Methyl 4-bromo-3-methylbenzoate
- Product Name
- Methyl 4-bromo-3-methylbenzoate
- CAS No.
- 148547-19-7
- Chemical Name
- Methyl 4-bromo-3-methylbenzoate
- Synonyms
- Methyl 4-bromo-3-met;METHYL 4-BROMO-M-TOLUATE;Methyl 4-bromo-3-methylbe;methyl 4-bromo-3-methylbenzoat;Methyle4-bromo-3-methylbenzoate;METHYL 4-BROMO-3-METHYLBENZOATE;Methyl4-Bromo-3-methylbenzoate>Methyl 4-Bromo-3-Methoxynicotinate;2-Bromo-5-(methoxycarbonyl)toluene;4-BROMO-M-TOLUIC ACID METHYL ESTER
- CBNumber
- CB1724372
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 148547-19-7.mol
Methyl 4-bromo-3-methylbenzoate Property
- Melting point:
- 38-44 °C (lit.)
- Boiling point:
- 287.4±20.0 °C(Predicted)
- Density
- 1.433±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- Low Melting Solid or Liquid
- color
- White to yellow
- BRN
- 6593534
- InChI
- InChI=1S/C9H9BrO2/c1-6-5-7(9(11)12-2)3-4-8(6)10/h3-5H,1-2H3
- InChIKey
- GTZTYNPAPQKIIR-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(Br)C(C)=C1
- CAS DataBase Reference
- 148547-19-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 532878
- Product name
- Methyl 4-bromo-3-methylbenzoate
- Purity
- 95%
- Packaging
- 25g
- Price
- $103
- Updated
- 2025/07/31
- Product number
- B2256
- Product name
- Methyl 4-Bromo-3-methylbenzoate
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- B2256
- Product name
- Methyl 4-Bromo-3-methylbenzoate
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $131
- Updated
- 2025/07/31
- Product number
- 455473
- Product name
- Methyl 4-bromo-3-methylbenzoate
- Packaging
- 500mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- M296175
- Product name
- Methyl 4-bromo-3-methylbenzoate
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
Methyl 4-bromo-3-methylbenzoate Chemical Properties,Usage,Production
Chemical Properties
Colorless low melting solid
Uses
Methyl 4-bromo-3-methylbenzoate may be used in the preparation of:
- 4-bromo-3-vinylbenzoic acid
- 4-bromo-3-(methylphenyl)methanol
- methyl (E)-4-bromo-3-[(phenylmethoxyimino)methyl]benzoate
It may be used as a starting material in the total synthesis of (-)-martinellic acid.
General Description
Methyl 4-bromo-3-methylbenzoate, an aromatic ester, undergoes Suzuki coupling with 2-chloroboronic acid to afford the corresponding biaryl.
Synthesis
67-56-1
7697-28-1
148547-19-7
To a concentrated solution of 4-bromo-3-methylbenzoic acid (3 g, 13.19 mmol) in methanol (15 ml) was added concentrated sulfuric acid (catalytic amount). The reaction mixture was heated to reflux for 14 hours and subsequently cooled to 0°C. The reaction mixture was neutralized with saturated sodium bicarbonate solution and the precipitated solid product was collected by filtration. The crude product was purified by silica gel column chromatography to afford methyl 4-bromo-3-methylbenzoate (3.1 g, 97% yield) as a white solid.
References
[1] Patent: US2011/71150, 2011, A1. Location in patent: Page/Page column 33
[2] Angewandte Chemie - International Edition, 2008, vol. 47, # 44, p. 8482 - 8486
[3] Patent: WO2006/110173, 2006, A2. Location in patent: Page/Page column 78
[4] Chemical Communications, 2018, vol. 54, # 65, p. 9051 - 9054
[5] Patent: US2013/131016, 2013, A1. Location in patent: Paragraph 0189
Methyl 4-bromo-3-methylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 4-bromo-3-methylbenzoate manufacturers
- Product
- Methyl 4-bromo-3-methylbenzoate 148547-19-7
- Price
- US $2310.60-4393.90/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2018-08-03