Description Referrence
ChemicalBook > CAS DataBase List > 4-Hydroxyphenylacetic acid

4-Hydroxyphenylacetic acid

Description Referrence
Product Name
4-Hydroxyphenylacetic acid
CAS No.
156-38-7
Chemical Name
4-Hydroxyphenylacetic acid
Synonyms
PHPA;NSC 27460;AKOS 236-100;RARECHEM AL BO 0188;Atenolol Impurity K;4-carboxymethylphenol;4-Hydroxyphenylacetic;Arbidol Impurity F HCl;Hydroxyphenylacetic aci;P-HYDROPHENYLACETIC ACID
CBNumber
CB6314323
Molecular Formula
C8H8O3
Formula Weight
152.15
MOL File
156-38-7.mol
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4-Hydroxyphenylacetic acid Property

Melting point:
148-151 °C(lit.)
Boiling point:
234.6°C (rough estimate)
Density 
1.2143 (rough estimate)
refractive index 
1.4945 (estimate)
storage temp. 
Store below +30°C.
solubility 
50g/l
pka
4.50±0.10(Predicted)
form 
Crystalline Powder
color 
White to cream or light tan
PH
2.0-2.4 (30g/l, H2O, 20℃)
Water Solubility 
Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
BRN 
1448766
InChIKey
XQXPVVBIMDBYFF-UHFFFAOYSA-N
CAS DataBase Reference
156-38-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, 4-hydroxy-(156-38-7)
EPA Substance Registry System
Benzeneacetic acid, 4-hydroxy- (156-38-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
RTECS 
AI2680000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29182990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H50004
Product name
4-Hydroxyphenylacetic acid
Purity
98%
Packaging
5g
Price
$21.3
Updated
2020/08/18
Sigma-Aldrich
Product number
H50004
Product name
4-Hydroxyphenylacetic acid
Purity
98%
Packaging
25g
Price
$40.4
Updated
2020/08/18
TCI Chemical
Product number
H0290
Product name
4-Hydroxyphenylacetic Acid
Purity
>99.0%(GC)(T)
Packaging
25g
Price
$18
Updated
2020/06/24
TCI Chemical
Product number
H0290
Product name
4-Hydroxyphenylacetic Acid
Purity
>99.0%(GC)(T)
Packaging
100g
Price
$47
Updated
2020/06/24
Alfa Aesar
Product number
A15018
Product name
4-Hydroxyphenylacetic acid, 99%
Packaging
25g
Price
$37.7
Updated
2020/06/24
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4-Hydroxyphenylacetic acid Chemical Properties,Usage,Production

Description

4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid.

Referrence

  1. Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84.
  2. Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115. 
  3. Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825.

Chemical Properties

white to cream or light tan crystalline powder

Uses

A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.

Purification Methods

Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]

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4-Hydroxyphenylacetic acid Suppliers

Taizhou Sunny Chemical Co.,Ltd
Tel
+86-523-86920899 13951172783
Fax
+86-523-86926789
Email
sales@suningchemical.com jwhua@suningchemical.com
Country
China
ProdList
12
Advantage
62
Wuxi Jingyao Bio-Technology Co., Ltd.
Tel
510-88770633-
Email
jingyaobiotech@126.com;
Country
China
ProdList
257
Advantage
55
Hangzhou YiDi Industrial Co., Ltd.
Tel
0571-82609104-
Fax
0571-82691158
Email
yidipharma@163.com
Country
China
ProdList
117
Advantage
58
Beijing xinyanhui pharmaceutical research and development co., LTD
Email
1461866103@qq.com
Country
China
ProdList
6293
Advantage
58
Beijing Holiyang Chemical Co. Ltd.
Tel
010-69380220-
Fax
010-56108838
Email
holiyangchem@163.com
Country
China
ProdList
3353
Advantage
56
Chengdu bioauto bio-pharmaceutical Technology Co. , Ltd.
Tel
028-61706249-
Email
3491899930@qq.com
Country
China
ProdList
2203
Advantage
58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
0536-2101172- ;
Fax
0536-2101172
Email
sdfantai@163.com;sdfantai@163.com
Country
China
ProdList
554
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96504
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40268
Advantage
62
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5952
Advantage
61
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View Lastest Price from 4-Hydroxyphenylacetic acid manufacturers

Anhui Rencheng Technology Co., Ltd
Product
4-Hydroxyphenylacetic acid 156-38-7
Price
US $1.00-89.00/KG
Min. Order
0.5KG
Purity
>99%
Supply Ability
20tons
Release date
2021-01-06
Hebei Chisure Biotechnology Co.LTD
Product
4-Hydroxyphenylacetic acid 156-38-7
Price
US $100.00/KG
Min. Order
1KG
Purity
99
Supply Ability
5tons
Release date
2020-12-29
Hebei Miaobian Biotechnology Co., Ltd
Product
4-Hydroxyphenylacetic acid 156-38-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99.99
Supply Ability
10Ton
Release date
2020-11-27

156-38-7, 4-Hydroxyphenylacetic acidRelated Search:


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