2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
- Product Name
- 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
- CAS No.
- 106809-14-7
- Chemical Name
- 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
- Synonyms
- CAS:106809-14-7;TIMTEC-BB SBB003130;2,4-Dichloro-3-nitro-5-fluorob;2,4-Dichloro-3-hitro-5-fluorobenzoicacid;2,4-Dichloro-5-Flouro-3-Nitrobenzoic Acid;2,4-dichloro-5-fluoro-3-cyanobenzoic acid;2,4-DICHLORO-5-FLUORO-3-NITROBENZOIC ACID;5-Fluoro-2,4-dichloro-3-nitrobenzoic acid;2,4-difluoro-5-fluoro-3-nitro benzoic acid;2,4-DICHLORO-3-NITRO-5-FLUORO BENZOIC ACID
- CBNumber
- CB8238463
- Molecular Formula
- C7H2Cl2FNO4
- Formula Weight
- 254
- MOL File
- 106809-14-7.mol
2,4-Dichloro-5-fluoro-3-nitrobenzoic acid Property
- Melting point:
- 193-197 °C (lit.)
- Boiling point:
- 390.4±42.0 °C(Predicted)
- Density
- 1.7139 (estimate)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 1.51±0.24(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 106809-14-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 553867
- Product name
- 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $25.6
- Updated
- 2023/01/07
- Product number
- 553867
- Product name
- 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $40.5
- Updated
- 2023/01/07
- Product number
- D438725
- Product name
- 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
- Packaging
- 25g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-W016760
- Product name
- 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
- Packaging
- 100g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- FD67947
- Product name
- 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
- Packaging
- 100g
- Price
- $165
- Updated
- 2021/12/16
2,4-Dichloro-5-fluoro-3-nitrobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
2,4-Dichloro-5-fluoro-3-nitrobenzoic acid may be used to synthesize:
- ethyl 3-(N,N-dimethylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)acrylate
- 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- ethyl-3-(N,N-dimethylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl) acrylate
- substituted 4(1H)-oxoquinoline-3-carboxylic acid
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 25, p. 927, 1988 DOI: 10.1002/jhet.5570250343
General Description
2,4-Dichloro-5-fluoro-3-nitrobenzoic acid can be prepared from 2,4-dichloro-5-fluorobenzoic acid.
Synthesis
704-10-9
106809-14-7
General procedure for the synthesis of 2,4-dichloro-5-fluoro-3-nitrobenzoic acid from 2',4'-dichloro-5'-fluoroacetophenone: 55 g (0.55 mol) of concentrated sulfuric acid was added to a 250 mL three-necked flask with a stirrer and reflux condenser tube. Under stirring (stirring speed of 400 r/min), 19.29 g (0.3 mol) fuming nitric acid was slowly added to the three-necked flask. Subsequently, the reaction mixture was warmed up to 103 °C and 10.46 g (0.05 mol) of pre-melted 2,4-dichloro-5-fluoroacetophenone was slowly added dropwise at this temperature, controlling the dropwise temperature to be between 103 and 110 °C. After the dropwise addition was completed, the reaction temperature was maintained at 106 °C to continue the reaction for 3 hours. After completion of the reaction, the mixture was cooled to 10 °C and separated by filtration. The filtrate was recovered and set aside, and the filter cake was washed with water. Finally, the filter cake was recrystallized with toluene to give 11.67 g of 2,4-dichloro-5-fluoro-3-nitrobenzoic acid with 99% purity and 91% yield.
References
[1] Patent: CN103922942, 2016, B. Location in patent: Paragraph 0026; 0027
[2] Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 927 - 930
2,4-Dichloro-5-fluoro-3-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Dichloro-5-fluoro-3-nitrobenzoic acid Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
View Lastest Price from 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid manufacturers
- Product
- 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid 106809-14-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-08