ChemicalBook > CAS DataBase List > Methyl 4-bromo-3-methylbenzoate

Methyl 4-bromo-3-methylbenzoate

Product Name: Methyl 4-bromo-3-methylbenzoate
CAS No.: 148547-19-7
Chemical Name: Methyl 4-bromo-3-methylbenzoate
Synonyms: Methyl 4-bromo-3-met;METHYL 4-BROMO-M-TOLUATE;Methyl 4-bromo-3-methylbe;methyl 4-bromo-3-methylbenzoat;Methyle4-bromo-3-methylbenzoate;METHYL 4-BROMO-3-METHYLBENZOATE;Methyl4-Bromo-3-methylbenzoate>Methyl 4-Bromo-3-Methoxynicotinate;2-Bromo-5-(methoxycarbonyl)toluene;4-BROMO-M-TOLUIC ACID METHYL ESTER
CBNumber: CB1724372
Molecular Formula: C9H9BrO2
Formula Weight: 229.07
MOL File: 148547-19-7.mol

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Methyl 4-bromo-3-methylbenzoate Property

Melting point:: 38-44 °C (lit.)
Boiling point:: 287.4±20.0 °C(Predicted)
Density: 1.433±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Low Melting Solid or Liquid
color: White to yellow
BRN: 6593534
InChI: InChI=1S/C9H9BrO2/c1-6-5-7(9(11)12-2)3-4-8(6)10/h3-5H,1-2H3
InChIKey: GTZTYNPAPQKIIR-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(Br)C(C)=C1
CAS DataBase Reference: 148547-19-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 532878
Product name: Methyl 4-bromo-3-methylbenzoate
Purity: 95%
Packaging: 25g
Price: $103
Updated: 2025/07/31

TCI Chemical

Product number: B2256
Product name: Methyl 4-Bromo-3-methylbenzoate
Purity: >97.0%(GC)
Packaging: 5g
Price: $35
Updated: 2025/07/31

TCI Chemical

Product number: B2256
Product name: Methyl 4-Bromo-3-methylbenzoate
Purity: >97.0%(GC)
Packaging: 25g
Price: $131
Updated: 2025/07/31

TRC

Product number: M296175
Product name: Methyl 4-bromo-3-methylbenzoate
Packaging: 1g
Price: $55
Updated: 2021/12/16

TRC

Product number: M296175
Product name: Methyl 4-bromo-3-methylbenzoate
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

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Methyl 4-bromo-3-methylbenzoate Chemical Properties,Usage,Production

Chemical Properties

Colorless low melting solid

Uses

Methyl 4-bromo-3-methylbenzoate may be used in the preparation of:

4-bromo-3-vinylbenzoic acid
4-bromo-3-(methylphenyl)methanol
methyl (E)-4-bromo-3-[(phenylmethoxyimino)methyl]benzoate

It may be used as a starting material in the total synthesis of (-)-martinellic acid.

General Description

Methyl 4-bromo-3-methylbenzoate, an aromatic ester, undergoes Suzuki coupling with 2-chloroboronic acid to afford the corresponding biaryl.

Synthesis

67-56-1

7697-28-1

148547-19-7

To a concentrated solution of 4-bromo-3-methylbenzoic acid (3 g, 13.19 mmol) in methanol (15 ml) was added concentrated sulfuric acid (catalytic amount). The reaction mixture was heated to reflux for 14 hours and subsequently cooled to 0°C. The reaction mixture was neutralized with saturated sodium bicarbonate solution and the precipitated solid product was collected by filtration. The crude product was purified by silica gel column chromatography to afford methyl 4-bromo-3-methylbenzoate (3.1 g, 97% yield) as a white solid.

References

[1] Patent: US2011/71150, 2011, A1. Location in patent: Page/Page column 33
[2] Angewandte Chemie - International Edition, 2008, vol. 47, # 44, p. 8482 - 8486
[3] Patent: WO2006/110173, 2006, A2. Location in patent: Page/Page column 78
[4] Chemical Communications, 2018, vol. 54, # 65, p. 9051 - 9054
[5] Patent: US2013/131016, 2013, A1. Location in patent: Paragraph 0189

Methyl 4-bromo-3-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 4-bromo-3-methylbenzoate manufacturers

Career Henan Chemical Co

Product: Methyl 4-bromo-3-methylbenzoate 148547-19-7
Price: US $2310.60-4393.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100kg
Release date: 2018-08-03

148547-19-7, Methyl 4-bromo-3-methylbenzoateRelated Search:

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methyl 4-bromo-3-methylbenzoat

Methyl4-Bromo-3-methylbenzoate&gt

Benzoic acid, 4-bromo-3-methyl-, methyl ester

148547-19-7

148548-19-7

BrC6H3CH3CO2CH3

Esters

Organic Building Blocks

ARYL HALIDE

Building Blocks

C8 to C9

Carbonyl Compounds

blocks

Bromides

Carboxes

Aromatic Esters

Benzene series

Benzoic acid

Acids & Esters

Bromine Compounds

C8 to C9

Carbonyl Compounds

Esters

Pyridines

bc0001