)
- color
- Colorless
- CAS DataBase Reference
- 40134-18-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2165
- Product name
- Methyl 2-Chloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $19
- Updated
- 2025/07/31
- Product number
- M2165
- Product name
- Methyl 2-Chloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- 454915
- Product name
- Methyl 2-chloronicotinate
- Packaging
- 500mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- M295693
- Product name
- Methyl 2-Chloronicotinate
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- OR3350
- Product name
- Methyl 2-Chloronicotinate
- Purity
- 98%
- Packaging
- 100g
- Price
- $56
- Updated
- 2021/12/16
METHYL 2-CHLORONICOTINATE Chemical Properties,Usage,Production
Description
Methyl 2-chloronicotinate is used in proteomics studies.
Synthesis
67-56-1
2942-59-8
40134-18-7
(1) Preparation of methyl 2-chloronicotinate: 15.0 g (95.2 mmol) of 2-chloronicotinate was dissolved in 150 mL of dichloromethane and 8.37 mL (94.5 mmol) of oxalyl chloride was added slowly and dropwise. Subsequently, N,N-dimethylformamide was added dropwise to the mixture and the reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, 40.1 mL (286 mmol) of triethylamine and 37 mL (914 mmol) of methanol were added dropwise to the reaction mixture under ice-bath cooling conditions and stirring was continued for 30 minutes under ice-bath cooling. The reaction mixture was concentrated under reduced pressure and neutralized by adding aqueous sodium bicarbonate to the residue. The aqueous phase was extracted with ether, the organic phases were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (eluent: ethyl acetate/hexane=1:4) to afford 13.9 g of the target product methyl 2-chloronicotinate as a pale yellow liquid in 86% yield.1H-NMR (CDCl3/TMS, δ ppm): 3.97 (3H, s), 7.33 (1H, dd), 8.17 (1H, dd), 8.53 (1H, dd ).
References
[1] Patent: CN105061399, 2017, B. Location in patent: Paragraph 0010; 0029; 0030
[2] Patent: US2011/287937, 2011, A1. Location in patent: Page/Page column 72-73
[3] Patent: WO2007/71900, 2007, A1. Location in patent: Page/Page column 94
[4] Yakugaku Zasshi, 1952, vol. 72, p. 1336,1338
[5] Chem.Abstr., 1953, p. 4336
METHYL 2-CHLORONICOTINATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 2-CHLORONICOTINATE manufacturers
- Product
- METHYL 2-CHLORONICOTINATE 40134-18-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14