4-AMINO-2-FLUOROBENZOIC ACID

Product Name: 4-AMINO-2-FLUOROBENZOIC ACID
CAS No.: 446-31-1
Chemical Name: 4-AMINO-2-FLUOROBENZOIC ACID
Synonyms: BUTTPARK 22\09-96;4-AMINO-2-FLUOROBENZ;4-Carboxy-3-fluoroaniline;2-FLUORO-4-AMINOBENZOIC ACID;4-AMINO-2-FLUOROBENZOIC ACID;4-azanyl-2-fluoro-benzoic acid;Benzoic acid, 4-amino-2-fluoro-;4-AMINO-2-FLUOROBENZENECARBOXYLIC ACID;4-AMINO-2-FLUOROBENZOIC ACID USP/EP/BP;4-Amino-2-Fluorobenzoic Acid 2-Fluoro-4-Aminobenzoic Acid
CBNumber: CB2194129
Molecular Formula: C7H6FNO2
Formula Weight: 155.13
MOL File: 446-31-1.mol

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4-AMINO-2-FLUOROBENZOIC ACID Property

Melting point:: 210 °C (dec.)
Boiling point:: 336.1±27.0 °C(Predicted)
Density: 1.430±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to crystal
pka: 3.93±0.10(Predicted)
color: White to Orange to Green
InChI: InChI=1S/C7H6FNO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,9H2,(H,10,11)
InChIKey: QHERSCUZBKDVOC-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(N)C=C1F
CAS DataBase Reference: 446-31-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 650625
Product name: 4-Amino-2-fluorobenzoic acid
Purity: 97%
Packaging: 250mg
Price: $73.7
Updated: 2023/06/20

Sigma-Aldrich

Product number: 650625
Product name: 4-Amino-2-fluorobenzoic acid
Purity: 97%
Packaging: 1g
Price: $108
Updated: 2023/06/20

TCI Chemical

Product number: A3164
Product name: 4-Amino-2-fluorobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $92
Updated: 2025/07/31

TCI Chemical

Product number: A3164
Product name: 4-Amino-2-fluorobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $365
Updated: 2025/07/31

TRC

Product number: A634698
Product name: 4-Amino-2-fluorobenzoic Acid
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

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4-AMINO-2-FLUOROBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

mp 216- 216.5°C

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

403-24-7

446-31-1

2-Fluoro-4-nitrobenzoic acid (1.0 g, 5.4 mmol) was used as a raw material and dissolved in 20 mL of a solvent mixture of acetic acid and methanol (1:1, v/v). A catalytic amount of palladium carbon (25 mg) was added and the reaction was stirred overnight at room temperature under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. Subsequently, the solvent was removed by distillation under reduced pressure to afford 4-amino-2-fluorobenzoic acid (0.86 g, 100% yield) as a cream colored solid.

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 27, p. 6730 - 6739
[2] Patent: WO2004/11460, 2004, A2. Location in patent: Page 57
[3] Patent: WO2010/132615, 2010, A1. Location in patent: Page/Page column 133
[4] Journal of the American Chemical Society, 1944, vol. 66, p. 1631
[5] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2697 - 2706

4-AMINO-2-FLUOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-2-FLUOROBENZOIC ACID Suppliers

Americas 1 Belgium 1 Canada 1 China 204 Europe 1 France 2 Germany 5 India 7 Italy 1 Japan 1 Switzerland 2 United Kingdom 19 United States 45 Global 290

Tianjin Ruide Famo Technology Co., Ltd

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INTATRADE GmbH

Tel: +49 3493/605464
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Energy Chemical

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View Lastest Price from 4-AMINO-2-FLUOROBENZOIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-AMINO-2-FLUOROBENZOIC ACID 446-31-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-29

Career Henan Chemical Co

Product: 4-AMINO-2-FLUOROBENZOIC ACID 446-31-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-31

446-31-1, 4-AMINO-2-FLUOROBENZOIC ACIDRelated Search:

2-Fluoro-4-nitrobenzoic acid 2-Fluorobenzoic acid 4-Bromo-2-fluoro-N-methylbenzamide 4-BROMO-2-FLUOROBENZAMIDE 4-amino-2-fluoro-N-methylbenzamide 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- Enzalutamide Impurity 7 Benzoic acid, 4-isothiocyanato-2-(trifluoromethyl)- 2-FLUORO-N-METHYL-4-NITROBENZAMIDE 4-Amino-2-(trifluoromethyl)benzamide 4-NITRO-2-(TRIFLUOROMETHYL)BENZONITRILE 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 1 Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-5,5-dimethyl-4-oxo-1-imidazolidinyl]-2-fluoro-N-methyl- Benzamide, 4-amino-2-fluoro- (9CI) 4-Amino-2-fluoro-N,N-dimethylbenzamide 4-AMINO-2-TRIFLUOROMETHYLBENZOIC ACID METHYL 2-FLUORO-4-NITROBENZENECARBOXYLATE

2-FLUORO-4-AMINOBENZOIC ACID

BUTTPARK 22\09-96

4-AMINO-2-FLUOROBENZENECARBOXYLIC ACID

4-AMINO-2-FLUOROBENZOIC ACID

4-azanyl-2-fluoro-benzoic acid

4-AMINO-2-FLUOROBENZ

4-Carboxy-3-fluoroaniline

Benzoic acid, 4-amino-2-fluoro-

4-Amino-2-Fluorobenzoic Acid 2-Fluoro-4-Aminobenzoic Acid

4-AMINO-2-FLUOROBENZOIC ACID USP/EP/BP

446-31-1

Aromatic Amino Acids

Specialty Synthesis

Unnatural Amino Acid Derivatives

Peptide Synthesis

Fluorine series

Fluorin-contained Benzoic acid series

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Aromatic Amino Acids

Peptide Synthesis

Unnatural Amino Acid Derivatives

intermediate