2-Chloro-3-pyridinamine
- Product Name
- 2-Chloro-3-pyridinamine
- CAS No.
- 6298-19-7
- Chemical Name
- 2-Chloro-3-pyridinamine
- Synonyms
- 2-CHLOROPYRIDIN-3-AMINE;2-CHLORO-3-AMINOPYRIDINE;2-CHLORO-PYRIDIN-3-YLAMINE;3-AMINO-2-CHLOROPYRIDINE;Nsc 45407;AKOS MSC-0729;oro-3-pyridyL;TIMTEC-BB SBB004233;2-Chloro-3-pyridinam;3-AMINOCHLOROPYRIDINE
- CBNumber
- CB3673072
- Molecular Formula
- C5H5ClN2
- Formula Weight
- 128.56
- MOL File
- 6298-19-7.mol
2-Chloro-3-pyridinamine Property
- Melting point:
- 76-78 °C (lit.)
- Boiling point:
- 130-134 °C (12.7517 mmHg)
- Density
- 130
- refractive index
- 1.5110 (estimate)
- Flash point:
- 185 °C
- storage temp.
- 2-8°C
- solubility
- 30g/l
- pka
- 2.42±0.10(Predicted)
- form
- Crystalline Powder, Crystals, and/or Chunks
- color
- Off-white to yellow to pink
- PH
- 7 (30g/l, H2O, 20℃)
- Water Solubility
- Soluble in methanol and water. (30 g/L).
- BRN
- 109814
- InChI
- 1S/C5H5ClN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H2
- InChIKey
- MEQBJJUWDCYIAB-UHFFFAOYSA-N
- SMILES
- Nc1cccnc1Cl
- CAS DataBase Reference
- 6298-19-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 3-Amino-2-chloropyridine(6298-19-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A46900
- Product name
- 3-Amino-2-chloropyridine
- Purity
- 98%
- Packaging
- 10g
- Price
- $47.98
- Updated
- 2025/07/31
- Product number
- A46900
- Product name
- 3-Amino-2-chloropyridine
- Purity
- 98%
- Packaging
- 50g
- Price
- $88.47
- Updated
- 2025/07/31
- Product number
- A0836
- Product name
- 3-Amino-2-chloropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- A604085
- Product name
- 3-Amino-2-chloropyridine
- Packaging
- 250g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 011152
- Product name
- 3-Amino-2-chloropyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $11
- Updated
- 2021/12/16
2-Chloro-3-pyridinamine Chemical Properties,Usage,Production
Chemical Properties
off-white to yellow to pink crystalline powder,
Uses
It is an intermediate of medicine and agricultural chemicals. It is involved in the Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds.
Synthesis
Dissolve 188g (2mol) of 3-aminopyridine in 10% hydrochloric acid: 900g (10%, 2.46mol), completely dissolved and mixed, the volume ratio of the solution to dichloromethane: 400g, sodium hypochlorite solution: 800g (10%, 1.07mol) as a preset unit time volume ratio, and then according to the unit time volume ratio at room temperature (the specific temperature range of 10 ?? -30 ?? the same below) will be pumped into the first stage extraction centrifuge for extraction centrifugation; after that, separate the organic phase and the organic phase continuously. Then, according to the unit time volume ratio at room temperature (the specific temperature range of room temperature is 10 ?? -30 ?? the same below) will be three separate and at the same time continuously pumped into the first stage of the extraction centrifuge extraction centrifugation; after that, the separation of organic phase and aqueous phase, and retain the organic phase, the aqueous phase, industrial hydrochloric acid: 59g (content of 31%, 0.5mol), dichloromethane: 200g, and sodium hypochlorite solution: 400g (10%, 0.54mol) four of the volume ratio, the content of the organic phase: 500g (content of 10 percent, 1.07mol), the volume ratio of the organic phase: 800g (content of 10 percent, 1.07mol) (content 10%, 0.54 mol) as a preset unit time volume ratio, and then in accordance with the unit time volume ratio at room temperature, the four were separately and simultaneously pumped continuously into the second stage of the extraction centrifuge extraction centrifuge; after that, the separation of organic and aqueous phases, and retaining the organic phase, and put the aqueous phase into the next stage of the extraction centrifuge; the subsequent amount of hydrochloric acid, methylene chloride, and sodium hypochlorite solution used in each stage of extraction centrifuge volume The amount of hydrochloric acid, dichloromethane and sodium hypochlorite solution used in each subsequent stage of extraction centrifuge was reduced by half, a total of five stages of continuous extraction reaction (each stage of extraction centrifugal reaction time was 3h), after which the organic phase was combined as 3-amino-2-chloropyridine solution; a total of 962g of solution was obtained, which was analyzed by liquid chromatography with external standard method, and the content of the external standard method was calculated to be 24.4%, the weight of the 3-amino-2-chloropyridine was calculated to be 234.5g, and the molar yield of 3-amino-2-chloropyridine was 91.3 The molar yield of 3-amino-2-chloropyridine was 91.3% (as 3-aminopyridine), purity was 98.4%.
2-Chloro-3-pyridinamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-pyridinamine manufacturers
- Product
- 2-Chloro-3-pyridinamine 6298-19-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-11
- Product
- 2-Chlorpyridin-3-amin 6298-19-7
- Price
- US $6.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-24
- Product
- 2-Chlorpyridin-3-amin 6298-19-7
- Price
- US $100.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-13