4-amino-2-fluoro-N-methylbenzamide

Product Name: 4-amino-2-fluoro-N-methylbenzamide
CAS No.: 915087-25-1
Chemical Name: 4-amino-2-fluoro-N-methylbenzamide
Synonyms: N-Methyl-2-fluoro-4-aminobenzamide;N-Methyl-4-amino-2-fluoro-benzamide;Enzalutamide ITS-3;Enzalutamide Impurity 40;Enzalutamide Impurity 20;4-AMINO-2-FLUORO-N-METHYLBENZAMIDE;4-amino-2-fluoro-N-menthylbenzamide;N-Methyl-2-fluoro-4-AminobenzoylAmine;2. 4-aMino-2-fluoro-N-MethylbenzaMide;BenzaMide, 4-aMino-2-fluoro-N-Methyl-
CBNumber: CB02452656
Molecular Formula: C8H9FN2O
Formula Weight: 168.17
MOL File: 915087-25-1.mol

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4-amino-2-fluoro-N-methylbenzamide Property

Melting point:: 160 - 163°C
Boiling point:: 320℃
Density: 1.234
Flash point:: 147℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.12±0.46(Predicted)
color: White to Off-White
Stability:: Moisture Sensitive
InChI: InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12)
InChIKey: XOKAXPQJUODMSH-UHFFFAOYSA-N
SMILES: C(NC)(=O)C1=CC=C(N)C=C1F

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A609743
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Packaging: 25g
Price: $275
Updated: 2021/12/16

TRC

Product number: A609743
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Packaging: 50g
Price: $520
Updated: 2021/12/16

AK Scientific

Product number: J95296
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Packaging: 100g
Price: $520
Updated: 2021/12/16

Matrix Scientific

Product number: 143913
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Purity: 95%
Packaging: 25g
Price: $1110
Updated: 2021/12/16

Matrix Scientific

Product number: 143913
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Purity: 95%
Packaging: 5g
Price: $370
Updated: 2021/12/16

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4-amino-2-fluoro-N-methylbenzamide Chemical Properties,Usage,Production

Uses

4-amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors.

Description

4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.

Preparation

2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare 4-amino-2-fluoro-N-methylbenzamide.

Synthesis

956104-46-4

915087-25-1

General procedure for the synthesis of N-methyl-2-fluoro-4-aminobenzamide from the compound (CAS: 956104-46-4): Trifluoroacetic acid (TFA, 1 mL) was slowly added dropwise to a solution of 4-methylamino-2-fluorobenzyl amide (60 mg, 0.21 mmol) in anhydrous dichloromethane (DCM, 0.5 mL), under protection of argon gas. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporator and the residue was purified by silica gel fast column chromatography (eluent: hexane/ethyl acetate) to quantitatively obtain the target product, N-methyl-2-fluoro-4-aminobenzamide. The product structure was confirmed by 1H NMR (500 MHz, CDCl3) and 13C NMR (500 MHz, CDCl3): 1H NMR δ 2.98 (d, J = 4.8 Hz, 3H), 4.15 (br s, 2H), 6.32 (d, J = 14.3 Hz, 1H), 6.48 (d, J = 8.2 Hz, 1H), 6.61 ( br s, 1H), 7.90 (dd, J = 8.6 Hz, 1H); 13C NMR δ 26.63, 100.8 (d, J = 28.8 Hz), 110.3 (d, J = 244.6 Hz), 110.9, 133.3 (d, J = 4.3 Hz), 151.4 (d, J = 12.5 Hz), 162.2 (d, J = 244.6 Hz), 164.3 (d, J = 3.5 Hz).

References

[1] Patent: WO2008/119015, 2008, A2. Location in patent: Page/Page column 52-53
[2] Patent: US9388159, 2016, B2. Location in patent: Page/Page column 21; 22

4-amino-2-fluoro-N-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-amino-2-fluoro-N-methylbenzamide Suppliers

Canada 1 China 230 India 14 Ukraine 1 United States 6 Global 252

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View Lastest Price from 4-amino-2-fluoro-N-methylbenzamide manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 4-Amino-2-fluoro-N-methylbenzamide. 915087-25-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-29

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 4-amino-2-fluoro-N-methylbenzamide 915087-25-1
Price: US $990.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-19

Hebei Junhua Import and Export Co., LTD

Product: 4-amino-2-fluoro-N-methylbenzamide 915087-25-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2025-03-21

915087-25-1, 4-amino-2-fluoro-N-methylbenzamideRelated Search:

4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 2-FLUORO-N-METHYL-4-NITROBENZAMIDE Enzalutamide Impurity 7 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 7 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- [2H6]-Enzalutamide N-desMethyl EnzalutaMide Enzalutamide carboxylic acid Methyl 4-bromo-2-fluorobenzoate Enzalutamide 4-[3-[4-Cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-(Methyl-d3)benzaMide 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide 4-Bromo-2-fluorobenzoic acid methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate EnzalutaMide IMpurity Enzalutamide 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzoic acid methyl ester

4-AMINO-2-FLUORO-N-METHYLBENZAMIDE

N-Methyl-2-fluoro-4-aminobenzamide

BenzaMide, 4-aMino-2-fluoro-N-Methyl-

2. 4-aMino-2-fluoro-N-MethylbenzaMide

N-Methyl-4-amino-2-fluoro-benzamide

4-amino-2-fluoro-N-menthylbenzamide

Enzalutamide Impurity 20

Enzalutamide ITS-3

N-Methyl-2-fluoro-4-AminobenzoylAmine

Enzalutamide Impurity 40

4-amino-2-fluoro-n-methylbenzamide HPLC 98%

915087-25-1