4-Fluoro-2-nitrobenzoic acid
- Product Name
- 4-Fluoro-2-nitrobenzoic acid
- CAS No.
- 394-01-4
- Chemical Name
- 4-Fluoro-2-nitrobenzoic acid
- Synonyms
- BUTTPARK 45\01-65;RARECHEM AL BO 1973;Afatinib Impurity 98;2-Nitro-4-Fluoro Benzoic;4-Fluor-2-nitrobenzoesure;2-Nitro-4-Fluoroluere acid;2-NITRO-4-FLUOROBENZOIC ACID;4-Fluoro-2-nitrobenzotc acid;4-FLUORO-2-NITROBENZOIC ACID;2-Carboxy-5-fluoronitrobenzene
- CBNumber
- CB8774109
- Molecular Formula
- C7H4FNO4
- Formula Weight
- 185.11
- MOL File
- 394-01-4.mol
4-Fluoro-2-nitrobenzoic acid Property
- Melting point:
- 140-145 °C (lit.)
- Boiling point:
- 343.8±27.0 °C(Predicted)
- Density
- 1.568±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.14±0.25(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C7H4FNO4/c8-4-1-2-5(7(10)11)6(3-4)9(12)13/h1-3H,(H,10,11)
- InChIKey
- YLUCXHMYRQUERW-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(F)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 394-01-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 115452
- Product name
- 4-Fluoro-2-nitrobenzoic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $117
- Updated
- 2023/06/20
- Product number
- F0737
- Product name
- 4-Fluoro-2-nitrobenzoic Acid
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- F0737
- Product name
- 4-Fluoro-2-nitrobenzoic Acid
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $143
- Updated
- 2025/07/31
- Product number
- F595043
- Product name
- 4-Fluoro-2-nitrobenzoic acid
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 008773
- Product name
- 4-Fluoro-2-nitrobenzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
4-Fluoro-2-nitrobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Fluoro-2-nitrobenzoic acid has been used to study the reactions of substituted pyridines with the salicyl phosphate dianion.
Biochem/physiol Actions
4-Fluoro-2-nitrobenzoic acid enhances the binding of insulin to adipocytes.
Synthesis
446-10-6
394-01-4
The general procedure for synthesizing 2-nitro-4-fluorobenzoic acid from 2-nitro-4-fluorotoluene is as follows: referring to the method of Examples 2-31, a mixture of 4-fluoro-2-nitrotoluene (25.0 g, 161 mmol), potassium permanganate (102 g, 645 mmol), and water (500 mL) was heated to 100 °C and stirred for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through diatomaceous earth to remove insoluble manganese dioxide produced by the reduction of potassium permanganate. The filtrate was washed with diethyl ether and adjusted to acidity by adding concentrated hydrochloric acid. Subsequently, the organic material in the acidified aqueous phase was extracted with diethyl ether. The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure to give 2-nitro-4-fluorobenzoic acid (10.1 g, 34% yield). The product was confirmed by NMR hydrogen spectroscopy (CDCl3): δ 7.40 (1H, ddd, J = 2.6 Hz, 7.4 Hz, 8.8 Hz), 7.53 (1H, dd, J = 2.6 Hz, 7.6 Hz), 8.00 (1H, dd, J = 5.6 Hz, 8.8 Hz), 8.52 (1H, br s).
References
[1] Patent: US2003/187014, 2003, A1
[2] Journal of Biological Chemistry, 1954, vol. 207, p. 411,412
[3] Journal of the American Chemical Society, 1963, vol. 85, p. 1792 - 1797
[4] Collection of Czechoslovak Chemical Communications, 1960, vol. 25, p. 784 - 796
[5] Patent: US6635657, 2003, B1
4-Fluoro-2-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-2-nitrobenzoic acid manufacturers
- Product
- 4-Fluoro-2-nitrobenzoic acid 394-01-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.8%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21
- Product
- 4-Fluoro-2-nitrobenzoic acid 394-01-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25