ChemicalBook > CAS DataBase List > 4-Bromo-2-fluoro-N-methylbenzamide

4-Bromo-2-fluoro-N-methylbenzamide

Product Name
4-Bromo-2-fluoro-N-methylbenzamide
CAS No.
749927-69-3
Chemical Name
4-Bromo-2-fluoro-N-methylbenzamide
Synonyms
SKL778;EZLA-ZZC-0/EZLA-S1;Enzalutamide ImpuritiesB;Enzalutamide Impurity 14;Enzalutamide Impurity 62;N-METHYL 4-BROMO-2-FLUORO;Enzalutamide EP Impurity B;4-Bromo-2-fluoro-N-methylbenzamide;N-Methyl 4-bromo-2-fluorobenzamide;EChemicalbooknzalutamideImpurity14
CBNumber
CB01457702
Molecular Formula
C8H7BrFNO
Formula Weight
232.05
MOL File
749927-69-3.mol
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4-Bromo-2-fluoro-N-methylbenzamide Property

Melting point:
125.0 to 129.0 °C
Boiling point:
284.8±30.0 °C(Predicted)
Density 
1.545±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
13.76±0.46(Predicted)
color 
White to Off-White
InChIKey
BAJCFNRLEJHPTQ-UHFFFAOYSA-N
CAS DataBase Reference
749927-69-3
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5074
Product name
4-Bromo-2-fluoro-N-methylbenzamide
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$54
Updated
2025/07/31
TCI Chemical
Product number
B5074
Product name
4-Bromo-2-fluoro-N-methylbenzamide
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$162
Updated
2025/07/31
TRC
Product number
B685055
Product name
4-Bromo-2-fluoro-N-methylbenzamide
Packaging
250mg
Price
$145
Updated
2021/12/16
Usbiological
Product number
161244
Product name
4-Bromo-2-fluoro-N-methylbenzamide
Packaging
250mg
Price
$460
Updated
2021/12/16
TRC
Product number
B685055
Product name
4-Bromo-2-fluoro-N-methylbenzamide
Packaging
2.5g
Price
$1135
Updated
2021/12/16
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4-Bromo-2-fluoro-N-methylbenzamide Chemical Properties,Usage,Production

Uses

4-Bromo-2-fluoro-N-methylbenzamide is an intermediate in the synthesis of MDV 3100 (M199800), is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex.

Synthesis

112704-79-7

74-89-5

749927-69-3

Step 1: Synthesis of 4-bromo-2-fluoro-N-methylbenzamide To a 100 mL round-bottomed flask were added 4-bromo-2-fluorobenzoic acid (3.0 g, 13.7 mmol), 2 M aqueous methylamine (34.3 mL, 68.5 mmol), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI, 6.6 g, 34.25 mmol), 1-hydroxybenzotriazole (HOBt, 2.8 g 20.6 mmol), N,N-diisopropylethylamine (DIPEA, appropriate amount) and N,N-dimethylformamide (DMF, 50 mL). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL). The aqueous phase was separated and the organic phase was extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:3, v/v) to afford the title compound 4-bromo-2-fluoro-N-methylbenzamide as a white solid (2.34 g, 74% yield). Mass spectrum (MS): [M+H]+ 232.

References

[1] Patent: CN108329236, 2018, A. Location in patent: Paragraph 0026; 0035; 0036; 0038
[2] Patent: WO2014/32498, 2014, A1. Location in patent: Page/Page column 9
[3] Patent: WO2004/74270, 2004, A2. Location in patent: Page 44
[4] Patent: US2005/176701, 2005, A1. Location in patent: Page/Page column 21
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6486 - 6489

4-Bromo-2-fluoro-N-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromo-2-fluoro-N-methylbenzamide manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Bromo-2-fluoro-N-methylbenzamide 749927-69-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-23
Henan Fengda Chemical Co., Ltd
Product
4-Bromo-2-fluoro-N-methylbenzamide 749927-69-3
Price
US $10.00-3.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-29
Jiangsu Boquan Biotechnology Co., Ltd.
Product
4-Bromo-2-fluoro-N-methylbenzamide 749927-69-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-02-21

749927-69-3, 4-Bromo-2-fluoro-N-methylbenzamideRelated Search:

4-amino-2-fluoro-N-methylbenzamide 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- Enzalutamide Impurity 7 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 7 [2H6]-Enzalutamide N-desMethyl EnzalutaMide Enzalutamide carboxylic acid 4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE Methyl 4-bromo-2-fluorobenzoate Enzalutamide 4-[3-[4-Cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-(Methyl-d3)benzaMide 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide 4-Bromo-2-fluorobenzoic acid methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate EnzalutaMide IMpurity Enzalutamide 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzoic acid methyl ester

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