2-Fluoro-5-nitrobenzoic acid
- Product Name
- 2-Fluoro-5-nitrobenzoic acid
- CAS No.
- 7304-32-7
- Chemical Name
- 2-Fluoro-5-nitrobenzoic acid
- Synonyms
- NSC 133450;BUTTPARK 32\01-76;RARECHEM AL BO 0445;uoro-5-nitrobenzoic acid;2-FLUORO-5-NITROBENZOIC ACID;2-Fluoro-5-nitrobenzotc acid;2-FLUORO-5-NITRROBENZOIC ACID;2-Fluoro-5-nitrobenzoicAcid>3-Carboxy-4-fluoronitrobenzene;2-Fluoro-5-nitrobenzoicacid98%
- CBNumber
- CB9138113
- Molecular Formula
- C7H4FNO4
- Formula Weight
- 185.11
- MOL File
- 7304-32-7.mol
2-Fluoro-5-nitrobenzoic acid Property
- Melting point:
- 142-144 °C (lit.)
- Boiling point:
- 337.7±27.0 °C(Predicted)
- Density
- 1.568±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in chloroform, ethanol.
- pka
- 2.54±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to pale yellow
- BRN
- 1912835
- InChI
- InChI=1S/C7H4FNO4/c8-6-2-1-4(9(12)13)3-5(6)7(10)11/h1-3H,(H,10,11)
- InChIKey
- ICXSHFWYCHJILC-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC([N+]([O-])=O)=CC=C1F
- CAS DataBase Reference
- 7304-32-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 362654
- Product name
- 2-Fluoro-5-nitrobenzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $28.2
- Updated
- 2025/07/31
- Product number
- F0391
- Product name
- 2-Fluoro-5-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- F0391
- Product name
- 2-Fluoro-5-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $201
- Updated
- 2025/07/31
- Product number
- F593775
- Product name
- 2-Fluoro-5-nitrobenzoic Acid
- Packaging
- 25g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- F593775
- Product name
- 2-Fluoro-5-nitrobenzoic Acid
- Packaging
- 50g
- Price
- $135
- Updated
- 2021/12/16
2-Fluoro-5-nitrobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support, synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols, in the synthesis of oxazepines.
Uses
2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:
- dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support
- synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols
- in the synthesis of oxazepines
General Description
2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product.
Synthesis
445-29-4
7304-32-7
General procedure for the synthesis of 2-fluoro-5-nitrobenzoic acid from o-fluorobenzoic acid: Nitric acid (60% solution, 5.0 mL) was slowly added dropwise to pre-cooled concentrated sulfuric acid (5.0 mL), and the reaction temperature was controlled to not exceed 10 °C. Subsequently, o-fluorobenzoic acid (2.1 g, 15.0 mmol) was added in batches and the reaction temperature was maintained between 15 and 25 °C. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction was quenched by addition of ice water and the precipitate was collected by filtration. The product was dried at room temperature to give the intermediate 2-fluoro-5-nitrobenzoic acid as a white powder. Yield: 93%; Melting point: 135-137 °C; 1H NMR (300 MHz, DMSO-d6): δ=7.32 (t, 1H, H3, 3JH3_H4=JH3-F=9.2 Hz), 8.43 (dt, 1H, H4, 3JH4_H3=9.2 Hz, 4JH4_F=4JH4_H6=3.5 Hz), 8.89 (dd, 1H, H6, 4JH6_F=5.8 Hz, 4JH6_H4=3.0 Hz); 13C NMR (75 MHz, DMSO-d6): δ=118.7 (d, C1, 2JC-F=10.9 Hz), 118.7 (d, C3, 2JC-F=25.0 Hz), 128.9 (d, C6, 3JC -F=2.2 Hz), 130.6 (d, C4, 3JC-F=10.9 Hz), 143.9 (C5), 165.7 (d, C2, 1JC-F=272.0 Hz), 166.7 (d, COOH, 3JC-F=3.8 Hz).
References
[1] Patent: WO2012/85003, 2012, A1. Location in patent: Page/Page column 83
[2] Journal of Organic Chemistry, 2008, vol. 73, # 2, p. 538 - 549
[3] Journal of Heterocyclic Chemistry, 1998, vol. 35, # 6, p. 1301 - 1304
[4] Journal of Medicinal Chemistry, 2003, vol. 46, # 10, p. 1905 - 1917
[5] Australian Journal of Chemistry, 1981, vol. 34, # 5, p. 969 - 979
2-Fluoro-5-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Fluoro-5-nitrobenzoic acid manufacturers
- Product
- 2-Fluoro-5-nitrobenzoic acid 7304-32-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-12
- Product
- 2-Fluoro-5-nitrobenzoic acid 7304-32-7
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 2-Fluoro-5-nitrobenzoic acid 7304-32-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10