5-Bromo-2-chloro-3-nitropyridine

Product Name: 5-Bromo-2-chloro-3-nitropyridine
CAS No.: 67443-38-3
Chemical Name: 5-Bromo-2-chloro-3-nitropyridine
Synonyms: 5-Bromo-2-ch;RARECHEM AL BO 2390;IFLAB-BB F1957-0001;5-BROMO-2-PICOLINIC ACID;Medetomidine Impurity 65;5-BROMO-2-CARBOXYPYRIDINE;5-Bromo-2-chloro-3-nitrop...;2-CHLORO-5-BROMO-3-NITROPYRIDINE;2-Chloro-3-nitro-5-bromopyridine;5-BROMO-2-CHLORO-3-NITROPYRIDINE
CBNumber: CB8854096
Molecular Formula: C5H2BrClN2O2
Formula Weight: 237.44
MOL File: 67443-38-3.mol

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5-Bromo-2-chloro-3-nitropyridine Property

Melting point:: 65-70 °C
Boiling point:: 285.4±35.0 °C(Predicted)
Density: 1.936±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Methanol
pka: -4.99±0.10(Predicted)
form: Crystalline Powder
color: Yellow
InChI: InChI=1S/C5H2BrClN2O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H
InChIKey: WWQQPSDIIVXFOX-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Br)C=C1[N+]([O-])=O
CAS DataBase Reference: 67443-38-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi,T
Risk Statements: 36/37/38-21/22-41-37/38-25-22
Safety Statements: 37/39-26-45-36
RIDADR: 2811
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT, IRRITANT-HARMFUL
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 734756
Product name: 5-Bromo-2-chloro-3-nitropyridine
Purity: 97%
Packaging: 5g
Price: $58.4
Updated: 2023/06/20

TCI Chemical

Product number: B3963
Product name: 5-Bromo-2-chloro-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: B3963
Product name: 5-Bromo-2-chloro-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $140
Updated: 2025/07/31

TRC

Product number: B682370
Product name: 5-Bromo-2-chloro-3-nitropyridine
Packaging: 5g
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-D0810
Product name: 5-bromo-2-chloro-3-nitropyridine
Purity: 99.88%
Packaging: 100g
Price: $60
Updated: 2021/12/16

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5-Bromo-2-chloro-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

5-Bromo-2-chloro-3-nitropyridine is used as pharmaceutical intermediate.

Synthesis

6945-68-2

67443-38-3

The general procedure for the synthesis of 2-chloro-3-nitro-5-bromopyridine from 2-amino-3-nitro-5-bromopyridine was as follows: 2-amino-5-bromo-3-nitropyridine (21.8 g, 0.1 mol) was ground in a mortar and pestle to a fine powder, which was subsequently suspended in 6 M hydrochloric acid (250 ml). The mixture was cooled to 0 °C and solid NaNO2 (8.3 g, 0.12 mol) was slowly added while keeping the internal temperature below 5 °C (about 45 min). After addition, stirring was continued at 0 °C for 1 hour. To the resulting suspension was added a solution of freshly prepared copper(I) chloride (12.9 g, 0.13 mol) dissolved in degassed 38% hydrochloric acid, and the reaction mass was gradually warmed up to room temperature over 90 min, and then subsequently heated up to 70°C to complete the decomposition of the diazonium salt. The reaction mixture was cooled, diluted with water (750 ml), passed through air for 30 min, and the pH was subsequently adjusted by the addition of 0.88 ammonia to about 9. The blue mixture was mixed with ether (600 ml) and shaken, and the insoluble solids were removed by filtration. The organic layer was washed sequentially with 5% ammonia, water, and brine and dried with anhydrous sodium sulfate. After filtration, the solution was pre-adsorbed onto silica and purified by fast chromatography using a gradient elution of isohexane with 5% to 20% ethyl acetate to afford 5-bromo-2-chloro-3-nitropyridine as a light yellow solid (13.1 g, 55% yield) and to recover the starting material (6.4 g). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.36 (1H, d, J=1Hz, H-6), 8.69 (1H, d, J=1Hz, H-4).

References

[1] Patent: WO2007/129044, 2007, A1. Location in patent: Page/Page column 77
[2] Patent: EP1214319, 2003, B1. Location in patent: Page/Page column 13
[3] Journal of Heterocyclic Chemistry, 2003, vol. 40, # 2, p. 261 - 268
[4] Journal of the Chemical Society, 1952, p. 2042,2044
[5] Journal of the Chemical Society, 1952, p. 2042,2044

5-Bromo-2-chloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride Sodium nitrite Phosphorus pentachloride 2-Amino-5-bromopyridine Nitric acid Sulfuric acid

Preparation Products

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5-Bromo-2-chloro-3-nitropyridine Suppliers

Americas 1 Belgium 1 Canada 2 China 368 Europe 3 France 2 Germany 5 India 29 Japan 1 South Korea 1 The Netherlands 1 United Kingdom 13 United States 52 Global 479

Cool Pharm, Ltd

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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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future industrial shanghai co., ltd

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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from 5-Bromo-2-chloro-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromo-2-chloro-3-nitropyridine 67443-38-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Bromo-2-chloro-3-nitropyridine 67443-38-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Henan Fengda Chemical Co., Ltd

Product: 5-Bromo-2-chloro-3-nitropyridine 67443-38-3
Price: US $6.00-0.20/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-03

67443-38-3, 5-Bromo-2-chloro-3-nitropyridineRelated Search:

1-Hexadecylpyridinium bromide Clopidol 2-Chloro-3-nitropyridine 3-Amino-5-bromo-2-chloropyridine 2,3,5,6-Tetrachloropyridine 4-Chloro-3-nitropyridine 4-Nitrophenyl chloroformate 2-Chloro-3-fluoropyridine 3-AMINO-2-CHLORO-5-PICOLINE 2-Chloro-5-fluoronicotinonitrile 2-Chloro-3-pyridinamine 4-Bromo-2-chloro-3-iodopyridine 3-Amino-2-chloro-4-methylpyridine 5-Amino-2-chloro-3-picoline 2-CHLORO-3-FLUORO-4-IODOPYRIDINE 6-Bromo-2-chloro-3-iodopyridine 2-Chloro-3-methyl-5-nitropyridine 2-Chloro-3-methyl-5-bromopyridine

RARECHEM AL BO 2390

2-Chloro-3-nitro-5-bromopyridine

2-CHLORO-5-BROMO-3-NITROPYRIDINE

5-BROMO-2-CHLORO-3-NITROPYRIDINE 98%

5-Bromo-2-chloro-3-nitropyridine,98%

5-Bromo-2-chloro-3-nitrop...

5-BroMo-2-chloro-3-nitropyridine, 98% 1GR

5-BroMo-2-chloro-3-nitropyridine, 98% 5GR

2 - chloro - 3 - nitro - 5 - broMide pyridine

Pyridine, 5-bromo-2-chloro-3-nitro-

2-chloro -3-nitro -5-pyridyl broMide

2-PYRIDINECARBOXYLIC ACID, 5-BROMO-

5-Bromo-2-ch

5-BROMO-2-CARBOXYPYRIDINE

5-BROMO-2-CHLORO-3-NITROPYRIDINE

5-BROMO-2-PICOLINIC ACID

IFLAB-BB F1957-0001

5-Bromo-2-chloro-3-nitropyridine &gt

5-Bromo-2-chloro-3-nitropyridine ISO 9001：2015 REACH

2-Cholor-5-bromo-3-nitro pyridine

Medetomidine Impurity 65

67443-38-3

30776-11-1

C5H2BrCl2N2O2

C5H2BrClN2O2

Heterocyclic Compounds

Boronic Acid

Pyridine Series

blocks

Bromides

Pyridine

pyridines

compounds of pyridine

Aromatics

Heterocycles

Miscellaneous Reagents

bc0001