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2-Nitrochlorobenzene

Product Name
2-Nitrochlorobenzene
CAS No.
88-73-3
Chemical Name
2-Nitrochlorobenzene
Synonyms
1-CHLORO-2-NITROBENZENE;ONCB;2-CHLORONITROBENZENE;O-NITROCHLOROBENZENE;ORTHO-CHLORONITROBENZENE;2-cnb;lenvaint-F;oronitrobenzene;2-Chlornitrobenzol;o-Chloronitrobenzen
CBNumber
CB3767980
Molecular Formula
C6H4ClNO2
Formula Weight
157.55
MOL File
88-73-3.mol
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2-Nitrochlorobenzene Property

Melting point:
31-33 °C (lit.)
Boiling point:
246 °C (lit.)
Density 
1.348 g/mL at 25 °C (lit.)
vapor density 
5.4 (vs air)
vapor pressure 
0.04 mm Hg ( 25 °C)
refractive index 
1.5520 (estimate)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
alcohol: soluble
form 
Fused Crystalline Mass
color 
Yellow
PH
6 (0.4g/l, H2O, 20℃)
explosive limit
1.15-13.1%(V)
Water Solubility 
0.43 g/L (20 ºC)
Merck 
14,2151
BRN 
509273
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, strong bases, alkali metals.
InChIKey
BFCFYVKQTRLZHA-UHFFFAOYSA-N
CAS DataBase Reference
88-73-3(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-chloro-2-nitro-(88-73-3)
IARC
2B (Vol. 65, 123) 2020
EPA Substance Registry System
o-Chloronitrobenzene (88-73-3)
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Safety

Hazard Codes 
T
Risk Statements 
22-24-52-53-52/53
Safety Statements 
36/37/39-45-60-38-28A
RIDADR 
UN 1578 6.1/PG 2
WGK Germany 
2
RTECS 
CZ0875000
Autoignition Temperature
500 °F
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29049085
Hazardous Substances Data
88-73-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
185760
Product name
1-Chloro-2-nitrobenzene
Purity
99%
Packaging
1kg
Price
$31.96
Updated
2024/03/01
Sigma-Aldrich
Product number
185760
Product name
1-Chloro-2-nitrobenzene
Purity
99%
Packaging
250g
Price
$49.2
Updated
2024/03/01
TCI Chemical
Product number
C0220
Product name
2-Chloronitrobenzene
Purity
>99.0%(GC)
Packaging
25g
Price
$16
Updated
2023/06/20
TCI Chemical
Product number
C0220
Product name
2-Chloronitrobenzene
Purity
>99.0%(GC)
Packaging
500g
Price
$60
Updated
2023/06/20
Alfa Aesar
Product number
A15403
Product name
1-Chloro-2-nitrobenzene, 99%
Packaging
250g
Price
$25.4
Updated
2023/06/20
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2-Nitrochlorobenzene Chemical Properties,Usage,Production

Chemical Properties

yellow solid with a characteristic odour

Uses

Chemical intermediate in manufacture of dyes, picric acid, lumber preservatives, and diaminophenol hydrochloride (a photographic developer)

Uses

1-Chloro-2-nitrobenzene was used in the synthesis of 1-hydroxybenzotriazole derivatives. It is important as a precursor to other compounds due to the two reactive sites present on the molecule.

Uses

Intermediate, especially for dyes.

Production Methods

Nitration of chlorobenzene with mixed acid (30/56/14) typically gives an isomer mix in 98 % yield consisting of 34 – 36 % 2-Nitrochlorobenzene, 63 – 65 % 4- chloronitrobenzene, and only ca. 1 % 3- chloronitrobenzene. The ortho – para ratio of about 0.55 is in sharp contrast to the 1.6 obtained with nitrotoluene isomers. As with the nitration of toluene, much work has been done on isomer control so that the producer might have some flexibility towards the balance of isomer demand. Although no major change in ratio has been achieved, the situation is better for nitrochlorobenzene than nitrotoluenes, because the favored isomer is in much greater demand. In further contrast to the nitration of toluene, the nitration of chlorobenzene in the presence of phosphoric acid decreases the proportion of 4-Nitrochlorobenzene, and the use of phosphoric acid in the presence of a transition-metal catalyst is said to increase the ortho – para ratio to ca. 0.8.

Definition

ChEBI: 1-chloro-2-nitrobenzene is a C-nitro compound that is nitrobenzene in which one of the ortho- hydrogens has been replaced by chlorine. It is a C-nitro compound and a member of monochlorobenzenes.

General Description

Yellow crystals with an aromatic odor. Sinks in water.

Air & Water Reactions

2-Nitrochlorobenzene may be sensitive to prolonged exposure to air and light. Insoluble in water.

Reactivity Profile

O-NITROCHLOROBENZENE is incompatible with strong bases and strong oxidizing agents. 2-Nitrochlorobenzene will react with ammonia.

Hazard

Toxic by inhalation and ingestion. Combustible. Questionable carcinogen.

Health Hazard

INHALATION: Headache, languour, anemia. Irritation of nose and throat, cyanosis, shallow respiration, convulsions, and coma. EYES: Irritation. SKIN: Irritation. INGESTION: Forms methemoglobin giving rise to cyanosis and blood changes.

Flammability and Explosibility

Not classified

Safety Profile

Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Poison by ingestion, skin contact, and probably inhalation. Combustible when exposed to heat or flame. To fight fire, use water, foam. Potentially explosive reaction with ammonia at 160℃/30 bar. When heated to decomposition it emits toxic fumes of Cl-, NOx, and phosgene. See also other chloronitrobenzene entries and NITRO COMPOUNDS of AROMATIC HYDROCARBONS.

Purification Methods

Crystallise it from EtOH, MeOH or pentane (charcoal). [Beilstein 5 IV 721.]

2-Nitrochlorobenzene Preparation Products And Raw materials

Raw materials

4-Chloronitrobenzene 2-Nitroaniline Chlorobenzene Copper(I) chloride Hydrochloric acid Nitric acid Dimethyl sulfoxide Sodium hydroxide POTASSIUM NITRITE 1-Chloro-3-nitrobenzene Sulfuric acid

Preparation Products

2-Fluorophenol 4-Chloro-3-nitrobenzenesulfonyl chloride 2-Nitroanisole o-Anisidine N-Methyl-1,2-benzenediamine dihydrochloride Aniline-2-sulfonic acid 4-Chloronitrobenzene 2-Mercaptobenzothiazole 2-Chloro-6-nitrotoluene Guaiacol FAST ORANGE GR SALT 2-Nitrophenol 2-Nitrodiphenylamine 3-Amino-4-hydroxybenzenesulphonamide N-METHYL-2-NITROANILINE Bis(2-nitrophenyl) disulfide o-Phenetidine 2-chlorobenzenediazonium 2-Nitroaniline Pigment Yellow 12 2-Fluoroaniline o-Toluidine Disperse Yellow Se-Fl 2-(4-METHYLPHENYL)-BENZOTHIAZOLE ANILAZINE 2-Aminophenol 2-Chloroaniline 2-CHLOROANILINE HYDROCHLORIDE 2-Mercaptobenzimidazole Domperidone 2-Aminobenzenethiol 1-Fluoro-2-nitrobenzene 2,4-Dinitrochlorobenzene o-Phenylenediamine o-chlorobenzenediazonium chloride, compound with zinc chloride
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2-Nitrochlorobenzene Suppliers

China 11 Global 11
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
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Fuxin Pharmaceutical
Tel
+86-021-021-50872116 +8613122107989
Email
contact@fuxinpharm.com
Country
China
ProdList
10032
Advantage
58
Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd
Tel
18072846723; 18072846723
Email
caigou1@witofly.com
Country
China
ProdList
3000
Advantage
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Hubei Zhonglong Kangsheng Fine Chemical Co., Ltd.
Tel
18171205315
Email
1213219329@qq.com
Country
China
ProdList
5041
Advantage
58
Tel
13810281473
Email
115843001name@qq.com
Country
CHINA
ProdList
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Tel
4008-099-669
Email
23419001name@qq.com
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CHINA
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Tel
58896805
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7993601name@qq.com
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Tel
13051508530
Email
114458501name@qq.com
Country
CHINA
ProdList
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