2,6-Dichloronitrobenzene
- Product Name
- 2,6-Dichloronitrobenzene
- CAS No.
- 601-88-7
- Chemical Name
- 2,6-Dichloronitrobenzene
- Synonyms
- 2,6-Dichloronitrobenzene;2,6-Dichloronitrobenezene;1-Nitro-2,6-dichlorobenzene;Benzene, 1,3-dichloronitro-;1,3-Dichloro-2-nitrobenzene;1,3-DICHLORO-3-NITROBENZENE;Benzene, 1,3-dichloro-2-nitro-;1,3-Dichloro-2-nitrobenzene>TIANFUCHEM--High purity 2,6-Dichloronitrobenzene factory price
- CBNumber
- CB8500733
- Molecular Formula
- C6H3Cl2NO2
- Formula Weight
- 192
- MOL File
- 601-88-7.mol
2,6-Dichloronitrobenzene Property
- Melting point:
- 71 °C
- Boiling point:
- 130 °C / 8mmHg
- Density
- 1.6030
- refractive index
- 1.5929 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Pale Yellow to Pale Green
- CAS DataBase Reference
- 601-88-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,3-dichloro-2-nitrobenzene(601-88-7)
Safety
- Hazard Codes
- T
- RIDADR
- 1578
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D3449
- Product name
- 1,3-Dichloro-2-nitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $88
- Updated
- 2025/07/31
- Product number
- D438275
- Product name
- 1,3-Dichloro-2-nitrobenzene
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- F887
- Product name
- 2,6-Dichloronitrobenzene
- Packaging
- 25g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- 4654-5-Z7
- Product name
- 2,6-Dichloronitrobenzene
- Packaging
- 25g
- Price
- $44
- Updated
- 2021/12/16
- Product number
- CS-W007920
- Product name
- 1,3-Dichloro-2-nitrobenzene
- Purity
- 99.55%
- Packaging
- 100g
- Price
- $100
- Updated
- 2021/12/16
2,6-Dichloronitrobenzene Chemical Properties,Usage,Production
Uses
1,3-Dichloro-2-nitrobenzene is an olfactory mucosa (OM) toxicants.Also, it is a starting material for 9-Chloro Quetiapine (C366040), which is an impurity of Quetiapine hemifumarate (Q510000), a dibenzothiazepine antipsychotic medication used in the treatment of schizophrenia.
Synthesis
608-31-1
601-88-7
2.1.5. Synthesis of 1,3-dichloro-2-nitrobenzene[4]. 2,6-Dichloroaniline (8.10 g, 50.0 mmol) was dissolved in dichloromethane (200 mL) and the solution was cooled to 0 °C. A solution of 3-chloroperbenzoic acid (24.6 g, 100 mmol) in dichloromethane (250 mL) was slowly added dropwise at 0 °C for a controlled time of 1.5 hours. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. Subsequently, the reaction mixture was diluted with dichloromethane (250 mL). The reaction mixture was washed sequentially with 2 wt% aqueous sodium thiosulfate (2 x 100 mL), aqueous sodium bicarbonate (4 x 50 mL) and deionized water (200 mL). The organic layer was dried with magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was suspended in n-hexane (40 mL), sonicated for 5 min and filtered, and the filter cake was washed with n-hexane (2 x 20 mL) to afford 1,3-dichloro-2-nitrobenzene (6.63 g, 37.7 mmol, 75% yield) as a beige solid.
References
[1] Patent: US2014/163256, 2014, A1. Location in patent: Paragraph 0161-0162
[2] Tetrahedron Letters, 1983, vol. 24, # 14, p. 1505 - 1508
[3] Tetrahedron, 1987, vol. 43, # 8, p. 1753 - 1758
[4] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 768 - 778
[5] Journal of Medicinal Chemistry, 1968, vol. 11, # 4, p. 814 - 819
2,6-Dichloronitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dichloronitrobenzene manufacturers
- Product
- 2,6-Dichloronitrobenzene 601-88-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.6%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
- Product
- 2,6-Dichloronitrobenzene 601-88-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12