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4-amino-2-fluoro-N-methylbenzamide

Product Name
4-amino-2-fluoro-N-methylbenzamide
CAS No.
915087-25-1
Chemical Name
4-amino-2-fluoro-N-methylbenzamide
Synonyms
N-Methyl-2-fluoro-4-aminobenzamide;N-Methyl-4-amino-2-fluoro-benzamide;Enzalutamide ITS-3;Enzalutamide Impurity 40;Enzalutamide Impurity 20;4-AMINO-2-FLUORO-N-METHYLBENZAMIDE;4-amino-2-fluoro-N-menthylbenzamide;N-Methyl-2-fluoro-4-AminobenzoylAmine;2. 4-aMino-2-fluoro-N-MethylbenzaMide;BenzaMide, 4-aMino-2-fluoro-N-Methyl-
CBNumber
CB02452656
Molecular Formula
C8H9FN2O
Formula Weight
168.17
MOL File
915087-25-1.mol
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4-amino-2-fluoro-N-methylbenzamide Property

Melting point:
160 - 163°C
Boiling point:
320℃
Density 
1.234
Flash point:
147℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.12±0.46(Predicted)
color 
White to Off-White
Stability:
Moisture Sensitive
InChI
InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12)
InChIKey
XOKAXPQJUODMSH-UHFFFAOYSA-N
SMILES
C(NC)(=O)C1=CC=C(N)C=C1F
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Signal word
Warning
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N-Bromosuccinimide Price

TRC
Product number
A609743
Product name
4-​Amino-​2-​fluoro-​N-​methylbenzamide
Packaging
25g
Price
$275
Updated
2021/12/16
TRC
Product number
A609743
Product name
4-​Amino-​2-​fluoro-​N-​methylbenzamide
Packaging
50g
Price
$520
Updated
2021/12/16
AK Scientific
Product number
J95296
Product name
4-Amino-2-fluoro-N-methylbenzamide
Packaging
100g
Price
$520
Updated
2021/12/16
Matrix Scientific
Product number
143913
Product name
4-Amino-2-fluoro-N-methylbenzamide
Purity
95%
Packaging
25g
Price
$1110
Updated
2021/12/16
Matrix Scientific
Product number
143913
Product name
4-Amino-2-fluoro-N-methylbenzamide
Purity
95%
Packaging
5g
Price
$370
Updated
2021/12/16
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4-amino-2-fluoro-N-methylbenzamide Chemical Properties,Usage,Production

Uses

4-amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors.

Description

4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.

Preparation

2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare 4-amino-2-fluoro-N-methylbenzamide.

4-amino-2-fluoro-N-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-amino-2-fluoro-N-methylbenzamide Suppliers

Haohong (Qihe) Medical Technology Co., LTD
Tel
18068541569 18660163165
Fax
0519-85551569
Email
sale@inyelchem.com
Country
China
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194
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Beijing Sai Siyuan Biomedical Technology Co., Ltd.
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010-87925700 13522399152
Email
1664478984@qq.com
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China
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10
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58
Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375887 13596650888
Email
3385307203@qq.com
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China
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294
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Chemvon Biotechnology Co., Ltd
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021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
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China
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371
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ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
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822
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
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9551
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Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
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China
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Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
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Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9816
Advantage
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View Lastest Price from 4-amino-2-fluoro-N-methylbenzamide manufacturers

Wuhan Cell Pharmaceutical Co., Ltd
Product
4-AMINO-2-FLUORO-N-METHYLBENZAMIDE 915087-25-1
Price
US $9.90-454.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2023-03-30
Anhui Dexinjia Biopharm Co., Ltd
Product
N-Methyl-2-fluoro-4-aminobenzamide 915087-25-1
Price
US $15.00-50.00/kg
Min. Order
1kg
Purity
NLT98%
Supply Ability
5 ton per month
Release date
2023-09-19
Shanghai Joiny Pharmaceutical Co.,LTD
Product
N-Methyl-2-fluoro-4-aminobenzamide 915087-25-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
5500kg
Release date
2023-09-12