4-amino-2-fluoro-N-methylbenzamide

ChemicalBook > CAS DataBase List > 4-amino-2-fluoro-N-methylbenzamide

4-amino-2-fluoro-N-methylbenzamide

Product Name: 4-amino-2-fluoro-N-methylbenzamide
CAS No.: 915087-25-1
Chemical Name: 4-amino-2-fluoro-N-methylbenzamide
Synonyms: N-Methyl-2-fluoro-4-aminobenzamide;N-Methyl-4-amino-2-fluoro-benzamide;Enzalutamide ITS-3;Enzalutamide Impurity 40;Enzalutamide Impurity 20;4-AMINO-2-FLUORO-N-METHYLBENZAMIDE;4-amino-2-fluoro-N-menthylbenzamide;N-Methyl-2-fluoro-4-AminobenzoylAmine;2. 4-aMino-2-fluoro-N-MethylbenzaMide;BenzaMide, 4-aMino-2-fluoro-N-Methyl-
CBNumber: CB02452656
Molecular Formula: C8H9FN2O
Formula Weight: 168.17
MOL File: 915087-25-1.mol

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4-amino-2-fluoro-N-methylbenzamide Property

Melting point:: 160 - 163°C
Boiling point:: 320℃
Density: 1.234
Flash point:: 147℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.12±0.46(Predicted)
color: White to Off-White
Stability:: Moisture Sensitive
InChI: InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12)
InChIKey: XOKAXPQJUODMSH-UHFFFAOYSA-N
SMILES: C(NC)(=O)C1=CC=C(N)C=C1F

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Signal word: Warning

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N-Bromosuccinimide Price

TRC

Product number: A609743
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Packaging: 25g
Price: $275
Updated: 2021/12/16

TRC

Product number: A609743
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Packaging: 50g
Price: $520
Updated: 2021/12/16

AK Scientific

Product number: J95296
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Packaging: 100g
Price: $520
Updated: 2021/12/16

Matrix Scientific

Product number: 143913
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Purity: 95%
Packaging: 25g
Price: $1110
Updated: 2021/12/16

Matrix Scientific

Product number: 143913
Product name: 4-Amino-2-fluoro-N-methylbenzamide
Purity: 95%
Packaging: 5g
Price: $370
Updated: 2021/12/16

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4-amino-2-fluoro-N-methylbenzamide Chemical Properties,Usage,Production

Uses

4-amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors.

Description

4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.

Preparation

2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare 4-amino-2-fluoro-N-methylbenzamide.

4-amino-2-fluoro-N-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-amino-2-fluoro-N-methylbenzamide manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 4-amino-2-fluoro-N-methylbenzamide 915087-25-1
Price: US $990.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-19

Anhui Dexinjia Biopharm Co., Ltd

Product: N-Methyl-2-fluoro-4-aminobenzamide 915087-25-1
Price: US $15.00-50.00/kg
Min. Order: 1kg
Purity: NLT98%
Supply Ability: 5 ton per month
Release date: 2023-09-19

Wuhan Cell Pharmaceutical Co., Ltd

Product: 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE 915087-25-1
Price: US $9.90-454.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-03-30

915087-25-1, 4-amino-2-fluoro-N-methylbenzamideRelated Search:

4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 2-FLUORO-N-METHYL-4-NITROBENZAMIDE Enzalutamide Impurity 7 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 7 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- [2H6]-Enzalutamide N-desMethyl EnzalutaMide Enzalutamide carboxylic acid Methyl 4-bromo-2-fluorobenzoate Enzalutamide 4-[3-[4-Cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-(Methyl-d3)benzaMide 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide 4-Bromo-2-fluorobenzoic acid methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate EnzalutaMide IMpurity Enzalutamide 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzoic acid methyl ester

4-AMINO-2-FLUORO-N-METHYLBENZAMIDE

N-Methyl-2-fluoro-4-aminobenzamide

BenzaMide, 4-aMino-2-fluoro-N-Methyl-

2. 4-aMino-2-fluoro-N-MethylbenzaMide

N-Methyl-4-amino-2-fluoro-benzamide

4-amino-2-fluoro-N-menthylbenzamide

Enzalutamide Impurity 20

Enzalutamide ITS-3

N-Methyl-2-fluoro-4-AminobenzoylAmine

Enzalutamide Impurity 40

915087-25-1