2,6-DIFLUORO-3-NITROBENZOIC ACID

Product Name: 2,6-DIFLUORO-3-NITROBENZOIC ACID
CAS No.: 83141-10-0
Chemical Name: 2,6-DIFLUORO-3-NITROBENZOIC ACID
Synonyms: RARECHEM AL BO 0441;2,6-Difluro-3-nitrobenzoic acid;2,6-DIFLUORO-3-NITROBENZOIC ACID;2,6-Difluoro-3-nitrobenzoicacid98%;3-Carboxy-2,4-difluoronitrobenzene;Benzoic acid, 2,6-difluoro-3-nitro-;2,6-Difluoro-3-nitrobenzoic acid 98%;2,6-DIFLUORO-3-NITROBENZOIC ACID ISO 9001：2015 REACH;Benzoic acid,2,6-difluoro-3-nitro- (Related Reference)
CBNumber: CB0676032
Molecular Formula: C7H3F2NO4
Formula Weight: 203.1
MOL File: 83141-10-0.mol

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2,6-DIFLUORO-3-NITROBENZOIC ACID Property

Melting point:: 92-96°C
Boiling point:: 335.5±42.0 °C(Predicted)
Density: 1.661
storage temp.: Sealed in dry,Room Temperature
pka: 1.48±0.29(Predicted)
form: powder to crystal
color: White to Light yellow
InChI: InChI=1S/C7H3F2NO4/c8-3-1-2-4(10(13)14)6(9)5(3)7(11)12/h1-2H,(H,11,12)
InChIKey: PDDHSNODMFIIRV-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=C(F)C=CC([N+]([O-])=O)=C1F
CAS DataBase Reference: 83141-10-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-24/25
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5138
Product name: 2,6-Difluoro-3-nitrobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $66
Updated: 2025/07/31

TCI Chemical

Product number: D5138
Product name: 2,6-Difluoro-3-nitrobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $260
Updated: 2025/07/31

TRC

Product number: D447138
Product name: 2,6-Difluoro-3-nitrobenzoic Acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: D447138
Product name: 2,6-Difluoro-3-nitrobenzoic Acid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: D447138
Product name: 2,6-Difluoro-3-nitrobenzoic Acid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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2,6-DIFLUORO-3-NITROBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

2,6-Difluoro-3-nitrobenzoic acid is a benzoic acid derivative that contains reactive substituent fluorine atoms and nitro groups in its molecular structure. The substance is mainly used as a reagent for organic synthesis or as a component of pharmaceutical intermediates. It is used in the synthesis of B-Raf kinase inhibitors, such as vemurafenib, which causes programmed cell death (apoptosis) in melanoma cell lines. In addition, it is used in the synthesis of fluoroquinolone antibacterial agents.

Synthesis

385-00-2

83141-10-0

General procedure for the synthesis of 2,6-difluoro-3-nitrobenzoic acid from 2,6-difluorobenzoic acid: Concentrated sulfuric acid (5 mL) was slowly added to 2,6-difluorobenzoic acid (1.4 g, 9 mmol) at 0 °C, followed by gradual addition of potassium nitrate (1 g, 9.9 mmol). After warming the reaction mixture to room temperature, stirring was continued for 24 hours. After completion of the reaction, ice water was poured into the reaction mixture and extracted with ethyl acetate. The organic layer was dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The solid in the concentrated filtrate was washed with ether and dried to give 2,6-difluoro-3-nitrobenzoic acid (1.3 g, yield: 71%). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.37 (td, J = 9.2,5.6 Hz, 1H), 7.46 (t, J = 9.2 Hz, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2647 - 2666
[2] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 10, p. 3530 - 3543
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 10, p. 1905 - 1917
[4] Synlett, 2012, vol. 23, # 7, p. 1039 - 1042
[5] Patent: EP2647637, 2013, A2. Location in patent: Paragraph 0055

2,6-DIFLUORO-3-NITROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-DIFLUORO-3-NITROBENZOIC ACID Suppliers

Americas 1 China 136 Europe 1 Germany 3 India 4 Italy 1 Japan 1 United Kingdom 7 United States 14 Global 168

Shanghai Harvest Chemical Industrial Co., Ltd.

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View Lastest Price from 2,6-DIFLUORO-3-NITROBENZOIC ACID manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2,6-DIFLUORO-3-NITROBENZOIC ACID 83141-10-0
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,6-DIFLUORO-3-NITROBENZOIC ACID 83141-10-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Shaanxi Dideu Medichem Co. Ltd

Product: 2,6-Difluoro-3-nitrobenzoic acid 83141-10-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 tons
Release date: 2020-01-10

83141-10-0, 2,6-DIFLUORO-3-NITROBENZOIC ACIDRelated Search:

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RARECHEM AL BO 0441

2,6-Difluoro-3-nitrobenzoic acid 98%

2,6-Difluoro-3-nitrobenzoicacid98%

2,6-DIFLUORO-3-NITROBENZOIC ACID

2,6-Difluro-3-nitrobenzoic acid

Benzoic acid,2,6-difluoro-3-nitro- (Related Reference)

3-Carboxy-2,4-difluoronitrobenzene

Benzoic acid, 2,6-difluoro-3-nitro-

2,6-DIFLUORO-3-NITROBENZOIC ACID ISO 9001：2015 REACH

83141-10-0

83141-10-1

Benzene series

Benzoic acid

NitroCompounds

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

blocks

Carboxes

FluoroCompounds