4-Chloro-3-nitropyridine
- Product Name
- 4-Chloro-3-nitropyridine
- CAS No.
- 13091-23-1
- Chemical Name
- 4-Chloro-3-nitropyridine
- Synonyms
- 4-Chlor-3-nitro-pyridin;3-nitro-4-chloropyridine;4-CHLORO-3-NITROPYRIDINE;Pyridine, 4-chloro-3-nitro-;4-CHLORO-3-NITROPYRIDINE 98%;4-chloro-3-nitropyridine, 97%,;4-Chloro-3-nitropyridine, tech.;4-
Chloro- 3- nitropyridine;4-Chloro-3-nitropyridine ISO 9001：2015 REACH;4-CHLORO-3-NITROPYRIDINE 4-CHLORO-3-NITROPYRIDINE - CBNumber
- CB0471099
- Molecular Formula
- C5H3ClN2O2
- Formula Weight
- 158.54
- MOL File
- 13091-23-1.mol
4-Chloro-3-nitropyridine Property
- Melting point:
- 35-50 °C
- Boiling point:
- 95 °C(Press: 5 Torr)
- Density
- 1.489±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 0.56±0.10(Predicted)
- form
- Crystalline Powder
- color
- Pale yellow
- Water Solubility
- Insoluble in water.
- InChI
- InChI=1S/C5H3ClN2O2/c6-4-1-2-7-3-5(4)8(9)10/h1-3H
- InChIKey
- JOTRPRKONYTVBV-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(Cl)=C1[N+]([O-])=O
- CAS DataBase Reference
- 13091-23-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-41-22
- Safety Statements
- 26-36/37/39-36/39-37/38-36
- RIDADR
- UN 2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, KEEP COLD
- PackingGroup
- III
- HS Code
- 29333990
N-Bromosuccinimide Price
- Product number
- 674079
- Product name
- 4-Chloro-3-nitropyridine
- Purity
- 90%
- Packaging
- 5g
- Price
- $61.14
- Updated
- 2025/07/31
- Product number
- C5029-17
- Product name
- 4-Chloro-3-nitropyridine
- Packaging
- 1g
- Price
- $403
- Updated
- 2021/12/16
- Product number
- 4907
- Product name
- 4-Chloro-3-nitropyridine
- Packaging
- 1g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- FC00159
- Product name
- 4-Chloro-3-nitropyridine
- Packaging
- 50g
- Price
- $675
- Updated
- 2021/12/16
- Product number
- 4H54-5-19
- Product name
- 4-Chloro-3-nitropyridine
- Packaging
- 25g
- Price
- $238
- Updated
- 2021/12/16
4-Chloro-3-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Snuff color to brown powder
Uses
4-Chloro-3-nitropyridine (cas# 13091-23-1) is a compound useful in organic synthesis.
Synthesis
5435-54-1
13091-23-1
Example 1: General procedure for the synthesis of 4-chloro-3-nitropyridine from 4-hydroxy-3-nitropyridine Step 1: Synthesis of 4-chloro-3-nitropyridine To a suspension of 3-nitro-4-pyridinol (20 g, 143 mmol) in toluene (300 mL) was slowly added phosphorus trichloride (65.7 g, 429 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux (110 °C) and held for 16 hours. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by rotary evaporator under reduced pressure. The residue was carefully poured into ice water and the pH was adjusted with potassium carbonate (K2CO3) to 10. The aqueous phase was extracted with ethyl acetate and the organic phase was washed sequentially twice with water and once with brine. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a brown oil, which solidified on standing to the target product 4-chloro-3-nitropyridine (22.5 g, 99% yield). Mass spectrum (electrospray positive ion mode) m/e 159 [M+H]+.
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 2 - 5
[2] Patent: WO2005/37197, 2005, A2. Location in patent: Page/Page column 80; 83
[3] Patent: WO2005/37198, 2005, A2. Location in patent: Page/Page column 20
[4] Patent: WO2005/51304, 2005, A2. Location in patent: Page/Page column 70
[5] Patent: WO2005/51304, 2005, A2. Location in patent: Page/Page column 70
4-Chloro-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-3-nitropyridine manufacturers
- Product
- 4-Chloro-3-nitropyridine 13091-23-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2025-04-21
- Product
- 4-Chloro-3-nitropyridine 13091-23-1
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-25
- Product
- 4-Chloro-3-nitropyridine 13091-23-1
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-21