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4-AMINO-2-FLUOROBENZOIC ACID

Product Name
4-AMINO-2-FLUOROBENZOIC ACID
CAS No.
446-31-1
Chemical Name
4-AMINO-2-FLUOROBENZOIC ACID
Synonyms
BUTTPARK 22\09-96;4-AMINO-2-FLUOROBENZ;4-Carboxy-3-fluoroaniline;2-FLUORO-4-AMINOBENZOIC ACID;4-AMINO-2-FLUOROBENZOIC ACID;4-azanyl-2-fluoro-benzoic acid;Benzoic acid, 4-amino-2-fluoro-;4-AMINO-2-FLUOROBENZENECARBOXYLIC ACID;4-AMINO-2-FLUOROBENZOIC ACID USP/EP/BP;4-Amino-2-Fluorobenzoic Acid 2-Fluoro-4-Aminobenzoic Acid
CBNumber
CB2194129
Molecular Formula
C7H6FNO2
Formula Weight
155.13
MOL File
446-31-1.mol
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4-AMINO-2-FLUOROBENZOIC ACID Property

Melting point:
210 °C (dec.)
Boiling point:
336.1±27.0 °C(Predicted)
Density 
1.430±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
3.93±0.10(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C7H6FNO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,9H2,(H,10,11)
InChIKey
QHERSCUZBKDVOC-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(N)C=C1F
CAS DataBase Reference
446-31-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
650625
Product name
4-Amino-2-fluorobenzoic acid
Purity
97%
Packaging
250mg
Price
$73.7
Updated
2023/06/20
Sigma-Aldrich
Product number
650625
Product name
4-Amino-2-fluorobenzoic acid
Purity
97%
Packaging
1g
Price
$108
Updated
2023/06/20
TCI Chemical
Product number
A3164
Product name
4-Amino-2-fluorobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$92
Updated
2025/07/31
TCI Chemical
Product number
A3164
Product name
4-Amino-2-fluorobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$365
Updated
2025/07/31
TRC
Product number
A634698
Product name
4-Amino-2-fluorobenzoic Acid
Packaging
2.5g
Price
$75
Updated
2021/12/16
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4-AMINO-2-FLUOROBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

mp 216- 216.5°C

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

403-24-7

446-31-1

2-Fluoro-4-nitrobenzoic acid (1.0 g, 5.4 mmol) was used as a raw material and dissolved in 20 mL of a solvent mixture of acetic acid and methanol (1:1, v/v). A catalytic amount of palladium carbon (25 mg) was added and the reaction was stirred overnight at room temperature under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. Subsequently, the solvent was removed by distillation under reduced pressure to afford 4-amino-2-fluorobenzoic acid (0.86 g, 100% yield) as a cream colored solid.

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 27, p. 6730 - 6739
[2] Patent: WO2004/11460, 2004, A2. Location in patent: Page 57
[3] Patent: WO2010/132615, 2010, A1. Location in patent: Page/Page column 133
[4] Journal of the American Chemical Society, 1944, vol. 66, p. 1631
[5] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2697 - 2706

4-AMINO-2-FLUOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-2-FLUOROBENZOIC ACID Suppliers

Americas 1 Belgium 1 Canada 1 China 204 Europe 1 France 2 Germany 5 India 7 Italy 1 Japan 1 Switzerland 2 United Kingdom 19 United States 45 Global 290
AB Chemicals Inc.
Tel
--
Fax
--
Email
sales@abcheminc.com
Country
Canada
ProdList
1128
Advantage
47
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View Lastest Price from 4-AMINO-2-FLUOROBENZOIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-AMINO-2-FLUOROBENZOIC ACID 446-31-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-29
Career Henan Chemical Co
Product
4-AMINO-2-FLUOROBENZOIC ACID 446-31-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2019-12-31

446-31-1, 4-AMINO-2-FLUOROBENZOIC ACIDRelated Search:

2-Fluoro-4-nitrobenzoic acid 2-Fluorobenzoic acid 4-Bromo-2-fluoro-N-methylbenzamide 4-BROMO-2-FLUOROBENZAMIDE 4-amino-2-fluoro-N-methylbenzamide 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- Enzalutamide Impurity 7 Benzoic acid, 4-isothiocyanato-2-(trifluoromethyl)- 2-FLUORO-N-METHYL-4-NITROBENZAMIDE 4-Amino-2-(trifluoromethyl)benzamide 4-NITRO-2-(TRIFLUOROMETHYL)BENZONITRILE 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 1 Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-5,5-dimethyl-4-oxo-1-imidazolidinyl]-2-fluoro-N-methyl- Benzamide, 4-amino-2-fluoro- (9CI) 4-Amino-2-fluoro-N,N-dimethylbenzamide 4-AMINO-2-TRIFLUOROMETHYLBENZOIC ACID METHYL 2-FLUORO-4-NITROBENZENECARBOXYLATE

  • 2-FLUORO-4-AMINOBENZOIC ACID
  • BUTTPARK 22\09-96
  • 4-AMINO-2-FLUOROBENZENECARBOXYLIC ACID
  • 4-AMINO-2-FLUOROBENZOIC ACID
  • 4-azanyl-2-fluoro-benzoic acid
  • 4-AMINO-2-FLUOROBENZ
  • 4-Carboxy-3-fluoroaniline
  • Benzoic acid, 4-amino-2-fluoro-
  • 4-Amino-2-Fluorobenzoic Acid 2-Fluoro-4-Aminobenzoic Acid
  • 4-AMINO-2-FLUOROBENZOIC ACID USP/EP/BP
  • 446-31-1
  • Aromatic Amino Acids
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Fluorine series
  • Fluorin-contained Benzoic acid series
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Aromatic Amino Acids
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • intermediate