4-Hydroxybenzyl cyanide

Product Name: 4-Hydroxybenzyl cyanide
CAS No.: 14191-95-8
Chemical Name: 4-Hydroxybenzyl cyanide
Synonyms: 2-(4-HYDROXYPHENYL)ACETONITRILE;4-HYDROXYPHENYLACETONITRILE;4-Hydroxybenzyl;4-cyanomethylphenol;4-Hydroxybenzyl cyan;4-Hydroxybenzylnitrile;4-HYDROXY BENZYLCYARIDE;4-HYDROXYBENZYL CYANIDE;P-HYDROXYBENZYL CYANIDE;p-Hydroxybenzacetonitrile
CBNumber: CB2411323
Molecular Formula: C8H7NO
Formula Weight: 133.15
MOL File: 14191-95-8.mol

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4-Hydroxybenzyl cyanide Property

Melting point:: 67-70 °C (lit.)
Boiling point:: 330 °C/756 mmHg (lit.)
Density: 1.1475 (rough estimate)
refractive index: 1.5260 (estimate)
Flash point:: 178 °C
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, DMSO, Methanol (Slightly)
pka: 9.63±0.13(Predicted)
form: Solid
color: Light Brown to Beige
Water Solubility: slightly soluble
BRN: 1934470
Exposure limits: NIOSH: IDLH 25 mg/m3
InChIKey: AYKYOOPFBCOXSL-UHFFFAOYSA-N
LogP: 0.591 (est)
CAS DataBase Reference: 14191-95-8(CAS DataBase Reference)
NIST Chemistry Reference: 4-Hydroxyphenylacetic acid nitrile(14191-95-8)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 36/37-36/37/39-26
RIDADR: 3439
WGK Germany: 3
RTECS: AM0530000
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29269095

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H21101
Product name: 4-Hydroxyphenylacetonitrile
Purity: 98%
Packaging: 5g
Price: $25.46
Updated: 2025/07/31

Sigma-Aldrich

Product number: H21101
Product name: 4-Hydroxyphenylacetonitrile
Purity: 98%
Packaging: 25g
Price: $38.28
Updated: 2025/07/31

TCI Chemical

Product number: H0657
Product name: 4-Hydroxybenzyl Cyanide
Purity: >99.0%(GC)
Packaging: 25g
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: H0657
Product name: 4-Hydroxybenzyl Cyanide
Purity: >99.0%(GC)
Packaging: 500g
Price: $453
Updated: 2023/01/07

TCI Chemical

Product number: H0657
Product name: 4-Hydroxybenzyl Cyanide
Purity: >99.0%(GC)
Packaging: 5g
Price: $30
Updated: 2025/07/31

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4-Hydroxybenzyl cyanide Chemical Properties,Usage,Production

Chemical Properties

Light Brown Solid

Uses

4-Hydroxyphenylacetonitrile (cas# 14191-95-8) is a compound useful in organic synthesis.

Definition

ChEBI: A hydroxynitrile that is phenylacetonitrile substituted by a hydroxy group at position 4.

Synthesis

104-47-2

14191-95-8

General procedure for the synthesis of 2-(4-hydroxyphenyl)acetonitrile from 2-(4-methoxyphenyl)acetonitrile: 2-(4-methoxyphenyl)acetonitrile (500 g, 3.397 mol) was slowly added to a stirred suspension of aluminum chloride (1358.86 g, 10.19 mol) in toluene (2100 ml) over a period of 20-30 min at room temperature. The reaction mixture was gradually warmed up to 70°C and maintained at this temperature for 4-6 hours. The reaction progress was monitored by TLC (unfolding agent: 5% ethyl acetate/hexane). Upon completion of the reaction, the mixture was slowly poured into pre-cooled aqueous hydrochloric acid solution (3000 ml of water; 667 ml of concentrated hydrochloric acid), keeping the temperature below 20°C. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3 x 500 ml). The organic layers were combined, washed with water (2 x 500 ml) and dried over anhydrous sodium sulfate (50 g). The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was stirred with a mixture of hexane (800 ml) and ethyl acetate (40 ml) for 1 h. The solid product was collected by filtration and washed with hexane (300 ml). The resulting light brown product was dried under vacuum at 35-40°C. Yield: 431.6 g (95.41% yield); HPLC purity: 99.56%; Melting point: 70-71.6 °C (DMSO-d6).1H NMR (DMSO-d6, δ ppm): 9.55 (s, 1H, ArOH), 7.15 (d, 2H, ArH), 6.80 (d, 2H, ArH), 3.84 (s, 2H , CH2).13C NMR (DMSO-d6, δ ppm): 156.99, 129.40, 121.21, 119.80, 115.85, 21.73. IR (KBr, cm-1): 3340.71, 2268.29, 1614.42, 1516.05, 1446.61, 1408.04, 1263.37, 1222.37, 1222.04. 1263.37, 1222.87, 1105.21, 943.19, 819.75, 759.95, 707.88, 578.64. GC-MS (m/z): 133 (base peak), 106, 90, 78.

References

[1] Patent: WO2009/84037, 2009, A2. Location in patent: Page/Page column 7; 8; 18-19
[2] European Journal of Organic Chemistry, 2007, # 21, p. 3449 - 3462
[3] Letters in Organic Chemistry, 2011, vol. 8, # 1, p. 48 - 52
[4] Journal of Chemical Research, 2004, # 10, p. 693 - 694
[5] Journal fuer Praktische Chemie (Leipzig), 1987, vol. 329, # 6, p. 963 - 974

4-Hydroxybenzyl cyanide Preparation Products And Raw materials

Raw materials

Preparation Products

4-Hydroxyphenylacetamide 4-HYDROXY-3-NITROPHENYLACETIC ACID

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4-Hydroxybenzyl cyanide Suppliers

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View Lastest Price from 4-Hydroxybenzyl cyanide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Hydroxybenzyl cyanide 14191-95-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-25

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Hydroxybenzyl cyanide 14191-95-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Hydroxybenzyl cyanide 14191-95-8
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-23

14191-95-8, 4-Hydroxybenzyl cyanideRelated Search:

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4-HYDROXYPHENYLACETONITRILE 99+%

55) PARA HYDROXY BENZYL CYANIDE

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PARA-HYDROXYPHENYLACETONITRILE

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2-(4-Hydroxyphenyl)acetonitrile , 97+%

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4-Hydroxyphenylacetonitrile 98%

4-HYDROXYBENZYL CYANIDE

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2-(4-HYDROXYPHENYL)ACETONITRILE

P-HYDROXYBENZYL CYANIDE

4-HydroxybenzylCyanide&gt

Para Hydroxy Phenyl Acetonitrile (PHPAcn)

4-Hydroxybenzylnitrile

4-Hydroxyphenyl acetonitrile (4-Hydroxybenzylcyanide) > 98% puriss for synthesis

4-Hydroxybenzyl cyanide, 10 mM in DMSO

4-Hydroxyphenylacetonitrile, 95%

14191-95-8

14191-91-8

14191-98-8

HOC6H4CH2CN

Nitrogen Compounds

Organic Building Blocks

Cyanides/Nitriles

C8 to C9

Building Blocks

Aromatics

Inhibitors

Aromatic Nitriles

john's

OLED