Ethyl 4-hydroxyphenylacetate

Product Name: Ethyl 4-hydroxyphenylacetate
CAS No.: 17138-28-2
Chemical Name: Ethyl 4-hydroxyphenylacetate
Synonyms: EPAN-003;AKOS 90925;ETHYL 4-HYDROXYPHENYLACETATE;2-(4-hydroxyphenyl)butanoate;Ethyl (p-Hydroxyphenyl)acetate;Ethyl4-Hydroxyphenylacetate>ETHYL-4-HYDROXYPHENYLACETIC ACID;Ethyl 2-(p-Hydroxyphenyl)acetate;ETHYL 2-(4-HYDROXYPHENYL)ACETATE;4-hydroxy-benzeneaceticaciethylester
CBNumber: CB0714983
Molecular Formula: C10H12O3
Formula Weight: 180.2
MOL File: 17138-28-2.mol

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Ethyl 4-hydroxyphenylacetate Property

Melting point:: 36-38°C
Boiling point:: 187-189°C 20mm
Density: 1.146±0.06 g/cm3(Predicted)
refractive index: 1.52
Flash point:: 187-189°C/20mm
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform
form: Brown Semi-Solid
pka: 9.84±0.15(Predicted)
color: White or Colorless to Light yellow
LogP: 1.760 (est)
CAS DataBase Reference: 17138-28-2(CAS DataBase Reference)
NIST Chemistry Reference: Benzeneacetic acid, 4-hydroxy-, ethyl ester(17138-28-2)
EPA Substance Registry System: Benzeneacetic acid, 4-hydroxy-, ethyl ester (17138-28-2)

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Safety

Safety Statements: 22-24/25
TSCA: Yes
HazardClass: IRRITANT
HS Code: 2916340000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PH011119
Product name: ethyl (4-hydroxyphenyl)acetate
Purity: AldrichCPR
Packaging: 500mg
Price: $172
Updated: 2023/06/20

TCI Chemical

Product number: E1034
Product name: Ethyl 4-Hydroxyphenylacetate
Purity: >98.0%(GC)
Packaging: 5g
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: E1034
Product name: Ethyl 4-Hydroxyphenylacetate
Purity: >98.0%(GC)
Packaging: 25g
Price: $170
Updated: 2025/07/31

TRC

Product number: E919080
Product name: Ethyl 4-Hydroxyphenylacetate
Packaging: 100g
Price: $185
Updated: 2021/12/16

TRC

Product number: E919080
Product name: Ethyl 4-Hydroxyphenylacetate
Packaging: 1g
Price: $45
Updated: 2021/12/16

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Ethyl 4-hydroxyphenylacetate Chemical Properties,Usage,Production

Chemical Properties

Brown Semi-Solid

Uses

Ethyl 4-hydroxyphenylacetate is a useful synthetic intermediate for the preparation of novel antiinflammatory agents.

Synthesis

156-38-7

64-17-5

17138-28-2

4-Hydroxyphenylacetic acid (10.0 g, 65.7 mmol), anhydrous ethanol (120 mL), and concentrated hydrochloric acid (1 mL) were added to a round bottom flask. The reaction mixture was heated to reflux for 1 h and subsequently cooled to room temperature. The reaction mixture was neutralized in a small amount with saturated aqueous sodium bicarbonate solution. Most of the ethanol was evaporated under reduced pressure. The aqueous phase was extracted with ethyl acetate and the organic phase was sequentially washed well with water and dried with anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the target product ethyl p-hydroxyphenylacetate as an oil (11.8 g, 100% yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 7.13 (d, 2H), 6.76 (d, 2H), 5.10 (s, 1H), 4.15 (q, 2H), 3.36 (s, 2H), 1.26 (t, 3H).

target

MAO

References

[1] Patent: WO2006/20916, 2006, A2. Location in patent: Page/Page column 79
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 22, p. 8092 - 8105
[3] Synthesis, 2003, # 16, p. 2479 - 2482
[4] Patent: US2003/191181, 2003, A1. Location in patent: Page/Page column 10; 15
[5] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1651 - 1656

Ethyl 4-hydroxyphenylacetate Preparation Products And Raw materials

Raw materials

Ethanol 4-Hydroxyphenylacetic acid

Preparation Products

2-[3-(2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate

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Ethyl 4-hydroxyphenylacetate Suppliers

Americas 1 Belgium 1 Canada 2 China 162 Europe 1 France 1 Germany 6 India 15 Japan 1 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 40 USA 1 Global 252

J & K SCIENTIFIC LTD.

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Alfa Aesar

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TAIYUAN RHF CO.,LTD.

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Ark Pharm, Inc.

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Energy Chemical

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Capot Chemical Co., Ltd

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Pure Chemistry Scientific Inc.

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Adamas Reagent, Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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Country: China
ProdList: 42934
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
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View Lastest Price from Ethyl 4-hydroxyphenylacetate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 4-hydroxyphenylacetate 17138-28-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-02

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethyl 4-hydroxyphenylacetate 17138-28-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethyl 4-hydroxyphenylacetate 17138-28-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

17138-28-2, Ethyl 4-hydroxyphenylacetateRelated Search:

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17138-28-2

171-38-2

Aromatic Esters

Aromatics

Intermediates