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2-Amino-6-fluorobenzoic acid

Product Name
2-Amino-6-fluorobenzoic acid
CAS No.
434-76-4
Chemical Name
2-Amino-6-fluorobenzoic acid
Synonyms
6-FABA;BUTTPARK 44\01-59;TIMTEC-BB SBB006549;RARECHEM AL BO 0279;2-Amino-6-Fluorobenzoic;6-FLUOROANTHRANILIC ACID;2-amino-6-fluorobenzoate;6-FluoroanthranilicAcid>2-aMino-6-flourobenzoicacid;2-AMINO-6-FLUOROBENZOIC ACID
CBNumber
CB4351052
Molecular Formula
C7H6FNO2
Formula Weight
155.13
MOL File
434-76-4.mol
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2-Amino-6-fluorobenzoic acid Property

Melting point:
167-169 °C (lit.)
Boiling point:
223.67°C (rough estimate)
Density 
1.3021 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
pka
4.01±0.10(Predicted)
form 
Crystalline Powder
color 
Yellow to brown
BRN 
3540926
InChIKey
RWSFZKWMVWPDGZ-UHFFFAOYSA-N
CAS DataBase Reference
434-76-4(CAS DataBase Reference)
NIST Chemistry Reference
Anthralic acid, 6-fluoro-(434-76-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
443026
Product name
2-Amino-6-fluorobenzoic acid
Purity
98%
Packaging
5g
Price
$30.8
Updated
2023/01/07
TCI Chemical
Product number
F0475
Product name
6-Fluoroanthranilic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
F0475
Product name
6-Fluoroanthranilic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$87
Updated
2024/03/01
Alfa Aesar
Product number
A10919
Product name
2-Amino-6-fluorobenzoic acid, 98%
Packaging
1g
Price
$34.65
Updated
2024/03/01
Alfa Aesar
Product number
A10919
Product name
2-Amino-6-fluorobenzoic acid, 98%
Packaging
5g
Price
$114.65
Updated
2024/03/01
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2-Amino-6-fluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Used in the synthesis of a novel benzamide with potent neuroleptic activity. 5- fluoro-2-methyl-3,l-benzoxazin-4-one was obtained from 2-amino-6-fluorobenzoic acid. The condensation of 2-amino-6-fluorobenzoic acid methyl ester and (4-fluorophenyl) acetyl chloride with N,N-dimethylamino-4-pyridine in CH 2 Cl 2 to give 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester in 61% yield. 2 Amino 6 fluorobenzoic acid is another easily ac cessible synthon for construction of monofluorinated heterocycles. Reactions of 2,3,4,6-tetra-O-acetyl-n-D_glucopyranosyl bromide (2) with p-hydroxybenzaldehyde, trifluoromethyl and fluoro substi- tuted aniline and 2-amino-6-fluorobenzoic acid gave lO-(Pformyl- pheny1)-2,3,4,6-tetra-O-acetyl-(3-D-glucopyranoside. 2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material.

Definition

ChEBI: 2-Amino-6-fluorobenzoic acid is an aminobenzoic acid.

storage

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Synthesis

The synthesis of 2-Amino-6-fluorobenzoic acid is as follows:
A 50 ml three-necked flask was charged with 1.85 g (10 mmol) of 6-fluoro-2-nitrobenzoic acid, 25.6 mg (0.2 mmol) of molybdenum dioxide, and 76.8 mg of activated carbon. 30 ml of absolute ethanol was added dropwise 1.25 g (20 mmol) of hydrazine hydrate (80%) at room temperature. After the reaction was completed at room temperature for 7 h, TLC monitoring showed that the reaction was completed, filtered, and the filtrate was concentrated, then ethyl acetate (20 mL) and water (10 ml) were added and extracted. The organic phase was washed with water and concentrated to give 1.5g desired product as a pale yellow solid, yield 96.8%, HPLC purity 99.6%.

2-Amino-6-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-6-fluorobenzoic acid Suppliers

Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
21-31038972 15721252604
Fax
+86-21-51385350
Email
ammyzuo@harvest-chem.com
Country
China
ProdList
2510
Advantage
64
Tianjin Jinyuda Chemical Co., Ltd.
Tel
022-58013646 13011382049
Email
sales@jinyudachem.com
Country
China
ProdList
1882
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2883
Advantage
65
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View Lastest Price from 2-Amino-6-fluorobenzoic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-6-fluorobenzoic acid 434-76-4
Price
US $0.10/KG
Min. Order
0.1KG
Purity
98%
Supply Ability
200TONS
Release date
2019-12-24
Honest Joy Holdings Limited
Product
2-Amino-6-fluorobenzoic acid 434-76-4
Price
US $0.00/KG
Min. Order
1KG
Purity
97.4%
Supply Ability
100 tons
Release date
2022-02-20
Career Henan Chemical Co
Product
2-Amino-6-fluorobenzoic acid 434-76-4
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-20

434-76-4, 2-Amino-6-fluorobenzoic acidRelated Search:


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