2-Chloro-3-fluoropyridine
Application- Product Name
- 2-Chloro-3-fluoropyridine
- CAS No.
- 17282-04-1
- Chemical Name
- 2-Chloro-3-fluoropyridine
- Synonyms
- 2-Chloro-3-flu;2-Chloro-3-fluoropyr;2-CHLORO-3-FLUOROPYRIDINE;2-chloro-3-fluoro picoline;Pyridine, 2-chloro-3-fluoro-;2-Chloro-3-fluoropyridine>2-Chloro-3-fluoropyridine, 95%;2-bromo-4-methyl-6-nitropyridine;2-Chloro-3-fluoropyridine ISO 9001：2015 REACH
- CBNumber
- CB1719703
- Molecular Formula
- C5H3ClFN
- Formula Weight
- 131.54
- MOL File
- 17282-04-1.mol
2-Chloro-3-fluoropyridine Property
- Boiling point:
- 80 °C/80 mmHg (lit.)
- Density
- 1.323 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.509(lit.)
- Flash point:
- 147 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- -0.05±0.10(Predicted)
- color
- Colorless to Almost colorless
- BRN
- 1363435
- InChI
- InChI=1S/C5H3ClFN/c6-5-4(7)2-1-3-8-5/h1-3H
- InChIKey
- SVAZIMBLBHOVIR-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1F
- CAS DataBase Reference
- 17282-04-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-41-36/37/38-37/38-23/24/25
- Safety Statements
- 26-36-45-36/37/39
- RIDADR
- 2810
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 636576
- Product name
- 2-Chloro-3-fluoropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $62.8
- Updated
- 2023/06/20
- Product number
- 636576
- Product name
- 2-Chloro-3-fluoropyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $262
- Updated
- 2023/06/20
- Product number
- C2447
- Product name
- 2-Chloro-3-fluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- C2447
- Product name
- 2-Chloro-3-fluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- C382338
- Product name
- 2-Chloro-3-Fluoropyridine
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
2-Chloro-3-fluoropyridine Chemical Properties,Usage,Production
Application
2-Chloro-3-fluoropyridine is a pyridine derivative that can be used as a pharmaceutical intermediate.
Chemical Properties
Colorless to light yellow liquid
Synthesis
372-47-4
17282-04-1
General procedure for the synthesis of 2-chloro-3-fluoropyridine from 3-fluoropyridine: n-butyllithium (2.5 M hexane solution, 230 ml, 0.57 mol) was added to a solution of 1,4-diazabicyclo[2.2.2]octane (63.8 g, 0.57 mol) in ether (2.5 L) that had been pre-removed from water by azeotropic boiling, at -20 to -30 °C. After stirring for 1 hour, the temperature was adjusted to -65°C. A solution of 3-fluoropyridine (50.0 g, 0.52 mol) in ether (250 ml) was added dropwise over 10 minutes and the mixture was stirred for another 1 hour. Then an ether (350 ml) solution of hexachloroethane (136.5 g, 0.58 mol) was added dropwise over 15 minutes, keeping the temperature below -60°C, and the mixture was stirred for 2 hours. The reaction was quenched by addition of saturated aqueous NH4Cl solution (250 ml), warmed to ambient temperature and separated. The aqueous phase was extracted with ether (2 x 250 ml) and the combined organic phases were washed with saturated aqueous NH4Cl solution (250 ml), dried over anhydrous MgSO4 and concentrated in vacuum. The residue was diluted with isohexane (150 ml), washed with 2N hydrochloric acid (3 x 100 ml) and then with 37% hydrochloric acid (3 x 50 ml). The acid wash was then extracted with isohexane (3 x 100 ml), alkalized to pH 14 by careful addition of 4N aqueous NaOH (500 ml) and re-extracted with CH2Cl2 (3 x 150 ml). The organic fraction was dried over anhydrous MgSO4 and concentrated in vacuum. The residue was purified by distillation (boiling point 74-82 °C, 1 atm) to give 2-chloro-3-fluoropyridine as a straw-colored oil (42.6 g, 63%).
References
[1] Patent: WO2003/99816, 2003, A1. Location in patent: Page 42-43
[2] Patent: WO2003/99817, 2003, A1. Location in patent: Page 35
[3] Angewandte Chemie - International Edition, 2018, vol. 57, # 29, p. 9103 - 9107
[4] Angew. Chem., 2018, vol. 130, p. 9241 - 9245,5
[5] Journal of Medicinal Chemistry, 2004, vol. 47, # 15, p. 3853 - 3864
2-Chloro-3-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-fluoropyridine manufacturers
- Product
- 2-Chloro-3-fluoropyridine 17282-04-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2-Chloro-3-fluoropyridine 17282-04-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 2-Chloro-3-fluoropyridine 17282-04-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2025-03-14