5-Chloropyridine-3-carboxylic acid methyl ester
- Product Name
- 5-Chloropyridine-3-carboxylic acid methyl ester
- CAS No.
- 51269-81-9
- Chemical Name
- 5-Chloropyridine-3-carboxylic acid methyl ester
- Synonyms
- Methyl 5-chloronicotinate;5-Chlor-nicotinsaeure-Methylester;Methyl 5-chloropyridine-3-carboxylate;Methyl 3-chloropyridine-5-carboxylate;5-chloro-3-Pyridinecarboxylic acid methyl ester;5-Chloropyridine-3-carboxylic acid methyl ester;(2S)-2-amino-3-(4-prop-5-enoxyphenyl)propanoicacid;3-Pyridinecarboxylic acid, 5-chloro-, methyl ester
- CBNumber
- CB8967509
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 51269-81-9.mol
5-Chloropyridine-3-carboxylic acid methyl ester Property
- Melting point:
- 88-90 °C
- Boiling point:
- 230.4±20.0 °C(Predicted)
- Density
- 1.294±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 0.91±0.20(Predicted)
- color
- White
- InChI
- InChI=1S/C7H6ClNO2/c1-11-7(10)5-2-6(8)4-9-3-5/h2-4H,1H3
- InChIKey
- TVUWLLCWQGXPSH-UHFFFAOYSA-N
- SMILES
- C1=NC=C(Cl)C=C1C(OC)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M340425
- Product name
- Methyl5-Chloronicotinate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 067068
- Product name
- Methyl 5-chloronicotinate
- Purity
- 98%
- Packaging
- 1g
- Price
- $46
- Updated
- 2021/12/16
- Product number
- CS-0019209
- Product name
- Methyl5-chloronicotinate
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- OR906050
- Product name
- 5-Chloropyridine-3-carboxylicacidmethylester
- Purity
- 98%
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- FC153722
- Product name
- 5-CHLOROPYRIDINE-3-CARBOXYLIC ACID METHYL ESTER
- Packaging
- 500mg
- Price
- $135
- Updated
- 2021/12/16
5-Chloropyridine-3-carboxylic acid methyl ester Chemical Properties,Usage,Production
Synthesis
67-56-1
22620-27-5
51269-81-9
Concentrated sulfuric acid (4 mL) was slowly added to a stirred solution of 5-chloronicotinic acid (5 g, 31.8 mmol) in methanol (40 mL). The reaction mixture was placed in a 75°C oil bath and heated to reflux for 12 hours. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove most of the methanol. The residue was diluted with distilled water (50 mL) and subsequently extracted with ethyl acetate (3 x 30 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate solution (20 mL) and saturated sodium chloride solution (20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to afford methyl 5-chloronicotinate (4.4 g, 80% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 9.08 (d, J=1.6Hz, 1H), 8.73 (d, J=2.4Hz, 1H), 8.28-8.27 (t, J=2.0Hz, 1H), 3.96 (s, 3H). Mass spectrometry (MS) showed a molecular ion peak (M+1) of 172.12.
References
[1] Patent: WO2015/97122, 2015, A1. Location in patent: Page/Page column 100
[2] Patent: US2014/107340, 2014, A1. Location in patent: Paragraph 0123
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 23, p. 9496 - 9508
[4] Chemische Berichte, 1928, vol. 61, p. 2211
[5] Patent: WO2009/6370, 2009, A1. Location in patent: Page/Page column 27-28
5-Chloropyridine-3-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloropyridine-3-carboxylic acid methyl ester manufacturers
- Product
- Methyl 5-chloronicotinate 51269-81-9
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02
- Product
- Methyl 5-chloronicotinate 51269-81-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10
- Product
- 5-Chloropyridine-3-carboxylic acid methyl ester 51269-81-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-17