4-Bromo-2-fluoro-N-methylbenzamide

Product Name: 4-Bromo-2-fluoro-N-methylbenzamide
CAS No.: 749927-69-3
Chemical Name: 4-Bromo-2-fluoro-N-methylbenzamide
Synonyms: SKL778;EZLA-ZZC-0/EZLA-S1;Enzalutamide ImpuritiesB;Enzalutamide Impurity 14;Enzalutamide Impurity 62;N-METHYL 4-BROMO-2-FLUORO;Enzalutamide EP Impurity B;4-Bromo-2-fluoro-N-methylbenzamide;N-Methyl 4-bromo-2-fluorobenzamide;EChemicalbooknzalutamideImpurity14
CBNumber: CB01457702
Molecular Formula: C8H7BrFNO
Formula Weight: 232.05
MOL File: 749927-69-3.mol

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4-Bromo-2-fluoro-N-methylbenzamide Property

Melting point:: 125.0 to 129.0 °C
Boiling point:: 284.8±30.0 °C(Predicted)
Density: 1.545±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 13.76±0.46(Predicted)
color: White to Off-White
InChIKey: BAJCFNRLEJHPTQ-UHFFFAOYSA-N
CAS DataBase Reference: 749927-69-3

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5074
Product name: 4-Bromo-2-fluoro-N-methylbenzamide
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: B5074
Product name: 4-Bromo-2-fluoro-N-methylbenzamide
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $162
Updated: 2025/07/31

TRC

Product number: B685055
Product name: 4-Bromo-2-fluoro-N-methylbenzamide
Packaging: 250mg
Price: $145
Updated: 2021/12/16

Usbiological

Product number: 161244
Product name: 4-Bromo-2-fluoro-N-methylbenzamide
Packaging: 250mg
Price: $460
Updated: 2021/12/16

TRC

Product number: B685055
Product name: 4-Bromo-2-fluoro-N-methylbenzamide
Packaging: 2.5g
Price: $1135
Updated: 2021/12/16

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4-Bromo-2-fluoro-N-methylbenzamide Chemical Properties,Usage,Production

Uses

4-Bromo-2-fluoro-N-methylbenzamide is an intermediate in the synthesis of MDV 3100 (M199800), is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex.

Synthesis

112704-79-7

74-89-5

749927-69-3

Step 1: Synthesis of 4-bromo-2-fluoro-N-methylbenzamide To a 100 mL round-bottomed flask were added 4-bromo-2-fluorobenzoic acid (3.0 g, 13.7 mmol), 2 M aqueous methylamine (34.3 mL, 68.5 mmol), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI, 6.6 g, 34.25 mmol), 1-hydroxybenzotriazole (HOBt, 2.8 g 20.6 mmol), N,N-diisopropylethylamine (DIPEA, appropriate amount) and N,N-dimethylformamide (DMF, 50 mL). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL). The aqueous phase was separated and the organic phase was extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:3, v/v) to afford the title compound 4-bromo-2-fluoro-N-methylbenzamide as a white solid (2.34 g, 74% yield). Mass spectrum (MS): [M+H]+ 232.

References

[1] Patent: CN108329236, 2018, A. Location in patent: Paragraph 0026; 0035; 0036; 0038
[2] Patent: WO2014/32498, 2014, A1. Location in patent: Page/Page column 9
[3] Patent: WO2004/74270, 2004, A2. Location in patent: Page 44
[4] Patent: US2005/176701, 2005, A1. Location in patent: Page/Page column 21
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6486 - 6489

4-Bromo-2-fluoro-N-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-fluoro-N-methylbenzamide Suppliers

Americas 1 China 279 Europe 1 France 1 Germany 3 India 15 Japan 1 Ukraine 1 United Kingdom 3 United States 16 Global 321

Jiangxi Jinfeng Pharmaceutical Co., Ltd

Tel: 793-5181188 18170363299
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Haohong (Qihe) Medical Technology Co., LTD

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Hangzhou Chemtrue Bio-Tech Co.,Ltd.

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J & K SCIENTIFIC LTD.

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View Lastest Price from 4-Bromo-2-fluoro-N-methylbenzamide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Bromo-2-fluoro-N-methylbenzamide 749927-69-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-23

Henan Fengda Chemical Co., Ltd

Product: 4-Bromo-2-fluoro-N-methylbenzamide 749927-69-3
Price: US $10.00-3.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-29

Jiangsu Boquan Biotechnology Co., Ltd.

Product: 4-Bromo-2-fluoro-N-methylbenzamide 749927-69-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-02-21

749927-69-3, 4-Bromo-2-fluoro-N-methylbenzamideRelated Search:

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4-Bromo-2-fluoro-N-methylbenzamide(For export only)

SKL778

Enzalutamide ImpuritiesB

EZLA-ZZC-0/EZLA-S1

EChemicalbooknzalutamideImpurity14

Enzalutamide Impurity 62

4-bromo-2-fluoro-N-methyl-Benzamide (Intermediate of Apalutamide)

749927-69-3

779927-69-3

blocks

Bromides

Carboxes

FluoroCompounds

Intermediate