2-Chloronicotinic acid
- Product Name
- 2-Chloronicotinic acid
- CAS No.
- 2942-59-8
- Chemical Name
- 2-Chloronicotinic acid
- Synonyms
- 2-CHLOROPYRIDINE-3-CARBOXYLIC ACID;CHLORONICOTINIC ACID;2-CHLORO-3-PYRIDINECARBOXYLIC ACID;2CLNA;2-Chloronicoti;AKOS BBS-00004231;2 - chloro niacin;oronicotinic acid;RARECHEM AL BO 0287;TIMTEC-BB SBB004002
- CBNumber
- CB7714896
- Molecular Formula
- C6H4ClNO2
- Formula Weight
- 157.55
- MOL File
- 2942-59-8.mol
2-Chloronicotinic acid Property
- Melting point:
- 176-178 °C (dec.)(lit.)
- Boiling point:
- 316.8±22.0 °C(Predicted)
- Density
- 1.470±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO, Ethyl Acetate (Slightly)
- pka
- 2.07±0.25(Predicted)
- form
- Powder
- color
- White to cream
- BRN
- 119023
- InChI
- InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10)
- InChIKey
- IBRSSZOHCGUTHI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1C(O)=O
- LogP
- 0.988
- CAS DataBase Reference
- 2942-59-8(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Chloronicotinic acid (2942-59-8)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-37/39-26-36
- WGK Germany
- 3
- TSCA
- T
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 150339
- Product name
- 2-Chloropyridine-3-carboxylic acid
- Purity
- 99%
- Packaging
- 10g
- Price
- $49.5
- Updated
- 2024/03/01
- Product number
- PHR2305
- Product name
- Flunixin Related Compound A
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 50MG
- Price
- $534
- Updated
- 2024/03/01
- Product number
- 1274629
- Product name
- Flunixin Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 15mg
- Price
- $596
- Updated
- 2024/03/01
- Product number
- C1108
- Product name
- 2-Chloronicotinic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $21
- Updated
- 2024/03/01
- Product number
- C1108
- Product name
- 2-Chloronicotinic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 250g
- Price
- $99
- Updated
- 2024/03/01
2-Chloronicotinic acid Chemical Properties,Usage,Production
Chemical Properties
white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.
Uses
2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.
Application
2-Chloronicotinic acid is used in the synthesis of the anti-inflammatory and analgesic pralofen. It is an intermediate of the herbicides nicosulfuron and diflufenican. It is also used as pharmaceutical intermediates for the manufacture of mefenamic acid, niflumic acid, etc.
Preparation
Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.
Definition
ChEBI: 2-Chloronicotinic acid is an aromatic carboxylic acid and a member of pyridines.
2-Chloronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloronicotinic acid Suppliers
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View Lastest Price from 2-Chloronicotinic acid manufacturers
- Product
- 2-Chloronicotinic acid 2942-59-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 2-Chloronicotinic acid 2942-59-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 5000kg
- Release date
- 2023-10-10
- Product
- 2-Chloronicotinic acid 2942-59-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0% min
- Supply Ability
- 10tons/month
- Release date
- 2023-06-09