Methyl 4-bromo-2-fluorobenzoate

Product Name: Methyl 4-bromo-2-fluorobenzoate
CAS No.: 179232-29-2
Chemical Name: Methyl 4-bromo-2-fluorobenzoate
Synonyms: Fluoro-4-bromobenzoate;Enzalutamide Impurity 15;Enzalutamide ImpuritiesC;Enzalutamide EP Impurity C;Methy 4-bromo-2-fluorobenzoate;Methyl 4-bromo-2-fluorobenzoate;Methyl 2-fluoro-4-bromobenzoate;Methyl 4-bromo-2-fluorobenzoate, 98%;4-BROMO-2-FLUOROBENZOIC ACID METHYL ESTER;2-Fluoro-4-bromobenzoic acid methyl ester
CBNumber: CB61457618
Molecular Formula: C8H6BrFO2
Formula Weight: 233.03
MOL File: 179232-29-2.mol

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Methyl 4-bromo-2-fluorobenzoate Property

Melting point:: 58-60℃
Boiling point:: 272.7±25.0℃ (760 Torr)
Density: 1.577±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 118.7±23.2℃
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C8H6BrFO2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3
InChIKey: DLILIUSWDLJMCE-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(Br)C=C1F

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3229
Product name: Methyl 4-Bromo-2-fluorobenzoate
Packaging: 5G
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: M3229
Product name: Methyl 4-Bromo-2-fluorobenzoate
Packaging: 25G
Price: $209
Updated: 2025/07/31

TRC

Product number: B683335
Product name: 4-Bromo-2-fluorobenzoicAcidMethylEster
Packaging: 25g
Price: $165
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2623-B-15
Product name: Methyl 4-bromo-2-fluorobenzoate
Packaging: 5G
Price: $175
Updated: 2021/12/16

Apolloscientific

Product number: PC200410
Product name: Methyl 4-Bromo-2-fluorobenzoate
Packaging: 25g
Price: $119
Updated: 2021/12/16

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Methyl 4-bromo-2-fluorobenzoate Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

4-Bromo-2-fluorobenzoic Acid Methyl Ester is the methyl ester derivative of 4-Bromo-2-fluorobenzoic Acid (B684620) and is used as a reagent in the synthesis of aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-Chagas agents.

Synthesis

67-56-1

112704-79-7

179232-29-2

Step 1: To a stirred solution of 4-bromo-2-fluorobenzoic acid (15.0 g, 68.49 mmol, 1 eq.) in methanol (150 mL) was slowly added thionyl chloride (23.09 mL, 136.9 mmol, 2 eq.) at 0 °C. The reaction mixture was kept at 0 °C for 15 minutes before being brought to room temperature and stirring was continued for 12 hours. After completion of the reaction, methanol was removed by evaporation under reduced pressure and the residue was diluted with ethyl acetate (250 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate solution, brine (150 mL) and deionized water (150 mL). The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 4-bromo-2-fluorobenzoate (15 g, 93% yield) as an off-white solid (LC-MS purity 99%; TLC conditions: ethyl acetate/petroleum ether (3:7), Rf value 0.8).

References

[1] Patent: WO2004/46096, 2004, A2. Location in patent: Page 38
[2] Organic Process Research and Development, 2011, vol. 15, # 3, p. 565 - 569
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 19, p. 7651 - 7668
[4] Patent: WO2015/48306, 2015, A1. Location in patent: Page/Page column 88; 112
[5] Patent: WO2013/68461, 2013, A1. Location in patent: Page/Page column 105; 106; 109

Methyl 4-bromo-2-fluorobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-bromo-2-fluorobenzoate Suppliers

Americas 1 China 218 Europe 1 India 12 Japan 1 Switzerland 1 United Kingdom 4 United States 17 Global 255

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View Lastest Price from Methyl 4-bromo-2-fluorobenzoate manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: Ethyl 2-fluoro-3-oxopentanoate 179232-29-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20000kgs
Release date: 2025-10-22

Shaanxi Dideu New Materials Co. Ltd

Product: Methyl 4-bromo-2-fluorobenzoate 179232-29-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-06

Career Henan Chemical Co

Product: Methyl 4-bromo-2-fluorobenzoate 179232-29-2
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2018-12-24

179232-29-2, Methyl 4-bromo-2-fluorobenzoateRelated Search:

Methyl 4-bromo-3-methylbenzoate 4-Bromo-2-fluorobenzoic acid 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 7 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- 4-amino-2-fluoro-N-methylbenzamide 4-Bromo-2-fluoro-N-methylbenzamide Enzalutamide Impurity 7 [2H6]-Enzalutamide N-desMethyl EnzalutaMide Enzalutamide carboxylic acid 4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE Enzalutamide 4-[3-[4-Cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-(Methyl-d3)benzaMide 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate EnzalutaMide IMpurity Enzalutamide

Methyl 4-bromo-2-fluorobenzoate

Fluoro-4-bromobenzoate

4-BROMO-2-FLUOROBENZOIC ACID METHYL ESTER

Methyl 2-fluoro-4-bromobenzoate

Enzalutamide Impurity 15

Enzalutamide EP Impurity C

2-Fluoro-4-bromobenzoic acid methyl ester

Benzoic acid, 4-bromo-2-fluoro-, methyl ester

Methyl 4-bromo-2-fluorobenzoate(For export only)

Methy 4-bromo-2-fluorobenzoate

Enzalutamide ImpuritiesC

Methyl 4-bromo-2-fluorobenzoate, 98%

179232-29-2

Aromatic Esters

blocks

Bromides

Carboxes

FluoroCompounds