3-FLUORO-5-NITROBENZOIC ACID

Product Name: 3-FLUORO-5-NITROBENZOIC ACID
CAS No.: 14027-75-9
Chemical Name: 3-FLUORO-5-NITROBENZOIC ACID
Synonyms: 3-Fluoro-5-NitrobenzoicAci;3-FLUORO-5-NITROBENZOIC ACID;3-Fluoro-5-nitrobenzoicacid,97%;Benzoic acid, 3-fluoro-5-nitro-;3-Fluoro-5-nitrobenzoic acid ,98%;3-FLUORO-5-NITROBENZOIC ACID ISO 9001：2015 REACH
CBNumber: CB0683670
Molecular Formula: C7H4FNO4
Formula Weight: 185.11
MOL File: 14027-75-9.mol

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3-FLUORO-5-NITROBENZOIC ACID Property

Melting point:: 125°C
Boiling point:: 341.2±27.0 °C(Predicted)
Density: 1.568±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.14±0.10(Predicted)
form: Solid
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C7H4FNO4/c8-5-1-4(7(10)11)2-6(3-5)9(12)13/h1-3H,(H,10,11)
InChIKey: VIPUIECMSDQUIK-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC([N+]([O-])=O)=CC(F)=C1
CAS DataBase Reference: 14027-75-9(CAS DataBase Reference)

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: F595088
Product name: 3-Fluoro-5-nitrobenzoicacid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: F595088
Product name: 3-Fluoro-5-nitrobenzoicacid
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC48725
Product name: 3-Fluoro-5-nitrobenzoicacid
Purity: 97%
Packaging: 1g
Price: $77
Updated: 2021/12/16

Matrix Scientific

Product number: 074022
Product name: 3-Fluoro-5-nitrobenzoic acid
Purity: 95+%
Packaging: 1g
Price: $25
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-3-94
Product name: 3-Fluoro-5-nitrobenzoic acid
Purity: 97%
Packaging: 1g
Price: $85
Updated: 2021/12/16

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3-FLUORO-5-NITROBENZOIC ACID Chemical Properties,Usage,Production

Uses

3-fluoro-5-nitrobenzoic acid is an industrial chemical with a variety of uses. It is used as an intermediate in the production of other chemicals and pharmaceuticals. 3-Fluoro-5-nitrobenzoic acid can be activated to form the corresponding sodium salt, which has been used as a reagent for organic synthesis. This chemical can also be used to produce n-oxides, such as phenoxides and nitrophenols. 3-Fluoro-5-nitrobenzoic acid is also used to synthesize industrial chemicals, including chlorides and benzene derivatives.

Synthesis

618-84-8

95-50-1

14027-75-9

An acetonitrile (50 mL) slurry of nitrosonium tetrafluoroborate (3.53 g, 30.2 mM) was cooled in an ice bath under argon protection and stirred vigorously. Subsequently, 3-amino-5-nitrobenzoic acid (5.0 g, 27.5 mM) was added in three batches. When the addition was complete, the reaction mixture was gradually warmed to room temperature and stirred continuously for 48 hours. Upon completion of the reaction, 1,2-dichlorobenzene (50 mL) was added and the acetonitrile was removed by distillation under reduced pressure. Subsequently, the mixture was heated to 170°C and maintained for 30 minutes until the gas stopped escaping. After cooling, the reaction mixture was poured into dichloromethane (200 mL) and extracted with NaHCO3 solution. The aqueous phase was backwashed with dichloromethane, acidified with 2 M hydrochloric acid, and then the organic phase was extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, washed with brine and dried with MgSO4. The crude product was purified by silica gel column chromatography using a gradient elution from dichloromethane/acetic acid (99:1) to dichloromethane/isopropanol/acetic acid (80:20:1), resulting in 3-fluoro-5-nitrobenzoic acid (3.26 g, 64% yield). The NMR hydrogen spectrum (DMSO-d6) data were as follows: δ 8.14 (dm, 1H); δ 8.37 (dt, 1H); δ 8.46 (m, 1H).

References

[1] Patent: US5478820, 1995, A

3-FLUORO-5-NITROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUORO-5-NITROBENZOIC ACID Suppliers

China 128 Germany 1 India 2 Ukraine 1 United Kingdom 7 United States 14 Global 153

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
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J & K SCIENTIFIC LTD.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from 3-FLUORO-5-NITROBENZOIC ACID manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3-FLUORO-5-NITROBENZOIC ACID 14027-75-9
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-24

Hebei Zhanyao Biotechnology Co. Ltd

Product: 3-FLUORO-5-NITROBENZOIC ACID 14027-75-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-FLUORO-5-NITROBENZOIC ACID 14027-75-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

14027-75-9, 3-FLUORO-5-NITROBENZOIC ACIDRelated Search:

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3-FLUORO-5-NITROBENZOIC ACID

3-Fluoro-5-nitrobenzoic acid ,98%

Benzoic acid, 3-fluoro-5-nitro-

3-Fluoro-5-nitrobenzoicacid,97%

3-Fluoro-5-NitrobenzoicAci

3-FLUORO-5-NITROBENZOIC ACID ISO 9001：2015 REACH

14027-75-9

Fluorine series