3,4-Dichloronitrobenzene Property

Melting point:

39-41 °C(lit.)

Boiling point:

255-256 °C(lit.)

Density 

1.48 g/cm3 (55℃)

vapor pressure 

0.01 hPa (20 °C)

refractive index 

1.5929 (estimate)

Flash point:

255 °F

storage temp. 

Store below +30°C.

solubility 

0.151g/l

form 

Crystalline Mass

color 

Yellow to brown

Water Solubility 

151 mg/L (20 ºC)

FreezingPoint 

30~31℃

BRN 

1818163

Stability:

Stable. Incompatible with strong oxidizing agents, strong bases.

CAS DataBase Reference

99-54-7(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,2-dichloro-4-nitro-(99-54-7)

EPA Substance Registry System

3,4-Dichloronitrobenzene (99-54-7)

Safety

Hazard Codes 

Xn,N

Risk Statements 

22-36-43-51/53

Safety Statements 

26-36/37-61-39-24/25

RIDADR 

2811

WGK Germany 

3

RTECS 

CZ5250000

Autoignition Temperature

420 °C

TSCA 

Yes

HazardClass 

9

PackingGroup 

III

HS Code 

29049085

Hazardous Substances Data

99-54-7(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 643 mg/kg LD50 dermal Rat > 2000 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3,4-Dichloronitrobenzene Chemical Properties,Usage,Production

Chemical Properties

colourless to yellow crystals or beige powder

Uses

1,2-Dichloro-4-nitrobenzene is an intermediate in the synthesis of agrochemicals. Studies have been conducted to use 1,2-Dichloro-4-nitrobenzene as an organic intermediate for the synthetic preparation of ciprofloxacin (C482500).

Uses

1,2-Dichloro-4-nitrobenzene is an intermediate in the synthesis of agrochemicals. Studies have been conducted to use 1,2-Dichloro-4-nitrobenzene as an organic intermediate for the synthetic preparati on of ciprofloxacin (C482500).

Production Methods

Nitration of 1,2-dichlorobenzene with mixed acid at 35 – 60 ℃ results in a mixture of 3-nitro (10 %) and 4-nitro (90 %) isomers, which are separated by crystallization. A more expensive process (two stages from chlorobenzene) is based on chlorination of molten 4-chloronitrobenzene (90 – 100 ℃) by a process similar to that used for 3- chloronitrobenzene production. Chlorination has the advantage of giving a pure product, but it cannot be used if the isomeric 1,2-dichloro-3-nitrobenzene is also required.

Synthesis Reference(s)

The Journal of Organic Chemistry, 42, p. 3494, 1977 DOI: 10.1021/jo00442a009

General Description

Colorless crystals or light beige solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Can react vigorously with oxidizing materials.

Fire Hazard

3,4-Dichloronitrobenzene is combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from absolute EtOH. [Beilstein 5 IV 726.]