4-Nitrophenyl chloroformate

Product Name: 4-Nitrophenyl chloroformate
CAS No.: 7693-46-1
Chemical Name: 4-Nitrophenyl chloroformate
Synonyms: 4-NITROPHENYL CARBONOCHLORIDATE;P-NITROPHENYL CHLOROFORMATE;PNPCF;Nitrophenyl chloroforMate;4-Nitrophenyl chloridocarbonate;4-NITROPHENYL CHLOROCARBONATE;PARA-NITROPHENYL CHLOROFORMATE;CHLOROFORMIC ACID P-NITROPHENYL ESTER;CARBONOCHLORIDIC ACID, 4-NITROPHENYL ESTER;p-Nitrophenyl c
CBNumber: CB7348509
Molecular Formula: C7H4ClNO4
Formula Weight: 201.56
MOL File: 7693-46-1.mol

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4-Nitrophenyl chloroformate Property

Melting point:: 77-79 °C(lit.)
Boiling point:: 159-162 °C19 mm Hg(lit.)
Density: 1.5719 (rough estimate)
refractive index: 1.6000 (estimate)
Flash point:: >110°C
storage temp.: 2-8°C
solubility: Soluble in acetone, chloroform, acetone, toluene and benzene.
form: isopropanol suspension
color: White to yellow-beige
Water Solubility: decomposes
Sensitive: Lachrymatory
BRN: 518127
Stability:: Stable. Incompatible with strong bases, acids. Combustible.
Major Application: peptide synthesis
InChI: 1S/C7H4ClNO4/c8-7(10)13-6-3-1-5(2-4-6)9(11)12/h1-4H
InChIKey: NXLNNXIXOYSCMB-UHFFFAOYSA-N
SMILES: [O-][N+](=O)c1ccc(OC(Cl)=O)cc1
CAS DataBase Reference: 7693-46-1(CAS DataBase Reference)
NIST Chemistry Reference: Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1)
EPA Substance Registry System: Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1)

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Safety

Hazard Codes: C,T,Xi,F
Risk Statements: 34-36/37-23/24/25-41-36/37/38-11-67-36
Safety Statements: 26-36/37/39-45-38-28A-36-16-27
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
F: 19-21
Hazard Note: Toxic/Corrosive/Lachrymator
TSCA: TSCA listed
HazardClass: 8
PackingGroup: II
HS Code: 29159020
Storage Class: 8A - Combustible corrosive hazardous materials
Hazard Classifications: Eye Dam. 1
Skin Corr. 1B
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 160210
Product name: 4-Nitrophenyl chloroformate
Purity: 96%
Packaging: 5g
Price: $82.8
Updated: 2026/03/19

Sigma-Aldrich

Product number: 160210
Product name: 4-Nitrophenyl chloroformate
Purity: 96%
Packaging: 25g
Price: $250
Updated: 2026/03/19

TCI Chemical

Product number: C1400
Product name: 4-Nitrophenyl Chloroformate
Purity: >98.0%(T)
Packaging: 25g
Price: $99
Updated: 2026/03/19

TCI Chemical

Product number: C1400
Product name: 4-Nitrophenyl Chloroformate
Purity: >98.0%(T)
Packaging: 250g
Price: $614
Updated: 2026/03/19

Sigma-Aldrich

Product number: 160210
Product name: 4-Nitrophenyl chloroformate
Purity: 96%
Packaging: 100g
Price: $580
Updated: 2026/03/19

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4-Nitrophenyl chloroformate Chemical Properties,Usage,Production

Chemical Properties

Cream solid

Uses

4-Nitrophenyl chloroformate can be used:

As a reagent for the activation of amines, alcohols and thiols.
In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).
In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.
In the preparation of poly(oxyethylene) modified dextrans.
To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.

Uses

4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane. It is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.

Application

4-Nitrophenyl chloroformate is used as:A coupling agent to link the drug molecule with the polyrotaxane carrier molecule.As an activated ester reagent that enables the covalent coupling of a peptide onto a macromer, such as oligo(poly(ethylene glycol) fumarate) (OPF).

Description

4-Nitrophenyl chloroformate, also known as p-nitrophenyl chloroformate, is a coupling agent used in the synthesis of ureas, carbamates, and carbonates. It is also used as a building block in solid-phase peptide synthesis (SPPS) to obtain altered side chain functionalities in peptides.

reaction suitability

reaction type: Carbonylations

4-Nitrophenyl chloroformate Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Nitrophenyl chloroformate Suppliers

Americas 1 Belgium 3 Canada 1 China 410 China Hong Kong 1 Czech Republic 4 Europe 5 Germany 6 India 33 Japan 6 Slovakia 1 South Korea 2 Switzerland 2 Ukraine 2 United Kingdom 17 United States 52 Global 546

Jia Xing Isenchem Co.,Ltd

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Alfa Aesar

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View Lastest Price from 4-Nitrophenyl chloroformate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Nitrophenyl chloroformate 7693-46-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Nitrophenyl chloroformate 7693-46-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-19

Henan Fengda Chemical Co., Ltd

Product: 4-Nitrophenyl chloroformate 7693-46-1
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

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7693-46-1

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231-706-9

C8H4O4NI

C7H4Cl1N1O4

ClCO2C6H4NO2

Coupling

Synthetic Reagents

Protection & Derivatization Reagents (for Synthesis)

Active Esters/Additives

Pharmaceutical intermediates

Protection & Derivatization Reagents (for Synthesis)

Synthetic Organic Chemistry