5-Fluoro-2-nitrobenzoic acid
Uses- Product Name
- 5-Fluoro-2-nitrobenzoic acid
- CAS No.
- 320-98-9
- Chemical Name
- 5-Fluoro-2-nitrobenzoic acid
- Synonyms
- BUTTPARK 32\01-77;RARECHEM AL BO 0968;2-Nitro-5-fluorobozoic acid;5-FLUORO-2-NITROBENZOIC ACID;3-FLUORO-6-NITROBENZOIC ACID;5-Fluoro-2-nitrobenzotc acid;Benzoicacid, 5-fluoro-2-nitro-;5-Fluoro-2-nitrobenzoicacid98%;2-Carboxy-4-fluoronitrobenzene;5-Fluoro-2-nitrobenzoicAcid>
- CBNumber
- CB9111875
- Molecular Formula
- C7H4FNO4
- Formula Weight
- 185.11
- MOL File
- 320-98-9.mol
5-Fluoro-2-nitrobenzoic acid Property
- Melting point:
- 131-134 °C (lit.)
- Boiling point:
- 344.2±27.0 °C(Predicted)
- Density
- 1.568±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.89±0.25(Predicted)
- form
- Crystalline Powder
- color
- White to pale yellow
- InChI
- InChI=1S/C7H4FNO4/c8-4-1-2-6(9(12)13)5(3-4)7(10)11/h1-3H,(H,10,11)
- InChIKey
- GHYZIXDKAPMFCS-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(F)=CC=C1[N+]([O-])=O
- CAS DataBase Reference
- 320-98-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22-20/21/22
- Safety Statements
- 26-36-36/37/39-22
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 481904
- Product name
- 5-Fluoro-2-nitrobenzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $166
- Updated
- 2023/06/20
- Product number
- F0694
- Product name
- 5-Fluoro-2-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- F0694
- Product name
- 5-Fluoro-2-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $161
- Updated
- 2025/07/31
- Product number
- F595068
- Product name
- 5-Fluoro-2-nitrobenzoic Acid
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 4654-3-52
- Product name
- 5-Fluoro-2-nitrobenzoic acid
- Purity
- 98%
- Packaging
- 100g
- Price
- $65
- Updated
- 2021/12/16
5-Fluoro-2-nitrobenzoic acid Chemical Properties,Usage,Production
Uses
5-Fluoro-2-nitrobenzoic acid is used in the production of pharmaceuticals, dye carriers, plasticizers, fragrances and food preservatives, and is also used to improve the performance of alkyd resin coatings.
Chemical Properties
white to light yellow crystal powder
General Description
5-Fluoro-2-nitrobenzoic acid, an ortho-nitro benzoic acid derivative, can be prepared by the oxidation of 5-fluoro-2-nitrotoluene. It is an intermediate formed during the synthesis of N1-(2,4-dichlorophenyl)-2-amino-5-fluorobenzamide. It participates in the synthesis of novel quinazolinones that are potential inhibitors of p38α mitogen-activated protein kinase (MAPK).
Synthesis
455-38-9
320-98-9
a) General procedure for the synthesis of 5-fluoro-2-nitrobenzoic acid: 3-fluorobenzoic acid (7.9 g, 56 mmol) was dissolved in concentrated sulfuric acid (50 mL), and the solution was cooled to 0 °C. Fuming nitric acid (4.7 g, 67 mmol) was added dropwise with stirring. After the dropwise addition, the reaction mixture was slowly warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the mixture was carefully poured into water (750 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 5-fluoro-2-nitrobenzoic acid as a light yellow solid (9.6 g, 52 mmol, 93% yield).1H NMR (300 MHz, d6-DMSO) data for 5-fluoro-2-nitrobenzoic acid: δ 7.66 (m, 1H), 7.74 (m, 1H), 8.17 (m, 1H) ppm.
References
[1] Patent: US5514676, 1996, A
[2] Tetrahedron, 2006, vol. 62, # 31, p. 7284 - 7292
[3] Patent: WO2006/95014, 2006, A1. Location in patent: Page/Page column 41
[4] Patent: WO2004/74218, 2004, A2. Location in patent: Page 106
[5] Patent: US2008/139551, 2008, A1. Location in patent: Page/Page column 43
5-Fluoro-2-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Fluoro-2-nitrobenzoic acid Suppliers
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 4000
- Advantage
- 55
- Tel
- 13915872857
- hannengchemical@163.com
- Country
- China
- ProdList
- 96
- Advantage
- 58
- Tel
- 15865694623
- 1825792389@qq.com
- Country
- China
- ProdList
- 370
- Advantage
- 58
- Tel
- 19951442182
- sales@aribopharm.com
- Country
- China
- ProdList
- 1711
- Advantage
- 58
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2816
- Advantage
- 64
- Tel
- 18841123239 13840910170;
- 1798136513@qq.com
- Country
- China
- ProdList
- 121
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 0418-6530555 2855550
- Fax
- +86-418-6502885
- Country
- China
- ProdList
- 338
- Advantage
- 69
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
View Lastest Price from 5-Fluoro-2-nitrobenzoic acid manufacturers
- Product
- 5-Fluoro-2-nitrobenzoic acid 320-98-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 5-Fluoro-2-nitrobenzoic acid 320-98-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 5-Fluoro-2-nitrobenzoic acid 320-98-9
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12