2-Fluoro-3-nitrotoluene

Product Name: 2-Fluoro-3-nitrotoluene
CAS No.: 437-86-5
Chemical Name: 2-Fluoro-3-nitrotoluene
Synonyms: 2-FLUORO-1-METHYL-3-NITROBENZENE;2-Fluoro-3-nitrotoluen;2-fluoro-3-Nitrotoluol;2-Fluoro-3-nitrotluene;2-FLUORO-3-NITROTOLUENE;2-Fluoro-3-nitrotoluene>2-fluoro-3-methylnitrobenzene;2-Fluoro-3-maethylnitrobenzene;2-Fluoro-1-methyl-3-nitrobenzece;Benzene, 2-fluoro-1-methyl-3-nitro-
CBNumber: CB6402567
Molecular Formula: C7H6FNO2
Formula Weight: 155.13
MOL File: 437-86-5.mol

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2-Fluoro-3-nitrotoluene Property

Melting point:: 19℃
Boiling point:: 111℃/12mm
Density: 1.276
Flash point:: 98°(208°F)
refractive index: 1.5290
storage temp.: Sealed in dry,Room Temperature
form: Liquid
color: Colorless to pale yellow
InChI: InChI=1S/C7H6FNO2/c1-5-3-2-4-6(7(5)8)9(10)11/h2-4H,1H3
InChIKey: NBCNUIXYBLFJMI-UHFFFAOYSA-N
SMILES: C1(C)=CC=CC([N+]([O-])=O)=C1F
LogP: 1.423
CAS DataBase Reference: 437-86-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 34-36/37/38-20/22
Safety Statements: 26-36/37/39-45-36/37
Hazard Note: Harmful/Irritant
HazardClass: IRRITANT
HazardClass: 6.1
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0661
Product name: 2-Fluoro-3-nitrotoluene
Purity: >98.0%(GC)
Packaging: 5g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: F0661
Product name: 2-Fluoro-3-nitrotoluene
Purity: >98.0%(GC)
Packaging: 25g
Price: $130
Updated: 2025/07/31

TRC

Product number: F597703
Product name: 2-Fluoro-3-nitrotoluene
Packaging: 500mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F597703
Product name: 2-Fluoro-3-nitrotoluene
Packaging: 1g
Price: $55
Updated: 2021/12/16

TRC

Product number: F597703
Product name: 2-Fluoro-3-nitrotoluene
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

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2-Fluoro-3-nitrotoluene Chemical Properties,Usage,Production

Chemical Properties

Clear light yellow to yellow liquid

Uses

2-Fluoro-3-nitrotoluene is a class of fluorinated aromatic compounds. Compared with fluorinated aromatic compounds, fluorinated aromatic compounds have excellent properties in the fields of medicine and pesticides, such as low dosage, low toxicity, high efficacy, and strong metabolic capacity, and are widely used.

Synthesis

3970-40-9

437-86-5

Cesium fluoride (97.5 g, 642 mmol) was added to a solution of 2-chloro-1-methyl-3-nitrobenzene (73.4 g, 428 mmol) in dimethyl sulfoxide (DMSO, 185 mL) under nitrogen protection. The reaction mixture was stirred at 140 °C for 10 hours. Upon completion of the reaction, the mixture was slowly poured into 0.5 N hydrochloric acid and extracted twice with ethyl acetate. The organic phases were combined, washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by reduced pressure distillation (boiling point: 118-122 °C/15 mmHg) to give 2-fluoro-3-nitrotoluene (54.4 g, 82% yield) as a yellow oil.1H NMR (DMSO-d6, 270 MHz) δ (ppm): 7.96 (m, 1H), 7.73 (m, 1H), 7.34 (t, J = 8.2 Hz, 1H), 2.35 (t, J = 8.2 Hz, 1H), 2.35 (t, J = 8.2 Hz, 1H), 2.35 (t, J = 8.2 Hz, 1H). 1H), 2.35 (d, J = 2.4 Hz, 3H). Intersil C18 (ODS, 5 μm, 4.6 mm ID × 50 mm, GL Sciences) or SunFire C18 (ODS, 5 μm, 4.6 mm ID × 50 mm, Waters); mobile phases: water (A) containing 0.05% trifluoroacetic acid and acetonitrile (B) containing 0.05% trifluoroacetic acid; elution method: gradient elution ( Solvent B was raised from 10% to 95% in 3.5 min, then lowered to 10% in 1 min, holding 10% B for 0.5 min); Flow rate: 4.0 mL/min.

References

[1] Patent: EP1982982, 2008, A1. Location in patent: Page/Page column 196
[2] Patent: EP2172198, 2010, A1
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 11, p. 1059 - 1063
[4] Patent: KR101511396, 2015, B1. Location in patent: Paragraph 2861-2865

2-Fluoro-3-nitrotoluene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-3-nitrotoluene Suppliers

Americas 1 China 257 Europe 3 Germany 1 India 6 Italy 1 Japan 1 Ukraine 1 United Kingdom 13 United States 36 Global 320

Shanghai Jiahua Herong Biotechnology Co., Ltd

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Fuxin F-Block Pharmaceutical Co., Ltd.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Liaoning Tianhua Chemical Co., Ltd.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Alfa Aesar

Tel: 400-6106006
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View Lastest Price from 2-Fluoro-3-nitrotoluene manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Fluoro-3-nitrotoluene 437-86-5
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 300KG
Release date: 2024-07-26

Henan Fengda Chemical Co., Ltd

Product: 2-Fluoro-3-nitrotoluene 437-86-5
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Fluoro-3-nitrotoluene 437-86-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

437-86-5, 2-Fluoro-3-nitrotolueneRelated Search:

3-Nitrotoluene 2-Nitrotoluene 4-Nitrotoluene DINITROTOLUENE Fluorine 2,4,6-Trinitrotoluene 2,6-DIFLUORO-3-NITROBENZOIC ACID 2,6-Difluoro-3-nitrobenzonitrile 4-Fluoro-3-nitrotoluene99%,4-FLUORO-3-NITROTOLUENE,4-Fluoro-3-nitrotoluene 99% 4-BROMO-3-FLUORO-6-NITROTOLUENE,4-BROMO-5-FLUORO-2-NITROTOLUENE 3-Fluoro-2-nitrotoluene 3-Fluoro-4-nitrotoluene 99%,3-Fluoro-4-nitrotoluene, 99+%,3-FLUORO-4-NITROTOLUENE 3-FLUORO-5-NITROTOLUENE,5-FLUORO-3-NITROTOLUENE 2-AMINO-4-FLUORO-5-NITROTOLUENE 3-fluoro-5-nitrobenzene 2-FLUORO-6-NITROTOLUENE,2-Fluoro-6-nitrotoluene98%,2-Fluoro-6-nitrotoluene 98% 4-Fluoro-2-nitrotoluene 98%,4-FLUORO-2-NITROTOLUENE,4-Fluoro-2-nitrotoluene98% 2-Fluoro-5-nitrotoluene 98%,2-FLUORO-5-NITROTOLUENE 98% (GC),2-Fluoro-5-nitrotoluene98%,2-FLUORO-5-NITROTOLUENE

2-FLUORO-3-NITROTOLUENE

2-Fluoro-3-nitrotluene

2-fluoro-3-Nitrotoluol

2-Fluoro-3-methylnitrobenzene, 2-Fluoro-1-methyl-3-nitrobenzene

2-Fluoro-3-maethylnitrobenzene

2-FLUORO-1-METHYL-3-NITROBENZENE

2-fluoro-3-methylnitrobenzene

2-Fluoro-3-nitrotoluene&gt

Benzene, 2-fluoro-1-methyl-3-nitro-

2-Fluoro-1-methyl-3-nitrobenzece

2-Fluoro-3-nitrotoluen

437-86-5

Aromatic Hydrocarbons (substituted) & Derivatives

Fluorinated benzene series

Fluorin-contained toluene series

Halogen toluene